Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Konjeti R. Sekhar"'
Autor:
Konjeti R. Sekhar, Simona G. Codreanu, Olivia C. Williams, Jeffrey C. Rathmell, W. Kimryn Rathmell, John A. McLean, Stacy D. Sherrod, Naira Baregamian
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionWe successfully developed a broad spectrum of patient-derived endocrine organoids (PDO) from benign and malignant neoplasms of thyroid, parathyroid, and adrenal glands. In this study, we employed functionally intact parathyroid PDOs from
Externí odkaz:
https://doaj.org/article/42c58611fb444e2e9c4d865f9c1364d3
Autor:
Konjeti R. Sekhar, David N. Hanna, Sriram Cyr, Jordan J. Baechle, Sudhakiranmayi Kuravi, Ramesh Balusu, Kimryn Rathmell, Naira Baregamian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with metastatic progression. Tumor progression can be influenced by metabolism, including antioxidant glutathione (GSH). Glutathione peroxidase 4 (GPX4) is
Externí odkaz:
https://doaj.org/article/ff50ed96be724bf381f35cd47bd0e4c3
Autor:
Amita R. Banga, Konjeti R. Sekhar, Kayla J. Rayford, Ashutosh Arun, Peace Odiase, Amar P. Garg, Maria F. Lima, Pius N. Nde, Fernando Villalta, Girish Rachakonda
Publikováno v:
Microbiology Research, Vol 13, Iss 4, Pp 721-739 (2022)
Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, has infected 6 million people, putting 70 million people at risk worldwide. Presently, very limited drugs are available, and these have severe side effects. Hence, there is an urgen
Externí odkaz:
https://doaj.org/article/c7ef648b155a4e2099e56b079b3b2c22
Autor:
Konjeti R. Sekhar, Michael L. Freeman
Publikováno v:
Cancer Research. 83:1573-1580
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid
Autor:
Naira Baregamian, Konjeti R. Sekhar, Evan S. Krystofiak, Maria Vinogradova, Giju Thomas, Emmanuel Mannoh, Carmen C. Solórzano, Colleen M. Kiernan, Anita Mahadevan-Jansen, Naji Abumrad, Michael L. Freeman, Vivian L. Weiss, Jeffrey C. Rathmell, W. Kimryn Rathmell
Publikováno v:
Surgery. 173:67-75
Recent advancements in 3-dimensional patient-derived organoid models have revolutionized the field of cancer biology. There is an urgent need for development of endocrine tumor organoid models for medullary thyroid carcinoma, adrenocortical carcinoma
Autor:
Michael L. Freeman, Konjeti R. Sekhar
Legends for Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a15a81e70092719eb1932ae667a067
https://doi.org/10.1158/0008-5472.22747006.v1
https://doi.org/10.1158/0008-5472.22747006.v1
Autor:
Michael L. Freeman, Konjeti R. Sekhar
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6e664802463a005ff1abe2ccd81490
https://doi.org/10.1158/0008-5472.c.6628636
https://doi.org/10.1158/0008-5472.c.6628636
Autor:
Michael L. Freeman, Konjeti R. Sekhar
The relationship between cancer cell line viability and NPM1 dependency, determined from genome-wide CRISPR-Cas9 screens (https://depmap.org/portal/interactive). A score of zero indicates that a gene is not essential. Common essential genes have a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ade5dd3aaad97fdbc8bbaea1a2daf95
https://doi.org/10.1158/0008-5472.22747003
https://doi.org/10.1158/0008-5472.22747003
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214670 (2019)
Radiation therapy is often combined with androgen deprivation therapy in the treatment of aggressive localized prostate cancer. However, castration-resistant disease may not respond to testosterone deprivation approaches. Enzalutamide is a second-gen
Externí odkaz:
https://doaj.org/article/c2a8a8b5fcbf4569a497866831a60e06
Autor:
Michael L. Freeman, Girish Rachakonda, Kenneth J. Salleng, Joseph L. Roti Roti, Robert P. Van Der Waal, Soumya Sasi, Ling Geng, William Hayes McDonald, Amudhan Venkateswaran, Peter A. Crooks, Penthala Narsimha Reddy, Yerramreddy Thirupathi Reddy, Konjeti R. Sekhar
PDF file - 46KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a62dc0fe6866209154512b1cff19b0
https://doi.org/10.1158/1078-0432.22443465.v1
https://doi.org/10.1158/1078-0432.22443465.v1