A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism.

Autor: Eirini D Tseligka, Komla Sobo, Luc Stoppini, Valeria Cagno, Fabien Abdul, Isabelle Piuz, Pascal Meylan, Song Huang, Samuel Constant, Caroline Tapparel

Publikováno v: PLoS Pathogens, Vol 14, Iss 8, p e1007190 (2018)

Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild and self-limited illness that is sometimes associated with severe neurological complications. EV71 neurotropic determinants remain ill-defined to date. We previously identified a mutat

Externí odkaz: https://doaj.org/article/d3a94119372c425b963f397ae686ccaa

Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking.

Autor: Komla Sobo, Isabelle Le Blanc, Pierre-Philippe Luyet, Marc Fivaz, Charles Ferguson, Robert G Parton, Jean Gruenberg, F Gisou van der Goot

Publikováno v: PLoS ONE, Vol 2, Iss 9, p e851 (2007)

BackgroundPathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A,

Externí odkaz: https://doaj.org/article/43679b340211428a86b4042b963ebf6f

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

Autor: Luc Stoppini, Eirini Tseligka, Fabien Abdul, Komla Sobo, Caroline Tapparel, Isabelle Piuz, Samuel Constant, Pascal Meylan, Valeria Cagno, Song Huang

Publikováno v: PLoS pathogens, vol. 14, no. 8, pp. e1007190
PLoS Pathogens
PLOS Pathogens, Vol. 14, No 8 (2018) P. e1007190
PLoS Pathogens, Vol 14, Iss 8, p e1007190 (2018)

Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild and self-limited illness that is sometimes associated with severe neurological complications. EV71 neurotropic determinants remain ill-defined to date. We previously identified a mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684a2c4f021184dea4b117654c92789b
https://serval.unil.ch/resource/serval:BIB_AA8B59925F70.P001/REF.pdf

Echovirus 11 infection induces dramatic changes in the actin cytoskeleton of polarized Caco-2 cells

Autor: Thomas Alexander Mckee, Amanda D. Stuart, Laura Rubbia-Brandt, Komla Sobo, T. David K. Brown

Publikováno v: The Journal of general virology
Journal of General Virology, Vol. 93, No Pt 3 (2012) pp. 475-87

Binding of echovirus 11 strain 207 (EV11-207) to Caco-2 monolayers results in rapid transfer of the virus to tight junctions prior to uptake. Using a confocal microscopy based-method, this study quantified the spatiotemporal distribution of actin dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b923cc4aa5a4701ec5d66ee85eba128

Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

Autor: Sylvie Kieffer-Jaquinod, Komla Sobo, Céline Lafourcade, Jérôme Garin, F. Gisou van der Goot

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 7, p e2758 (2008)

The lumen of endosomal organelles becomes increasingly acidic when going from the cell surface to lysosomes. Luminal pH thereby regulates important processes such as the release of internalized ligands from their receptor or the activation of lysosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c92bed030fb828c80afd725c4ebbce
https://pubmed.ncbi.nlm.nih.gov/18648502