Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.

Autor: Xie Y; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Kril LM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Yu T; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Zhang W; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Frasinyuk MS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine., Bondarenko SP; National University of Food Technologies, Kyiv, 01601, Ukraine., Kondratyuk KM; Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine., Hausman E; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Martin ZM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Wyrebek PP; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Liu X; Center for Drug Innovation and Discovery, Hebei Normal University, Shijiazhuang, Hebei, 050024, People's Republic of China., Deaciuc A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Dwoskin LP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Chen J; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Zhu H; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Zhan CG; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Molecular Modeling and Pharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Sviripa VM; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Blackburn J; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA. dwatt@uky.edu.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA. dwatt@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA. dwatt@uky.edu.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA. dwatt@uky.edu., Liu C; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA. chunming.liu@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA. chunming.liu@uky.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Apr 23; Vol. 9 (1), pp. 6439. Date of Electronic Publication: 2019 Apr 23.

Semisynthetic aurones A14 protects against T-cell acute lymphoblastic leukemia via suppressing proliferation and inducing cell cycle arrest with apoptosis.

Autor: Wang, Meng¹ (AUTHOR), Li, Lisi¹ (AUTHOR), Fan, Tengyun¹ (AUTHOR), Cao, Lixue¹ (AUTHOR), Zhang, Jiayi¹ (AUTHOR), Li, Shuang¹ (AUTHOR), Liu, Chunming² (AUTHOR), Liu, Xifu^1,3 (AUTHOR) xfliu@hebtu.edu.cn

Publikováno v: Chinese Medicine. 12/12/2022, Vol. 17 Issue 1, p1-13. 13p.

Synthesis and in vitro anticytomegalovirus activity of 5-hydroxyalkylamino-1,3-oxazoles derivatives.

Autor: Abdurakhmanova, Esma R., Brusnakov, Mykhailo Y., Golovchenko, Oleksandr V., Pilyo, Stepan G., Velychko, Nataliya V., Harden, Emma A., Prichard, Mark N., James, Scott H., Zhirnov, Victor V., Brovarets, Volodymyr S.

Publikováno v: Medicinal Chemistry Research; Sep2020, Vol. 29 Issue 9, p1669-1675, 7p

Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde.

Autor: Sokolyuk, Pavlo, Kondratov, Ivan, Gavrylenko, Olexiy, Tolmachov, Andrey

Publikováno v: Molecular Diversity; Feb2016, Vol. 20 Issue 1, p1-7, 7p

S-Heterocycles : Synthesis and Biological Evaluation

Autor: Keshav Lalit Ameta

This book presents the recent research on sulfur-containing heterocyclic scaffolds that are crucial for biological processes. The numerous synthetic techniques utilized for the design and synthesis of different sized S-heterocycles, particularly biol