Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis

Autor: Ishida, Akiharu, Okabe, Yasuyuki, Matsushita, Takeshi, Sekiguchi, Tetsuya, Nishio, Takuya, Komagata, Tatsuya, Iwaki, Masanori, Miyata, Hidenori, Katagi, Jun, Naganawa, Atsushi, Maruyama, Toru, Imagawa, Akira

Publikováno v: In Bioorganic & Medicinal Chemistry 1 November 2021 49

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Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone-Inhibitory Effect of Octreotide after Growth Hormone-Releasing Hormone Stimulation.

Autor: Iida H; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.) hi.iida@ono.co.jp., Komagata T; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Tanaka H; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Nagasawa R; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Nishio T; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Shono T; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Kitagawa J; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Ogawara KI; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Shinozaki K; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Seki A; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Bruce M; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)., Ohno T; Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Dec; Vol. 379 (3), pp. 400-408. Date of Electronic Publication: 2021 Oct 01.