Chronic treatment with the MEK inhibitor PD-0325901 reverses enhanced I-O relationships of excitatory field potentials in Syngap1+/− mice

Autor: Kopanitsa, M, Gou, G, Afinowi, N, Bayés, À, Grant, SGN, Komiyama, NH

Background: Synaptic Ras-GTPase-activating protein 1 (SYNGAP1) is an abundant brain-specific protein localized at the postsynaptic density of mammalian excitatory synapses. SYNGAP1 functions as a crucial regulator of downstream intracellular signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::cb8b0ee4b31e544430657487ba4770ca
http://hdl.handle.net/10044/1/58584

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

Autor: Frank, RAW, Zhu, F, Komiyama, NH, Grant, SGN

PSD95 is an abundant postsynaptic scaffold protein in glutamatergic synapses that assembles into supercomplexes composed of over 80 proteins including neurotransmitter receptors, ion channels and adhesion proteins. How these diverse constituents are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e7d2aba5670fe95e6d2ce1a7ce783be6
https://eprints.whiterose.ac.uk/135851/1/Frank_et_al-2017-Journal_of_Neurochemistry.pdf

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.

Autor: Hagihara H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Shoji H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Hattori S; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Sala G; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Takamiya Y; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tanaka M; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Ihara M; Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan., Shibutani M; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan., Hatada I; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan., Hori K; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Hoshino M; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Nakao A; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan., Mori Y; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan., Okabe S; Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Matsushita M; Department of Molecular Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan., Urbach A; Department of Neurology, Jena University Hospital, Jena, Germany., Katayama Y; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Matsumoto A; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Katori S; Laboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan., Sato T; Laboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan., Iwasato T; Laboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan., Nakamura H; Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Goshima Y; Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Raveau M; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan., Tatsukawa T; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan., Yamakawa K; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan.; Department of Neurodevelopmental Disorder Genetics, Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Takahashi N; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Physiology, Kitasato University School of Medicine, Sagamihara, Japan., Kasai H; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan., Inazawa J; Research Core, Tokyo Medical and Dental University, Tokyo, Japan., Nobuhisa I; Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Kagawa T; Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Taga T; Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Darwish M; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Behavioral Physiology, Graduate School of Innovative Life Science, University of Toyama, Toyama, Japan., Nishizono H; Medical Research Institute, Kanazawa Medical University, Kahoku, Japan., Takao K; Department of Behavioral Physiology, Graduate School of Innovative Life Science, University of Toyama, Toyama, Japan.; Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan., Sapkota K; Department of Neuroscience, Southern Research, Birmingham, United States., Nakazawa K; Department of Neuroscience, Southern Research, Birmingham, United States., Takagi T; Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan., Fujisawa H; Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University, Toyoake, Japan., Sugimura Y; Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University, Toyoake, Japan., Yamanishi K; Department of Neuropsychiatry, Hyogo Medical University School of Medicine, Nishinomiya, Japan., Rajagopal L; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States., Hannah ND; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States., Meltzer HY; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States., Yamamoto T; Department of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Wakatsuki S; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Araki T; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Tabuchi K; Department of Molecular & Cellular Physiology, Shinshu University School of Medicine, Matsumoto, Japan., Numakawa T; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Kunugi H; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan., Huang FL; Program of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States., Hayata-Takano A; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.; Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan., Hashimoto H; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan.; Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Japan.; Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Suita, Japan., Tamada K; RIKEN Brain Science Institute, Wako, Japan.; Department of Physiology and Cell Biology, Kobe University School of Medicine, Kobe, Japan., Takumi T; RIKEN Brain Science Institute, Wako, Japan.; Department of Physiology and Cell Biology, Kobe University School of Medicine, Kobe, Japan., Kasahara T; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako, Japan.; Institute of Biology and Environmental Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany., Kato T; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako, Japan.; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan., Graef IA; Department of Pathology, Stanford University School of Medicine, Stanford, United States., Crabtree GR; Department of Pathology, Stanford University School of Medicine, Stanford, United States., Asaoka N; Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Hatakama H; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Kaneko S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Kohno T; Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan., Hattori M; Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan., Hoshiba Y; Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan., Miyake R; Laboratory for Multi-scale Biological Psychiatry, RIKEN Center for Brain Science, Wako, Japan., Obi-Nagata K; Laboratory for Multi-scale Biological Psychiatry, RIKEN Center for Brain Science, Wako, Japan., Hayashi-Takagi A; Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.; Laboratory for Multi-scale Biological Psychiatry, RIKEN Center for Brain Science, Wako, Japan., Becker LJ; Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France., Yalcin I; Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France., Hagino Y; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Kotajima-Murakami H; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Moriya Y; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Ikeda K; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Kim H; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, United States., Kaang BK; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Otabi H; College of Agriculture, Ibaraki University, Ami, Japan.; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan., Yoshida Y; College of Agriculture, Ibaraki University, Ami, Japan., Toyoda A; College of Agriculture, Ibaraki University, Ami, Japan.; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan.; Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ibaraki, Japan., Komiyama NH; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom., Grant SGN; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom., Ida-Eto M; Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, Tsu, Japan., Narita M; Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, Tsu, Japan., Matsumoto KI; Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Japan., Okuda-Ashitaka E; Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan., Ohmori I; Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Shimada T; Child Brain Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Yamagata K; Child Brain Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Ageta H; Division for Therapies Against Intractable Diseases, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tsuchida K; Division for Therapies Against Intractable Diseases, Center for Medical Science, Fujita Health University, Toyoake, Japan., Inokuchi K; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.; Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.; Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST), University of Toyama, Toyama, Japan., Sassa T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan., Kihara A; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan., Fukasawa M; Department of Anatomy II, Fujita Health University School of Medicine, Toyoake, Japan., Usuda N; Department of Anatomy II, Fujita Health University School of Medicine, Toyoake, Japan., Katano T; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan., Tanaka T; Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Yoshihara Y; Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Wako, Japan., Igarashi M; Department of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.; Transdiciplinary Research Program, Niigata University, Niigata, Japan., Hayashi T; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan., Ishikawa K; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.; Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan., Yamamoto S; Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa, Japan., Nishimura N; Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa, Japan., Nakada K; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.; Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan., Hirotsune S; Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan., Egawa K; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Higashisaka K; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan., Tsutsumi Y; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan., Nishihara S; Glycan & Life Systems Integration Center (GaLSIC), Soka University, Tokyo, Japan., Sugo N; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan., Yagi T; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan., Ueno N; Laboratory of Morphogenesis, National Institute for Basic Biology, Okazaki, Japan., Yamamoto T; Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Japan., Kubo Y; Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Japan., Ohashi R; Laboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki, Japan.; Department of Basic Biology, SOKENDAI (Graduate University for Advanced Studies), Okazaki, Japan.; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan., Shiina N; Laboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki, Japan.; Department of Basic Biology, SOKENDAI (Graduate University for Advanced Studies), Okazaki, Japan.; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan., Shimizu K; Department of Biological Sciences, School of Science, The University of Tokyo, Tokyo, Japan., Higo-Yamamoto S; Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan., Oishi K; Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.; School of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, Japan., Mori H; Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan., Furuse T; Mouse Phenotype Analysis Division, Japan Mouse Clinic, RIKEN BioResource Research Center (BRC), Tsukuba, Japan., Tamura M; Mouse Phenotype Analysis Division, Japan Mouse Clinic, RIKEN BioResource Research Center (BRC), Tsukuba, Japan., Shirakawa H; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Sato DX; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.; Graduate School of Life Sciences, Tohoku University, Sendai, Japan., Inoue YU; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Inoue T; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Komine Y; Young Researcher Support Group, Research Enhancement Strategy Office, National Institute for Basic Biology, National Institute of Natural Sciences, Okazaki, Japan.; Division of Brain Biology, National Institute for Basic Biology, Okazaki, Japan., Yamamori T; Division of Brain Biology, National Institute for Basic Biology, Okazaki, Japan.; Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science, Wako, Japan., Sakimura K; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan., Miyakawa T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.

Publikováno v: ELife [Elife] 2024 Mar 26; Vol. 12. Date of Electronic Publication: 2024 Mar 26.

A brain atlas of synapse protein lifetime across the mouse lifespan.

Autor: Bulovaite E; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Qiu Z; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Kratschke M; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Zgraj A; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Fricker DG; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Tuck EJ; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Gokhale R; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK., Koniaris B; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; School of Computing, Edinburgh Napier University, Edinburgh EH10 5DT, UK., Jami SA; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA., Merino-Serrais P; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, UPM, 28223 Madrid, Spain; Instituto Cajal, CSIC, 28002 Madrid, Spain., Husi E; Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Mendive-Tapia L; Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK., Vendrell M; Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK., O'Dell TJ; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA., DeFelipe J; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, UPM, 28223 Madrid, Spain; Instituto Cajal, CSIC, 28002 Madrid, Spain., Komiyama NH; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK; The Patrick Wild Centre for Research into Autism, Fragile X Syndrome & Intellectual Disabilities, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK; Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh EH8 9XD, UK., Holtmaat A; Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Fransén E; Department of Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 10044 Stockholm, Sweden; Science for Life Laboratory, KTH Royal Institute of Technology, 171 65 Solna, Sweden., Grant SGN; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address: seth.grant@ed.ac.uk.

Publikováno v: Neuron [Neuron] 2022 Dec 21; Vol. 110 (24), pp. 4057-4073.e8. Date of Electronic Publication: 2022 Oct 05.

Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis.

Autor: Broadhead MJ; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.; Edinburgh Super-Resolution Imaging Consortium, Heriot Watt University, Edinburgh, UK., Bonthron C; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK., Waddington J; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK., Smith WV; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK., Lopez MF; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK., Burley S; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK., Valli J; Edinburgh Super-Resolution Imaging Consortium, Heriot Watt University, Edinburgh, UK., Zhu F; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK., Komiyama NH; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Smith C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, The University of Edinburgh, Edinburgh, UK., Grant SGN; Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Miles GB; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK. gbm4@st-andrews.ac.uk.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2022 Apr; Vol. 143 (4), pp. 471-486. Date of Electronic Publication: 2022 Mar 19.