Chemical modification patterns for microRNA therapeutic mimics: a structure-activity relationship (SAR) case-study on miR-200c.

Autor: Garreau M; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Weidner J; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Hamilton R; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Cambridge, UK., Kolosionek E; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Toki N; Translational Genomics, Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Stavenhagen K; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Paris C; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Bonetti A; Translational Genomics, Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Czechtizky W; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Gnerlich F; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Rydzik A; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Apr 12; Vol. 52 (6), pp. 2792-2807.

Gymnotic uptake of AntimiRs alter microRNA-34a levels in 2D and 3D epithelial cell culture.

Autor: Weidner J; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Kolosionek E; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Holmila R; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Ax E; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Garreau M; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Gnerlich F; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Olsson H; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Czechtizky W; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Vollmer S; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Rydzik AM; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2023 Aug 18; Vol. 33, pp. 898-907. Date of Electronic Publication: 2023 Aug 18 (Print Publication: 2023).

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.

Autor: Monkley S; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Overed-Sayer C; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Parfrey H; Cambridge Interstitial Lung Disease Service, Royal Papworth Hospital, Cambridge, UK., Rassl D; Royal Papworth Hospital, Cambridge, UK., Crowther D; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Escudero-Ibarz L; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Davis N; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Carruthers A; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Berks R; Biological Services Group, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Coetzee M; Babraham Institute, Cambridge, UK., Kolosionek E; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Karlsson M; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Griffin LR; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Clausen M; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Belfield G; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hogaboam CM; Cedars-Sinai Department of Medicine, Los Angeles, CA, 90048, USA., Murray LA; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. lynnemurray@hotmail.com.

Publikováno v: Scientific reports [Sci Rep] 2021 Nov 03; Vol. 11 (1), pp. 21584. Date of Electronic Publication: 2021 Nov 03.

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

Autor: Pullamsetti, S S, Banat, G A, Schmall, A, Szibor, M, Pomagruk, D, Hänze, J, Kolosionek, E, Wilhelm, J, Braun, T, Grimminger, F, Seeger, W, Schermuly, R T, Savai, R

Publikováno v: Oncogene; 2/28/2013, Vol. 32 Issue 9, p1121-1134, 14p, 1 Chart, 9 Graphs

Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling.

Autor: Ali Z; University of Kent, Medway School of Pharmacy, Chatham, Kent, UK., Kosanovic D; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany., Kolosionek E; University of Kent, Medway School of Pharmacy, Chatham, Kent, UK., Schermuly RT; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany., Graham BB; Department of Medicine, University of Colorado, Denver, CO, USA., Mathie A; University of Kent, Medway School of Pharmacy, Chatham, Kent, UK., Butrous G; University of Kent, Medway School of Pharmacy, Chatham, Kent, UK.

Publikováno v: Pulmonary circulation [Pulm Circ] 2017 Apr 04; Vol. 7 (1), pp. 244-252. Date of Electronic Publication: 2017 Apr 04 (Print Publication: 2017).