Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Kolyvanov, A."'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 57-61 (2024)
GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration.Methods. The study was conducted on outbred male rats. The conce
Externí odkaz:
https://doaj.org/article/be8d424ff7b74361aeb67c69dfbf0a4b
Autor:
O. Yu. Kravtsova, D. A. Dvoryaninov, G. B. Kolyvanov, A. A. Litvin, O. G. Gribakina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 27-31 (2024)
The pharmacokinetics of a new antiparkinsonian drug ADK-1113 after single intravenous and intragastric administrations in mice at doses of 10 and 20 mg/kg was studied. The absolute bioavailability was 10.1–16.3 % that indicates on potential possibi
Externí odkaz:
https://doaj.org/article/e506aa073e4040589c58ace1ed60986e
Autor:
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 41-47 (2024)
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues. The aim is to study the tissue availa
Externí odkaz:
https://doaj.org/article/5c7f5e8406504c54875dd3d0b9f6d420
Autor:
O. Yu. Kravtsova, O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 12-18 (2023)
The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intrave
Externí odkaz:
https://doaj.org/article/e8c497f291f7473f9c19ee94ffb123e4
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 37-45 (2022)
GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative determination of GIZh-298 in rat blood plasma has been developed and validated. The linear
Externí odkaz:
https://doaj.org/article/562d748deb1d4666a79264303ed54545
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 17-22 (2022)
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose
Externí odkaz:
https://doaj.org/article/5ca71ab2babf4e178b06dbb833a39cc2
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 31-35 (2022)
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates t
Externí odkaz:
https://doaj.org/article/3a4c660664214e5daed6a73af1144d8f
Autor:
P. O. Bochkov, I. P. Khrustova, A. A. Litvin, G. B. Kolyvanov, R. V. Shevchenko, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 3-10 (2022)
GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures of racetams that combine anticonvulsant and nootropic effects. The method of high-performance liquid chromatography with mass spectrometric detection was developed and valid
Externí odkaz:
https://doaj.org/article/63a5555a5add49528ba5775e7a283f70
Akademický článek
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Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-8 (2021)
The review discusses relationships between pharmacokinetic parameters and effects of psychotropic drugs, both in preclinical studies and clinical practice. The identification of such correlations can serve as a basis for understanding the complex sys
Externí odkaz:
https://doaj.org/article/bd57c01842a8456890065685d38b752c