Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

Autor: Taro Shuin, Debra T. Silverman, Bin Zhu, Olusegun O. Onabajo, Candace D. Middlebrooks, Stephen J. Chanock, Montserrat Garcia-Closas, Stella Koutros, Núria Malats, Michiaki Kubo, A. Rouf Banday, Nathaniel Rothman, Jonine D. Figueroa, Krizia Ivana Udquim, Ashley Paquin, Manolis Kogevinas, Neal D. Freedman, Konichi Matsuda, Ludmila Prokunina-Olsson

Publikováno v: Middlebrooks, C D, Banday, A R, Matsuda, K, Udquim, K-I, Onabajo, O O, Paquin, A, Figueroa, J D, Zhu, B, Koutros, S, Kubo, M, Shuin, T, Freedman, N D, Kogevinas, M, Malats, N, Chanock, S J, Garcia-Closas, M, Silverman, D T, Rothman, N & Prokunina-Olsson, L 2016, ' Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors ', Nature Genetics, vol. 48, no. 11, pp. 1330–1338 . https://doi.org/10.1038/ng.3670

High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here we explored the contribution of two common germline variants in the APOBEC3 region. SNP rs1014971 was associa

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https://hdl.handle.net/20.500.11820/fa78b05e-e2f6-4109-8bc3-a0b3249c3aba