Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Kolja, Gelse"'
Autor:
Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/4a79129265f14a77a70418593018ffaa
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100124- (2020)
Objective: It is known that recombinant human gelsolin (rhuGSN) supports wound closure and migration processes in avascular tissue. Since articular cartilage degradation plays an important role in osteoarthritis (OA), we are investigating how rhuGSN
Externí odkaz:
https://doaj.org/article/86d0a6a91daf4f739e86cec99e3c9c06
Autor:
Jessica Feldt, Martin Schicht, Jessica Welss, Kolja Gelse, Stefan Sesselmann, Michael Tsokos, Eileen Socher, Fabian Garreis, Thomas Müller, Friedrich Paulsen
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 723 (2022)
Gelsolin (GSN) is an actin-binding protein involved in cell formation, metabolism and wound closure processes. Since this protein is known to play a role in arthritis, here we investigate how the synovial membrane with its specific synoviocytes contr
Externí odkaz:
https://doaj.org/article/d92a7dffee5a4ba1b2ff2c1c63c6a5ee
Autor:
Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation
Externí odkaz:
https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf
Autor:
Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ame
Externí odkaz:
https://doaj.org/article/9c56fd268be941fcb1e830810f66f437
Autor:
Nadine Hartjen, Lars Bräuer, Beate Reiß, Horst Claassen, Stephanie Beileke, Fabian Garreis, Sebastian Hoogeboom, Michael Tsokos, Saskia Etzold, Brigitte Müller-Hilke, Kolja Gelse, Thomas Müller, Mary B Goldring, Friedrich Paulsen, Martin Schicht
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203502 (2018)
OBJECTIVE:Surfactant Proteins (SPs) are well known from lung and form, along with phospholipids, a surface-active-layer at the liquid-air-interface of the alveolar lining. They play a major protective role by lowering surface tension, activating inna
Externí odkaz:
https://doaj.org/article/83069f23cab243c1b2cbb38fc2c379c9
Autor:
Thilo Hotfiel, Hans-Dieter Carl, Teresa Eibenberger, Kolja Gelse, Julian Weiß, Andreas Jendrissek, Bernd Swoboda
Publikováno v:
Journal of Orthopaedic Surgery, Vol 25 (2017)
Background: Total knee arthroplasty (TKA) has been established as a successful surgical treatment in the late stages of rheumatoid joint destruction. The purpose of this study was to review the clinical outcome and survivorship in rheumatoid arthriti
Externí odkaz:
https://doaj.org/article/842c2bef163a4fe68040434e5aa8be37
Autor:
Katharina Krüger, Sebastian Schmid, Friedrich Paulsen, Anita Ignatius, Patricia Klinger, Thilo Hotfiel, Bernd Swoboda, Kolja Gelse
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4277 (2019)
The aim of the study was to explore the possible role of Trefoil Factor Family peptide 3 (TFF3) for skeletal repair. The expression of TFF3 was analyzed in human joint tissues as well as in a murine bone fracture model. Serum levels of TFF3 following
Externí odkaz:
https://doaj.org/article/172fcffeddcf47bc82551b4a43f0b1a6
Autor:
Martin Stumpf, Jonas Biggemann, Tobias Fey, Axel J. Hueber, Gerhard Krönke, Arnd Kleyer, Carina Scholtysek, Anika Grüneboom, Melissa Halmheu, Kolja Gelse, Milena L Pachowsky
Publikováno v:
Tissue Engineering Part A. 25:1053-1062
The repair of large articular cartilage lesions is still a major challenge. In particular, the fixation of the grafts to the subchondral bone plate represents an unresolved problem. In this work, we present a completely novel concept based on a modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be265e0718865efb1b857ca8bc2e545c
https://doi.org/10.1089/ten.tea.2018.0231
https://doi.org/10.1089/ten.tea.2018.0231
Autor:
Wolfgang Zinser, Philipp Niemeyer, Gunter Spahn, Gunther O. Hofmann, Stefan Fickert, Kolja Gelse, Peter Angele, Julia Maurer, Dirk Albrecht, Jürgen Fritz, Suzanne Lungwitz
Publikováno v:
Zeitschrift für Orthopädie und Unfallchirurgie. 157:515-523
This study was aimed to determine the impact of bioregenerative operations in case of degenerative cartilage lesions within the media knee compartment.The CartilageRegistry DGOU was founded in 2013. At the deadline August 2016 a total of 1847 patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e4dcf21ca62a7ae607206711a40af
https://doi.org/10.1055/a-0820-6256
https://doi.org/10.1055/a-0820-6256