Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Konrad Aden"'
Autor:
Saskia Weber-Stiehl, Jan Taubenheim, Lea Järke, Christoph Röcken, Stefan Schreiber, Konrad Aden, Christoph Kaleta, Philip Rosenstiel, Felix Sommer
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Inflammation is characterized by a metabolic switch promoting glycolysis and lactate production. Hexokinases (HK) catalyze the first reaction of glycolysis and inhibition of epithelial HK2 protected from colitis in mice. HK2 expre
Externí odkaz:
https://doaj.org/article/4775c804c5424dc280a2419e833ba653
Autor:
Florian Tran, Alena Scharmacher, Nathan Baran, Neha Mishra, Marek Wozny, Samuel Pineda Chavez, Archana Bhardwaj, Sophia Hinz, Simonas Juzenas, Joana P. Bernardes, Laura Katharina Sievers, Matthias Lessing, Konrad Aden, Arne Lassen, Arne Bergfeld, Hauke Jann Weber, Lennart Neas, Stefania Vetrano, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect
Externí odkaz:
https://doaj.org/article/8d4d477204f94e37b6475a01df6352d4
Autor:
Danielle M.M. Harris, Silke Szymczak, Sven Schuchardt, Johannes Labrenz, Florian Tran, Lina Welz, Hanna Graßhoff, Henner Zirpel, Melike Sümbül, Mhmd Oumari, Nils Engelbogen, Ralf Junker, Claudio Conrad, Diamant Thaçi, Norbert Frey, Andre Franke, Stephan Weidinger, Bimba Hoyer, Philip Rosenstiel, Silvio Waschina, Stefan Schreiber, Konrad Aden
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105056- (2024)
Summary: Background: Chronic inflammatory diseases (CIDs) are systems disorders that affect diverse organs including the intestine, joints and skin. The essential amino acid tryptophan (Trp) can be broken down to various bioactive derivatives importa
Externí odkaz:
https://doaj.org/article/dec1a5c50cfb47d881f49ff39ebb0105
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chronic inflammatory diseases (CIDs), including inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge from an impaired complex network of inter- and intracellular biochemical interact
Externí odkaz:
https://doaj.org/article/8589f1d5f6624ef8a4bff349664b2a94
Autor:
Jian Lin, Zhanjun Lu, Gengfeng Li, Cui Zhang, Huiying Lu, Sheng Gao, Ruixin Zhu, Hailiang Huang, Konrad Aden, Jianhua Wang, Yingzi Cong, Huili Wu, Zhanju Liu
Publikováno v:
Journal of Innate Immunity, Pp 1-21 (2022)
Monocyte chemotactic protein-1-induced protein-1 (MCPIP-1) is highly expressed in activated immune cells and negatively regulates immune responses, while the mechanisms underlying the immunoregulation of neutrophils in acute bacterial infection and l
Externí odkaz:
https://doaj.org/article/ad666af5515a493e9fe9085cfab422a4
Autor:
Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease. Here the authors report that DNMT3A controls intestinal epithelial barrier function and r
Externí odkaz:
https://doaj.org/article/ddcd39941f044c5d889d3ab0cea581ef
Autor:
Neha Mishra, Konrad Aden, Johanna I. Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B. Sørensen, Silja H. Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A. Lyons, Joachim L. Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T. Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamic
Externí odkaz:
https://doaj.org/article/533221e6756c4c1d84dece9aba5649b6
Autor:
Jacqueline Moltzau Anderson, Simone Lipinski, Felix Sommer, Wei-Hung Pan, Olivier Boulard, Ateequr Rehman, Maren Falk-Paulsen, Stephanie T. Stengel, Konrad Aden, Robert Häsler, Richa Bharti, Sven Künzel, John F. Baines, Mathias Chamaillard, Philip Rosenstiel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 365-389 (2020)
Background & Aims: Loss-of-function variants in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) impair the recognition of the bacterial cell wall component muramyl-dipeptide and are associated with an increased risk for developi
Externí odkaz:
https://doaj.org/article/e95bfd75ec354ac7851ece1df85a26f4
Autor:
Jerko Štambuk, Frano Vučković, Siniša Habazin, Maja Hanić, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8473 (2022)
Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We a
Externí odkaz:
https://doaj.org/article/f7a9888be8ba40d5abdb3d81b287f535