Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Kong Peng Lam"'
Autor:
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTT-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages
Externí odkaz:
https://doaj.org/article/8d90c44d609a46ee84e4e146feab623d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The dysregulation of the biochemical pathways in cancer promotes oncogenic transformations and metastatic potential. Recent studies have shed light on how obesity and altered lipid metabolism could be the driving force for tumor progression. Here, in
Externí odkaz:
https://doaj.org/article/589a1fb5340e446995d4078d22039754
Autor:
Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1057 (2022)
The advent of the Omicron variant globally has hastened the requirement for a booster vaccination dose to confer continuous protection against symptomatic SARS-CoV2 infection. However, different vaccines are available in different countries, and indi
Externí odkaz:
https://doaj.org/article/7087cf598dbe4cd4bef79e323bea4c18
Autor:
Say Kong Ng, Tessa Rui Min Tan, Yang Wang, Daniel Ng, Lin-Tang Goh, Muriel Bardor, Victor Vai Tak Wong, Kong Peng Lam
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52785 (2012)
Dectin-1 (CLEC7A) is a C-type lectin receptor that binds to β-glucans found in fungal cell walls to act as a major pattern recognition receptor (PRR). Since β-glucans epitope is not present in human cells, we are of the opinion that Dectin-1 can ha
Externí odkaz:
https://doaj.org/article/9a6db7d4973f4f33a9bef705f57e9b5e
Autor:
Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo, Hsueh Lee Lim, Susana Soo-Yeon Kim, Andy Hee-Meng Tan, Kong-Peng Lam
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved
Externí odkaz:
https://doaj.org/article/9e614d935ff7407392251563afe5b819
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-15 (2021)
Abstract Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although B
Externí odkaz:
https://doaj.org/article/9bdc3c983c534270a4bd25ff43292385
Autor:
Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak, Liwei Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
Externí odkaz:
https://doaj.org/article/232a7455244b4ab7a369fc9f8653e33a
Autor:
Gui-Xin Ruan, Yuxing Li, Wenjing Chen, Hengjun Huang, Rui Zhang, Changxu Chen, Kong-Peng Lam, Shengli Xu, Xijun Ou
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110338- (2022)
Summary: The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and tumorigenesis. However, the physiological
Externí odkaz:
https://doaj.org/article/37745cba1d4f4c669ce1e89dd3a6fc14
Autor:
Liting Hang, Ziyin Wang, Aaron S.C. Foo, Geraldine W.Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Publikováno v:
Neurobiology of Disease, Vol 161, Iss , Pp 105560- (2021)
Emerging studies implicate energy dysregulation as an underlying trigger for Parkinson's disease (PD), suggesting that a better understanding of the molecular pathways governing energy homeostasis could help elucidate therapeutic targets for the dise
Externí odkaz:
https://doaj.org/article/e681f29124b6458790dfeedd53c81d8a
Autor:
Zixi Wang, Di Guan, Jianxin Huo, Subhra K. Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu, Kong-Peng Lam
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support
Externí odkaz:
https://doaj.org/article/f9f6d1be24ff46a7acb99d102b7e248c