Zobrazeno 1 - 10
of 861
pro vyhledávání: '"Kongming Wu"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-48 (2024)
Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis fact
Externí odkaz:
https://doaj.org/article/a55d889783594e3f8f5e2cd5852e0f8f
Publikováno v:
Cancer Communications, Vol 44, Iss 7, Pp 739-760 (2024)
Abstract Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed cancer treatment. Despite its success, many patients struggle to respond adequately or sustain long‐lasting clinical improvement. A growing consen
Externí odkaz:
https://doaj.org/article/85912ae7e92543419e0557cbeeca5c02
Publikováno v:
Journal of Integrative Agriculture, Vol 23, Iss 4, Pp 1300-1314 (2024)
The invasive fall armyworm Spodoptera frugiperda (J. E. Smith) invaded Asia in 2018, colonizing the tropical and southern subtropical regions as well as migrating with the monsoons into Northeast Asia during spring and summer. This has resulted in wi
Externí odkaz:
https://doaj.org/article/682ee1c4f65641068656e552df702ed2
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells can result in T cell exhaustion
Externí odkaz:
https://doaj.org/article/c9b496fd3bf840cc94a348cdb1a67900
Autor:
Zhenxing Liu, Chongyu Liao, Luming Zou, Minghui Jin, Yinxue Shan, Yudong Quan, Hui Yao, Lei Zhang, Peng Wang, Zhuangzhuang Liu, Na Wang, Anjing Li, Kaiyu Liu, Bruce E Tabashnik, David G Heckel, Kongming Wu, Yutao Xiao
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002704 (2024)
The vegetative insecticidal protein Vip3Aa from Bacillus thuringiensis (Bt) has been produced by transgenic crops to counter pest resistance to the widely used crystalline (Cry) insecticidal proteins from Bt. To proactively manage pest resistance, th
Externí odkaz:
https://doaj.org/article/f0572803887240199d018559e2f13b74
Autor:
Ximin Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang, Zaiqi Wang, Qi Mei, Chuang Chen, Kongming Wu
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with crizotinib has shown
Externí odkaz:
https://doaj.org/article/24d48c60eaca471d9e58400153b83d6a
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting as antibacterial c
Externí odkaz:
https://doaj.org/article/5f7eb95826cc47ed9db134cb2c9a90be
Autor:
Mengshi Luo, Wenjian Gong, Yuewen Zhang, Huayi Li, Ding Ma, Kongming Wu, Qinglei Gao, Yong Fang
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-23 (2023)
Abstract T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relies on the pool of functional T ce
Externí odkaz:
https://doaj.org/article/e06ce864c10748189c45e05e52da659d
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-55 (2023)
Abstract Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune c
Externí odkaz:
https://doaj.org/article/2511b2e1dbb841e1a6a4f281545a4c1e
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2023)
Abstract Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulates cancer stem cell activities an
Externí odkaz:
https://doaj.org/article/a7c6a95e71c549fd82bd61aa71806f0c