Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

Autor: Simone Rolfes, David A.D. Munro, Ekaterini-Maria Lyras, Eduardo Matute, Koliane Ouk, Christoph Harms, Chotima Böttcher, Josef Priller

Publikováno v: Neurobiology of Disease, Vol 144, Iss , Pp 105024- (2020)

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a trinucleotide (CAG) repeat expansion in the huntingtin gene (HTT). The R6/2 transgenic mouse model of HD expresses exon 1 of the human HTT gene with approximately 150 CA

Externí odkaz: https://doaj.org/article/37ce36bf12ec4689a5cca9af05cd20c5

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Autor: Ludovica Rigat, Koliane Ouk, Achim Kramer, Josef Priller

Publikováno v: Rigat, L, Ouk, K, Kramer, A & Priller, J 2023, ' Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease ', Acta Physiologica, pp. e13970 . https://doi.org/10.1111/apha.13970
Acta physiologica 238(2), e13970 (2023). doi:10.1111/apha.13970

Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and psychiatric disturbances. Although it is largely unclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0501a0a4007d5a08b43b8534930184
https://doi.org/10.1111/apha.13970

Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

Autor: Josef Priller, Simone Rolfes, Ekaterini-Maria Lyras, Koliane Ouk, David A. D. Munro, Eduardo Matute, Christoph Harms, Chotima Böttcher

Publikováno v: Neurobiology of disease 144, 105024 (2020). doi:10.1016/j.nbd.2020.105024
Neurobiology of Disease, Vol 144, Iss, Pp 105024-(2020)
Rolfes, S, Munro, D, Lyras, E-M, Matute, E, Ouk, K, Harms, C, Böttcher, C & Priller, J 2020, ' Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease ', Neurobiology of disease . https://doi.org/10.1016/j.nbd.2020.105024

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a trinucleotide (CAG) repeat expansion in the huntingtin gene (HTT). The R6/2 transgenic mouse model of HD expresses exon 1 of the human HTT gene with approximately 150 CA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95eec49ae86f405c893146f5c16cc354

Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease

Autor: Koliane Ouk, A. Jennifer Morton, Juliet Aungier, Marc Cuesta

Circadian abnormalities seen in Huntington's disease (HD) patients are recapitulated in several HD transgenic mouse models. In mice, alongside the master clock located in the suprachiasmatic nucleus (SCN), two other oscillators may influence circadia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942c9faf8f957c37a17dee3d3f95e1a4

Progressive gene dose-dependent disruption of the methamphetamine-sensitive circadian oscillator-driven rhythms in a knock-in mouse model of Huntington's disease

Autor: Juliet Aungier, A. Jennifer Morton, Koliane Ouk

Publikováno v: Experimental neurology. 286

Huntington's disease (HD) is a progressive genetic neurodegenerative disorder characterised by motor and cognitive deficits, as well as sleep and circadian abnormalities. In the R6/2 mouse, a fragment model of HD, rest-activity rhythms controlled by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c41edbbfcbe11e1666307a134bcf85
https://pubmed.ncbi.nlm.nih.gov/27646506