Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases

Autor: Babii, Oleg, Afonin, Sergii, Diel, Christian, Huhn, Marcel, Dommermuth, Jennifer, Schober, Tim, Koniev, S., Hrebonkin, Andrii, Nesterov-Mueller, Alexander, Komarov, I. V., Ulrich, Anne S.

Publikováno v: Angewandte Chemie-International Edition, 60 (40), 21789-21794

A bicyclic peptide scaffold was chemically adapted to generate diarylethene-based photoswitchable inhibitors of serine protease Bos taurus trypsin 1 (T1). Starting from a prototype molecule���sunflower trypsin inhibitor-1 (SFTI-1)���we ob

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Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases.

Autor: Babii O; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.; Institute of Microstructure Technology (IMT), KIT, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Afonin S; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany., Diel C; Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Huhn M; Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Dommermuth J; Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Schober T; Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.; Lumobiotics GmbH, Auer Straße 2, 76227, Karlsruhe, Germany., Koniev S; Taras Shevchenko National University of Kyiv, vul. Volodymyrska 60, 1601, Kyiv, Ukraine., Hrebonkin A; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany., Nesterov-Mueller A; Institute of Microstructure Technology (IMT), KIT, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Komarov IV; Taras Shevchenko National University of Kyiv, vul. Volodymyrska 60, 1601, Kyiv, Ukraine.; Lumobiotics GmbH, Auer Straße 2, 76227, Karlsruhe, Germany., Ulrich AS; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.; Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Sep 27; Vol. 60 (40), pp. 21789-21794. Date of Electronic Publication: 2021 Aug 25.