Zobrazeno 1 - 10
of 180 670
pro vyhledávání: '"Konrad A"'
Autor:
Salmina J. Guivala, Konrad A. Bode, Jürgen G. Okun, Ece Kartal, Edzard Schwedhelm, Luca V. Pohl, Sarah Werner, Sandra Erbs, Holger Thiele, Petra Büttner
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality
Externí odkaz:
https://doaj.org/article/df99ae5302aa403c95b962f052eac7cd
Autor:
Florian Tran, Alena Scharmacher, Nathan Baran, Neha Mishra, Marek Wozny, Samuel Pineda Chavez, Archana Bhardwaj, Sophia Hinz, Simonas Juzenas, Joana P. Bernardes, Laura Katharina Sievers, Matthias Lessing, Konrad Aden, Arne Lassen, Arne Bergfeld, Hauke Jann Weber, Lennart Neas, Stefania Vetrano, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect
Externí odkaz:
https://doaj.org/article/8d4d477204f94e37b6475a01df6352d4
Autor:
Dorota Olender, Jacek Kujawski, Bartosz Skóra, Ewa Baranowska-Wójcik, Katarzyna Sowa-Kasprzak, Anna Pawełczyk, Lucjusz Zaprutko, Dominik Szwajgier, Konrad A. Szychowski
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37147- (2024)
In the area of research on neurodegenerative diseases, the current challenge is to search for appropriate research methods that would detect these diseases at the earliest possible stage, but also new active structures that would reduce the rate of t
Externí odkaz:
https://doaj.org/article/995f3b675c004e84a564ff285bc4a5f5
Autor:
Edyta Kaleniuk, Serhii Holota, Bartosz Skóra, Dmytro Khylyuk, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Applied Sciences, Vol 14, Iss 17, p 7692 (2024)
Presently, a major challenge is the search for new compounds that may exhibit an inhibitory effect on tumor progression. Recently, the 4-thiazolidinone (4-TZD) group has gained attention in this research field. The aim of the present study was to eva
Externí odkaz:
https://doaj.org/article/6df93435b7b948128ec84dbc5f1cd4db
Autor:
Danielle M.M. Harris, Silke Szymczak, Sven Schuchardt, Johannes Labrenz, Florian Tran, Lina Welz, Hanna Graßhoff, Henner Zirpel, Melike Sümbül, Mhmd Oumari, Nils Engelbogen, Ralf Junker, Claudio Conrad, Diamant Thaçi, Norbert Frey, Andre Franke, Stephan Weidinger, Bimba Hoyer, Philip Rosenstiel, Silvio Waschina, Stefan Schreiber, Konrad Aden
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105056- (2024)
Summary: Background: Chronic inflammatory diseases (CIDs) are systems disorders that affect diverse organs including the intestine, joints and skin. The essential amino acid tryptophan (Trp) can be broken down to various bioactive derivatives importa
Externí odkaz:
https://doaj.org/article/dec1a5c50cfb47d881f49ff39ebb0105
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Dominika Szlachcikowska, Anna Tabęcka-Łonczyńska, Serhii Holota, Olexandra Roman, Yulia Shepeta, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7329 (2024)
A range of hybrid molecules incorporating the ciminalum moiety in the thiazolidinone ring demonstrate significant anticancer and antimicrobial properties. Therefore, the aim of our study was to evaluate the properties and mechanism of action of two 4
Externí odkaz:
https://doaj.org/article/65c0530f214b49cba12dbb893211fada
Role of 4-Thiazolidinone–Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines
Autor:
Karolina Kosińska, Bartosz Skóra, Serhii Holota, Yulia Shepeta, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Cells, Vol 13, Iss 12, p 1007 (2024)
Cancer is one of the most important problems of modern societies. Recently, studies have reported the anticancer properties of rosiglitazone related to its ability to bind peroxisome proliferator receptor γ (PPARγ), which has various effects on can
Externí odkaz:
https://doaj.org/article/2888d91256ec4667861eaaf5050a1ada
Autor:
Tadeusz Pomianek, Martyna Zagórska-Dziok, Bartosz Skóra, Aleksandra Ziemlewska, Zofia Nizioł-Łukaszewska, Magdalena Wójciak, Ireneusz Sowa, Konrad A. Szychowski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5495 (2024)
Cornus mas L. is a rich source of vitamin C and polyphenols. Due to their health-benefit properties, C. mas L. extracts have been used in, e.g., dermatology and cosmetology, and as a food supplement. Peroxisome proliferator–activated receptor gamma
Externí odkaz:
https://doaj.org/article/22d2622127c641deac608595b60e49c9
Autor:
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chronic inflammatory diseases (CIDs), including inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge from an impaired complex network of inter- and intracellular biochemical interact
Externí odkaz:
https://doaj.org/article/8589f1d5f6624ef8a4bff349664b2a94