Multicenter Pharmacokinetic and Pharmacodynamic Study of Pembrolizumab for Non-small-Cell Lung Cancer in Patients Aged 75 Years and Older.

Autor: Yagishita S; Division of Molecular Pharmacology, National Cancer Center Research Institute, Tokyo, Japan., Yamanaka Y; Department of Thoracic Oncology, Kansai Medical University Hospital, Osaka, Japan., Kurata T; Department of Thoracic Oncology, Kansai Medical University Hospital, Osaka, Japan., Watanabe K; Department of Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Hosomi Y; Department of Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Horinouchi H; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan., Ohe Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan., Nakahara Y; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan., Naoki K; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan., Asao T; Department of Respiratory Medicine, Juntendo University Hospital, Tokyo, Japan., Takahashi K; Department of Respiratory Medicine, Juntendo University Hospital, Tokyo, Japan., Saeki S; Department of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan., Sakagami T; Department of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan., Nakashima K; Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan., Tsubata Y; Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan., Fujita Y; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Wakui H; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Furuta M; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Konishi JS; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Ohuchi M; Department of Pharmacology and Therapeutics, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan., Ando Y; Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan., Mizugaki H; Department of Respiratory Medicine, NHO Hokkaido Cancer Center, Sapporo, Japan., Hamada A; Division of Molecular Pharmacology, National Cancer Center Research Institute, Tokyo, Japan.; Department of Pharmacology and Therapeutics, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Oct; Vol. 116 (4), pp. 1042-1051. Date of Electronic Publication: 2024 Jun 17.