Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kolin M. Clark"'
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
HIV-1 usually utilizes CCR5 as its coreceptor and rarely switches to a CXCR4-tropic virus until the late stage of infection. CCR5+CD4+ T cells are the major virus-producing cells in viremic individuals as well as SIV-infected nonhuman primates. The d
Externí odkaz:
https://doaj.org/article/1d52a184f2b0487dbec57e03c2563c41
Publikováno v:
Nature Chemical Biology. 19:431-439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da4f3b157c70ad5249530689581fdf5a
https://doi.org/10.1038/s41589-022-01182-5
https://doi.org/10.1038/s41589-022-01182-5
Publikováno v:
Advances in Immunology ISBN: 9780443193286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1256e1fa1c686e19c08d3f2583cf15
https://doi.org/10.1016/bs.ai.2022.11.001
https://doi.org/10.1016/bs.ai.2022.11.001
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72d9ce26975d7e076c09ee09facec278
https://doi.org/10.1007/978-1-0716-3040-2_6
https://doi.org/10.1007/978-1-0716-3040-2_6
Publikováno v:
Nature chemical biology.
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1-infected CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbd89c49ff6476ca90b03849f30ea6e7
https://pubmed.ncbi.nlm.nih.gov/36357533
https://pubmed.ncbi.nlm.nih.gov/36357533
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1 infected CD4+T cells through induction of intracellular viral protease activation, which then activates the CARD8 inflammasome. Due to high concentrations of NNRTIs b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2a780425d34aaf80ec5604e4ac5b69
https://doi.org/10.1101/2021.09.01.458624
https://doi.org/10.1101/2021.09.01.458624
Autor:
Carl J. DeSelm, Kolin M. Clark, Hongbo Gao, Gray H. Harlan, Keanu Davis, Rachel M. Presti, Jack P. Tang, Christian Shema Mugisha, Liang Shan, Sebla B. Kutluay, Qiankun Wang
Publikováno v:
Science
Eradicating the last vestiges of HIV After treatment with antiretroviral therapy, HIV-1 wild-type and escape variants can persist in a latent form, especially within CD4 + T cells, hindering efforts to eradicate the virus. Q. Wang et al. found that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0be8c756b8cb476596bcef97a9b8a4
https://doi.org/10.1126/science.abe1707
https://doi.org/10.1126/science.abe1707
Autor:
Pengfei Tang, Hongbo Gao, Liang Shan, Rachel M. Presti, Sebla B. Kutluay, Gray H. Harlan, Kolin M. Clark, Qiankun Wang, Carl J. DeSelm
HIV-1 has high mutation rates and exists as mutant swarms in the host. Rapid evolution of HIV-1 allows the virus to outpace host immune system, leading to viral persistence. Novel approaches to target immutable components are needed to clear HIV-1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44af6770c2141d9f3e2854b110c0f33b
https://doi.org/10.1101/2020.09.25.308734
https://doi.org/10.1101/2020.09.25.308734