The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.

Autor: Wright, Amanda L.^1,2 (AUTHOR), Konen, Lyndsey M.³ (AUTHOR), Mockett, Bruce G.⁴ (AUTHOR), Morris, Gary P.^3,5 (AUTHOR), Singh, Anurag⁴ (AUTHOR), Burbano, Lisseth Estefania^6,7 (AUTHOR), Milham, Luke^1,3 (AUTHOR), Hoang, Monica⁸ (AUTHOR), Zinn, Raphael³ (AUTHOR), Chesworth, Rose⁹ (AUTHOR), Tan, Richard P.^10,11 (AUTHOR), Royle, Gordon A.^12,13 (AUTHOR), Clark, Ian¹⁴ (AUTHOR), Petrou, Steven^6,7 (AUTHOR), Abraham, Wickliffe C.⁴ (AUTHOR), Vissel, Bryce^1,3 (AUTHOR) Bryce.Vissel@gmail.com

Publikováno v: Molecular Neurodegeneration. 9/28/2023, p1-25. 25p.

A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.

Autor: Konen, Lyndsey M.^1,2, L.Wright, Amanda³, Royle, Gordon A.^4,5, Morris, Gary P.^1,2, Lau, Benjamin K.⁶, Seow, Patrick W.⁶, Zinn, Raphael^1,2, Milham, Luke T.^1,2, Vaughan, Christopher W.⁶, Visse, Bryce^1,2 bryce.vissel@uts.edu.au

Publikováno v: Molecular Brain. 2/27/2020, Vol. 13, p1-19. 19p.

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