Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology.

Autor: Raiss CC; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., Braun TS; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., Konings IB; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., Grabmayr H; Lehrstuhl für Zellbiophysik E27, Technische Universität München, 85748 Garching, Germany., Hassink GC; Biomedical Signal and Systems, and Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands., Sidhu A; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., le Feber J; Biomedical Signal and Systems, and Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands., Bausch AR; Lehrstuhl für Zellbiophysik E27, Technische Universität München, 85748 Garching, Germany., Jansen C; Laboratorium Pathologie Oost-Nederland, Postbus 516, 7550 AM Hengelo, The Netherlands., Subramaniam V; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.; FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands., Claessens MM; Nanobiophysics Group, MESA+ Institute for Nanotechnology &MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2016 Mar 17; Vol. 6, pp. 23116. Date of Electronic Publication: 2016 Mar 17.

p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation.

Autor: Savelkoul PJ; Dept of Physiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., De Mattia F, Li Y, Kamsteeg EJ, Konings IB, van der Sluijs P, Deen PM

Publikováno v: Human mutation [Hum Mutat] 2009 Oct; Vol. 30 (10), pp. E891-903.

Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258.

Autor: Kamsteeg EJ; Department of Physiology, Radboud University Nijmegen Medical Center, Research Tower, 7th floor; UMC St Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands., Savelkoul PJ, Hendriks G, Konings IB, Nivillac NM, Lagendijk AK, van der Sluijs P, Deen PM

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2008 Mar; Vol. 455 (6), pp. 1041-54. Date of Electronic Publication: 2007 Oct 27.

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.

Autor: Kamsteeg EJ; Department of Physiology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands., Hendriks G, Boone M, Konings IB, Oorschot V, van der Sluijs P, Klumperman J, Deen PM

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Nov 28; Vol. 103 (48), pp. 18344-9. Date of Electronic Publication: 2006 Nov 13.

Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.

Autor: Detmers FJ; Department of Physiology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, Nijmegen, The Netherlands., de Groot BL, Müller EM, Hinton A, Konings IB, Sze M, Flitsch SL, Grubmüller H, Deen PM

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2006 May 19; Vol. 281 (20), pp. 14207-14. Date of Electronic Publication: 2006 Mar 21.