Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Kong Peng Lam"'
Autor:
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTT-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages
Externí odkaz:
https://doaj.org/article/8d90c44d609a46ee84e4e146feab623d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The dysregulation of the biochemical pathways in cancer promotes oncogenic transformations and metastatic potential. Recent studies have shed light on how obesity and altered lipid metabolism could be the driving force for tumor progression. Here, in
Externí odkaz:
https://doaj.org/article/589a1fb5340e446995d4078d22039754
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8092 (2023)
Mesenchymal stem/stromal cell small extracellular vesicles (MSC−sEVs) have shown promise in treating a wide range of animal models of various human diseases, which has led to their consideration for clinical translation. However, the possibility of
Externí odkaz:
https://doaj.org/article/d244a347efc14d4d919019eeae600e30
Autor:
Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1057 (2022)
The advent of the Omicron variant globally has hastened the requirement for a booster vaccination dose to confer continuous protection against symptomatic SARS-CoV2 infection. However, different vaccines are available in different countries, and indi
Externí odkaz:
https://doaj.org/article/7087cf598dbe4cd4bef79e323bea4c18
Autor:
Shi Yong Neo, Mariana M. S. Oliveira, Le Tong, Yi Chen, Ziqing Chen, Sonia Cismas, Nutsa Burduli, Anna Malmerfelt, Joey Kay Hui Teo, Kong-Peng Lam, Evren Alici, Leonard Girnita, Arnika K. Wagner, Lisa S. Westerberg, Andreas Lundqvist
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background Inflammation in the eye is often associated with aggravated ocular diseases such as uveal melanoma (UM). Poor prognosis of UM is generally associated with high potential of metastatic liver dissemination. A strong driver of metast
Externí odkaz:
https://doaj.org/article/fe86612e7417488c88ce9200a4e0f4ec
Autor:
Say Kong Ng, Tessa Rui Min Tan, Yang Wang, Daniel Ng, Lin-Tang Goh, Muriel Bardor, Victor Vai Tak Wong, Kong Peng Lam
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52785 (2012)
Dectin-1 (CLEC7A) is a C-type lectin receptor that binds to β-glucans found in fungal cell walls to act as a major pattern recognition receptor (PRR). Since β-glucans epitope is not present in human cells, we are of the opinion that Dectin-1 can ha
Externí odkaz:
https://doaj.org/article/9a6db7d4973f4f33a9bef705f57e9b5e
Autor:
Kong-Peng Lam, Shiyong Neo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a8fc1e01c6fd492682afdf0d11831232
Autor:
Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo, Hsueh Lee Lim, Susana Soo-Yeon Kim, Andy Hee-Meng Tan, Kong-Peng Lam
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved
Externí odkaz:
https://doaj.org/article/9e614d935ff7407392251563afe5b819
Autor:
Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak, Liwei Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
Externí odkaz:
https://doaj.org/article/232a7455244b4ab7a369fc9f8653e33a
Autor:
Gui-Xin Ruan, Yuxing Li, Wenjing Chen, Hengjun Huang, Rui Zhang, Changxu Chen, Kong-Peng Lam, Shengli Xu, Xijun Ou
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110338- (2022)
Summary: The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and tumorigenesis. However, the physiological
Externí odkaz:
https://doaj.org/article/37745cba1d4f4c669ce1e89dd3a6fc14