Zobrazeno 1 - 10
of 909
pro vyhledávání: '"Konrad Beyreuther"'
Autor:
Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model. Methods The Olink Target 96 Inflammation panel was as
Externí odkaz:
https://doaj.org/article/3313fd7b8403475fa5a95d2a1c0a25d6
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: Advances in biosciences have significantly expanded our knowledge and capabilities in medicine and technology. Genetic tests can now predict hereditary predisposition or susceptibility to diseases, while gene-editing tools like CRISPR/C
Externí odkaz:
https://doaj.org/article/04532148fc03458da9512a17838b7a6a
Autor:
Laura Perna, Hannah Stocker, Lena Burow, Léon Beyer, Kira Trares, Carolin Kurz, Selim Gürsel, Bernd Holleczek, Maia Tatò, Konrad Beyreuther, Ute Mons, Klaus Gerwert, Robert Perneczky, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clinic settings. The potential of combining SCC with genetic information and blood biomarkers of neurodegenerative di
Externí odkaz:
https://doaj.org/article/8ca4f10d01674786a34aa01b7d7f0079
Autor:
Ioanna A. Angelidou, Marina Makri, Konrad Beyreuther, Mercè Boada Rovira, Akyllina Despoti, Sebastiaan Engelborghs, Andrea Miguel, Isabel Rodríguez, Hannah Stocker, Joke Temmerman, Magda Tsolaki, Görsev Yener, Deniz Yerlikaya, Birgit Teichmann
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Pre-symptomatic screening is getting more attention in healthcare as it detects the risk for developing neurodegenerative diseases like Alzheimer’s disease (AD), which is very useful for treatment or prevention. AD screening could pla
Externí odkaz:
https://doaj.org/article/bdc506350d474f7c9e9d853204c36933
Autor:
Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-9 (2023)
Abstract Background In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to
Externí odkaz:
https://doaj.org/article/6bebce118115470eb721c902d18273b7
Autor:
Kira Trares, Megha Bhardwaj, Laura Perna, Hannah Stocker, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet. Methods The Olink Target
Externí odkaz:
https://doaj.org/article/a4badd12af52490da2fdd286cf7f6c8c
Autor:
Thi Ngoc Mai Nguyen, Li-Ju Chen, Kira Trares, Hannah Stocker, Bernd Holleczek, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background No population-based cohort study investigated a potential inverse association between long-term low-dose acetylsalicylic acid (ASA) use and all-cause dementia and its two most common sub-types Alzheimer’s disease (AD) and vascul
Externí odkaz:
https://doaj.org/article/7d0d0383274040969b3596322fa10685
Autor:
Leonid Yavich, Mari Oksman, Heikki Tanila, Petri Kerokoski, Mikko Hiltunen, Thomas van Groen, Jukka Puoliväli, Pekka T. Männistö, Arturo García-Horsman, Ewen MacDonald, Konrad Beyreuther, Tobias Hartmann, Pekka Jäkälä
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 303-313 (2005)
We have generated a transgenic mouse line overexpressing mutated human A30P α-synuclein under the control of the prion-related protein promoter. Immunohistology revealed mutated human A30P α-synuclein protein in numerous brain areas, but no gross m
Externí odkaz:
https://doaj.org/article/cfe6ff5d05a7497399ad277a7d3f402a
Autor:
Amee J George, R.M.Damian Holsinger, Catriona A McLean, Katrina M Laughton, Konrad Beyreuther, Genevieve Evin, Colin L Masters, Qiao-Xin Li
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 1, Pp 124-132 (2004)
Cholesterol is one of multiple factors, other than familial genetic mutations, that can influence amyloid-β peptide (Aβ) metabolism and accumulation in Alzheimer disease (AD). The effect of a high-cholesterol diet on amyloid precursor protein (APP)
Externí odkaz:
https://doaj.org/article/96e01e6ca6af429bbc91165eec660277
Autor:
Bart P.F Rutten, Oliver Wirths, Wilma D.J Van de Berg, Stefan F Lichtenthaler, Jochen Vehoff, Harry W.M Steinbusch, Hubert Korr, Konrad Beyreuther, Gerd Multhaup, Thomas A Bayer, Christoph Schmitz
Publikováno v:
Neurobiology of Disease, Vol 12, Iss 2, Pp 110-120 (2003)
Previous studies in the literature have resulted in conflicting reports on the potential neurotoxicity of the β-cleaved Alzheimer’s disease C-terminal fragment (β-CTF) of β-amyloid precursor protein in vivo. To readdress this question by rigorou
Externí odkaz:
https://doaj.org/article/ca01e9fa4854444c9a81e90af2847475