Genome editing with DNA-dependent polymerases.

Autor: Cowan QT; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA., Komor AC; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA. akomor@ucsd.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23.

Functional EPAS1 / HIF2A missense variant is associated with hematocrit in Andean highlanders.

Autor: Lawrence ES; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Gu W; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Bohlender RJ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Anza-Ramirez C; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Cole AM; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Yu JJ; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Hu H; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heinrich EC; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, USA., O'Brien KA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK., Vasquez CA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Cowan QT; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Bruck PT; Department of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA., Mercader K; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA., Alotaibi M; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA., Long T; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Sapient Bioanalytics, LLC, San Diego, CA, USA., Hall JE; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Moya EA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Bauk MA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Reeves JJ; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Kong MC; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Salem RM; Herbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, USA., Vizcardo-Galindo G; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Macarlupu JL; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Figueroa-Mujíca R; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Bermudez D; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Corante N; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Gaio E; Laboratório de Fisiologia Respiratória, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil., Fox KP; Department of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Havulinna AS; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM-HiLIFE), Helsinki, Finland., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK., Malhotra A; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Powel FL; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Jain M; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Sapient Bioanalytics, LLC, San Diego, CA, USA., Komor AC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Cavalleri GL; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Huff CD; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Villafuerte FC; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Simonson TS; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: Science advances [Sci Adv] 2024 Feb 09; Vol. 10 (6), pp. eadj5661. Date of Electronic Publication: 2024 Feb 09.

Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies.

Autor: Medina-Munoz HC; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Kofman E; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA., Jagannatha P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA., Boyle EA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Yu T; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Jones KL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Mueller JR; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Lykins GD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Doudna AT; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Park SS; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Blue SM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Ranzau BL; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA., Kohli RM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Komor AC; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 25. Date of Electronic Publication: 2023 Sep 25.

The Design and Application of DNA-Editing Enzymes as Base Editors.

Autor: Rallapalli KL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA; email: akomor@ucsd.edu., Komor AC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA; email: akomor@ucsd.edu.

Publikováno v: Annual review of biochemistry [Annu Rev Biochem] 2023 Jun 20; Vol. 92, pp. 43-79. Date of Electronic Publication: 2023 Apr 05.

In the business of base editors: Evolution from bench to bedside.

Autor: Porto EM; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America., Komor AC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2023 Apr 12; Vol. 21 (4), pp. e3002071. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).