Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Komath Damodaran"'
Autor:
Betty K. Samulitis, Terry H. Landowski, Haiyong Han, Robert T. Dorr, Daniel D. Von Hoff, Suzu Igarashi, Lee Wisner, Komath Damodaran, Yu Zhao, Paul Beroza
Publikováno v:
Investigational New Drugs. 31:576-586
Deletions or mutations in the tumor suppressor gene DPC4 (deleted in pancreatic carcinoma locus 4) are common in colon and pancreatic cancers. Using the Target-related Affinity Profiling (TRAP) chemical library screening method, a novel agent, UA8967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c79e4c8977603b8aeebf799a055b209
https://doi.org/10.1007/s10637-012-9901-z
https://doi.org/10.1007/s10637-012-9901-z
Autor:
Carol C. Edwards, Philip M. Potter, Paul P. Beroza, Christopher L. Morton, Xin Wei, Kyoung Jin P. Yoon, Randy M. Wadkins, Komath Damodaran, Janice L. Hyatt, and Mary K. Danks, John C. Obenauer, Monika Wierdl
Publikováno v:
Journal of Medicinal Chemistry. 48:2906-2915
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of selective inhibitors of these proteins has proved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77db80b3a39483e27d1065236f33f53
https://doi.org/10.1021/jm049011j
https://doi.org/10.1021/jm049011j
Publikováno v:
Journal of medicinal chemistry. 54(15)
The metabolism of poly(ADP-ribose) (PAR) in response to DNA strand breaks, which involves the concerted activities of poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolase (PARG), modulates cell recovery or cell death depending upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288607482a15e615a6a6df95bc64c3ec
https://pubmed.ncbi.nlm.nih.gov/21692479
https://pubmed.ncbi.nlm.nih.gov/21692479
Autor:
Reyna J. Simon, Komath Damodaran, Thomas J. Macke, Reinaldo F. Gomez, Edgardo Laborde, Hugo O. Villar, James G. Keck, Steven R. Schow, Nancy Hsu, Lum Robert T, Danying Cai, Michael M. Wick, Graeme R. Martin, Paul Beroza
Publikováno v:
Journal of medicinal chemistry. 47(20)
We used protein affinity fingerprints to discover structurally novel inhibitors of cyclooxygenase-1 (COX-1) by screening a selected number of compounds, thus providing an alternative to extensive screening. From the affinity fingerprints of 19 known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990df7887fbbc53a76ec0a27ca3c84de
https://pubmed.ncbi.nlm.nih.gov/15369391
https://pubmed.ncbi.nlm.nih.gov/15369391
Autor:
Komath Damodaran, Paul Beroza, Randy M. Wadkins, Christopher L. Morton, Janice L. Hyatt, Philip M. Potter, Kyoung Jin P. Yoon, Richard E. Lee, Mary K. Danks
Publikováno v:
Molecular pharmacology. 65(6)
The dose-limiting toxicity of the highly effective anticancer agent 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (irinotecan; CPT-11) is delayed diarrhea. This is thought to be caused by either bacteria-mediated hydrolysis of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea7ee26eb337ca55662f8175b80d262
https://pubmed.ncbi.nlm.nih.gov/15155827
https://pubmed.ncbi.nlm.nih.gov/15155827
Autor:
M, Wadkins Randy, L, Hyatt Janice, P, Yoon Kyoung Jin, L, Morton Christopher, E, Lee Richard, Komath, Damodaran, Paul, Beroza, K, Danks Mary, M, Potter Philip
Publikováno v:
Molecular Pharmacology; June 2004, Vol. 65 Issue: 6 p1336-43, 8p