Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Konkal-Matt R Prasad"'
Autor:
R. John Lye, John M. Sanders, Brian H. Annex, Amina Saqib, Konkal Matt R. Prasad, Brent A. French, Arabindra B. Katwal
Publikováno v:
Journal of Vascular Surgery. 54:810-818
ObjectiveNeovascularization is a physiologic repair process that partly depends on nitric oxide. Extracellular superoxide dismutase (EcSOD) is the major scavenger of superoxide. It is an important regulator of nitric oxide bioavailability and thus pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d27694b173405484406e6c730973ec
https://doi.org/10.1016/j.jvs.2011.03.278
https://doi.org/10.1016/j.jvs.2011.03.278
Publikováno v:
The Journal of Gene Medicine. 13:333-341
Background Localized administration of a highly efficient gene delivery system in combination with a cardiac-selective promoter may provide an adequate biosafety profile in clinical applications such as coronary artery bypass graft surgery (CABG), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09125c14996a48a6a999297ff5a5048a
https://doi.org/10.1002/jgm.1576
https://doi.org/10.1002/jgm.1576
Publikováno v:
Gene therapy
Newly isolated serotypes of AAV readily cross the endothelial barrier to provide efficient transgene delivery throughout the body. However, tissue-specific expression is preferred in most experimental studies and gene therapy protocols. Previous effo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a009c6c9e058fa72d73c884f0a10f752
https://doi.org/10.1038/gt.2010.105
https://doi.org/10.1038/gt.2010.105
Autor:
Anca D. Dobrian, Konkal-Matt R Prasad, Jay K. Kolls, Emily Smith, Elena V. Galkina, Klaus Ley, Matthew J. Butcher
Publikováno v:
Circulation. 121:1746-1755
Background— T cells play an important role during the immune response that accompanies atherosclerosis. To date, the role for interleukin (IL)-17A in atherogenesis is not well defined. Here, we tested the hypothesis that atherosclerosis-prone condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b767c9317e827546e8c6fcb61976d4
https://doi.org/10.1161/circulationaha.109.924886
https://doi.org/10.1161/circulationaha.109.924886
Autor:
Zequan Yang, Marie Claire Toufektsian, Konkal Matt R. Prasad, Victor E. Laubach, Brent A. French, Yaqin Xu, Wesley D. Gilson, Frederick H. Epstein
Publikováno v:
Journal of the American College of Cardiology. 50(18):1799-1807
ObjectivesWe sought to determine the effect of inducible nitric oxide synthase (iNOS) expression on regional contractile function and left ventricular (LV) remodeling after reperfused myocardial infarction (MI).BackgroundInducible nitric oxide syntha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042cb1f6c13010f287bac28db3fcd9e1
Autor:
Lutgart Overbergh, Susan I. Ramos, Zequan Yang, Brent A. French, Joel Linden, Marie-Claire Toufektsian, Chantal Mathieu, Konkal Matt R. Prasad
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H1410-H1418
Following myocardial infarction (MI), contractile dysfunction develops not only in the infarct zone but also in noninfarcted regions of the left ventricle remote from the infarct zone. Inflammatory activation secondary to MI stimulates inducible nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72297bb0020ba25fbd7e8ecf053ab476
https://doi.org/10.1152/ajpheart.00860.2005
https://doi.org/10.1152/ajpheart.00860.2005
Publikováno v:
Biochemical and Biophysical Research Communications. 308:427-432
Leukocyte type 12-lipoxygenase (12-LO) is an enzyme specifically expressed in the beta cells of the pancreas. 12-LO oxidizes fatty acids such as arachidonic acid and linoleic acids to their respective hydroperoxides. Increased concentration of lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b630583ddb3bd6a11fd7434baea85f17
https://doi.org/10.1016/s0006-291x(03)01418-9
https://doi.org/10.1016/s0006-291x(03)01418-9
Publikováno v:
Circulation. 118
Introduction: The wide tissue tropism exhibited by AAV provides for efficient gene transfer throughout the body, but targeting gene expression to cardiomyocytes is desirable for cardiac gene therapy. We hypothesized that targeted overexpression of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ce1d0133e5aa12184ba12186ef9abc
https://doi.org/10.1161/circ.118.suppl_18.s_488-c
https://doi.org/10.1161/circ.118.suppl_18.s_488-c
Autor:
Yaqin Xu, Zequan Yang, Konkal-Matt R Prasad, Brent A. French, Stuart S. Berr, Marie-Claire Toufektsian
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 15(4)
Utility of adeno-associated virus 2 (AAV2) vectors for cardiac gene therapy is limited by the prolonged lag phase before maximal gene expression. Topoisomerase inhibition can induce AAV2-mediated gene expression in vivo, but with variable success in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5cd899e173781b1679e734eac2665c
https://pubmed.ncbi.nlm.nih.gov/17299410
https://pubmed.ncbi.nlm.nih.gov/17299410
Publikováno v:
Molecular Therapy. 13
AAV vectors transduce a wide range of tissues in-vivo and provide for long-term gene expression without provoking an immune response. Following intravenous (IV) injection, AAV serotypes 1 & 6 have been shown to provide for transgene expression throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635856e0bcde0d0c3c6c5fd718e6974d