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Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.

Autor: Hulme H; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Meikle LM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Strittmatter N; Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., van der Hooft JJJ; Bioinformatics Group, Wageningen University, Wageningen 6708 PB, Netherlands., Swales J; Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Bragg RA; Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, UK., Villar VH; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Ormsby MJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Barnes S; Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, and The Patrick Wild Centre, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK., Brown SL; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9NT, UK., Dexter A; National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK., Kamat MT; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Komen JC; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Walker D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Milling S; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Osterweil EK; Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, and The Patrick Wild Centre, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK., MacDonald AS; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9NT, UK., Schofield CJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Tardito S; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Bunch J; National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK.; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK., Douce G; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Edgar JM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.; Department of Neurogenetics, Max Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Goettingen, Germany., Edrada-Ebel R; Natural Products Metabolomics Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK., Goodwin RJA; Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Burchmore R; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Wall DM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

Publikováno v: Science advances [Sci Adv] 2020 Mar 11; Vol. 6 (11), pp. eaax6328. Date of Electronic Publication: 2020 Mar 11 (Print Publication: 2020).

Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse.

Autor: Bird MJ; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia., Wijeyeratne XW; ‡Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Komen JC; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia., Laskowski A; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia., Ryan MT; ‡Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Thorburn DR; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia., Frazier AE; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia.

Publikováno v: Bioscience reports [Biosci Rep] 2014 Nov 21; Vol. 34 (6), pp. e00151. Date of Electronic Publication: 2014 Nov 21.

Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.

Autor: Leong DW; Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia., Komen JC, Hewitt CA, Arnaud E, McKenzie M, Phipson B, Bahlo M, Laskowski A, Kinkel SA, Davey GM, Heath WR, Voss AK, Zahedi RP, Pitt JJ, Chrast R, Sickmann A, Ryan MT, Smyth GK, Thorburn DR, Scott HS

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2012 Jun 08; Vol. 287 (24), pp. 20652-63. Date of Electronic Publication: 2012 Apr 25.

Ataxia with loss of Purkinje cells in a mouse model for Refsum disease.

Autor: Ferdinandusse S; Academic Medical Center, Department of Clinical Chemistry (Laboratory of Genetic Metabolic Diseases), Emma's Children Hospital, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. s.ferdinandusse@amc.uva.nl, Zomer AW, Komen JC, van den Brink CE, Thanos M, Hamers FP, Wanders RJ, van der Saag PT, Poll-The BT, Brites P

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Nov 18; Vol. 105 (46), pp. 17712-7. Date of Electronic Publication: 2008 Nov 11.