Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study.

Autor: Sharma S; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany. sapna.sharma@helmholtz-munich.de., Dong Q; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.; Faculty of Medicine, Ludwig-Maximilians-University München, Munich, Germany., Haid M; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany., Adam J; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München Neuherberg, Germany., Bizzotto R; Institute of Neuroscience, National Research Council, Padova, Italy., Fernandez-Tajes JJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Jones AG; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, UK., Tura A; Institute of Neuroscience, National Research Council, Padova, Italy., Artati A; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany., Prehn C; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany., Kastenmüller G; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany., Koivula RW; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Franks PW; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Malmö, Sweden., Walker M; Translational and Clinical Research Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK., Forgie IM; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Giordano G; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Malmö, Sweden., Pavo I; Eli Lilly Regional Operations GmbH, Vienna, Austria., Ruetten H; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany., Dermitzakis M; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.; Swiss Institute of Bioinformatics, Geneva, Switzerland., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Pedersen O; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schwenk JM; Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Solna, Sweden., Tsirigos KD; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., De Masi F; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Brunak S; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Viñuela A; Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK., Mari A; Institute of Neuroscience, National Research Council, Padova, Italy., McDonald TJ; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Adamski J; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Pearson ER; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany. harald.grallert@helmholtz-munich.de.; German Center for Diabetes Research (DZD), München Neuherberg, Germany. harald.grallert@helmholtz-munich.de.

Publikováno v: Diabetologia [Diabetologia] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30.

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study.

Autor: Eriksen R; Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK., White MC; Population Health & Genomics, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Dawed AY; Population Health & Genomics, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Perez IG; Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK., Posma JM; Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Health Data Research UK, London NW1 2BE, UK., Haid M; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), D-85764 Neuherberg, Germany., Sharma S; German Center for Diabetes Research, 85764 Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Bavaria, Germany., Prehn C; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), D-85764 Neuherberg, Germany., Thomas EL; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London W1W 6UW, UK., Koivula RW; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Skåne University Hospital, 221 00 Malmö, Sweden.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK., Bizzotto R; Institute of Neuroscience-National Research Council, 35127 Padua, Italy., Mari A; Institute of Neuroscience-National Research Council, 35127 Padua, Italy., Giordano GN; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Skåne University Hospital, 221 00 Malmö, Sweden., Pavo I; Eli Lilly Regional Operations GmbH, 1030 Vienna, Austria., Schwenk JM; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH-Royal Institute of Technology, SE-100 44 Stockholm, Sweden., De Masi F; Department of Health Technology, Kgs Lyngby and The Novo Nordisk Foundation Center for Protein Research, Technical University of Denmark, University of Copenhagen, 2200 Copenhagen, Denmark., Tsirigos KD; Department of Health Technology, Kgs Lyngby and The Novo Nordisk Foundation Center for Protein Research, Technical University of Denmark, University of Copenhagen, 2200 Copenhagen, Denmark., Brunak S; Department of Health Technology, Kgs Lyngby and The Novo Nordisk Foundation Center for Protein Research, Technical University of Denmark, University of Copenhagen, 2200 Copenhagen, Denmark.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark., Viñuela A; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McDonald TJ; NIHR Exeter Clinical Research Facility, Royal Devon & Exeter Hospital, Exeter EX2 5DW, UK., Kokkola T; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, FI-70211 Kuopio, Finland., Rutters F; Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC, 1007 Amsterdam, the Netherlands., Beulens J; Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC, 1007 Amsterdam, the Netherlands., Muilwijk M; Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC, 1007 Amsterdam, the Netherlands., Blom M; Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC, 1007 Amsterdam, the Netherlands., Elders P; Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC, 1007 Amsterdam, the Netherlands., Hansen TH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200 Copenhagen, Denmark., Fernandez-Tajes J; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Jones A; NIHR Exeter Clinical Research Facility, Royal Devon & Exeter Hospital, Exeter EX2 5DW, UK., Jennison C; Department of Mathematical Sciences, University of Bath, Bath BA2 7AY, UK., Walker M; Institute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne NE3 1DQ, UK., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LH, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200 Copenhagen, Denmark., Ruetten H; Sanofi-Aventis Deutschland GmbH, R&D, 65926 Frankfurt am Main, Germany., Forgie I; Population Health & Genomics, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Holst JJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Thomsen HS; Faculty of Medical and Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Ridderstråle M; Novo Nordisk Fonden Tuborg Havnevej 19, 2900 Hellerup, Denmark., Bell JD; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London W1W 6UW, UK., Adamski J; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), D-85764 Neuherberg, Germany.; Lehrstuhl für Experimentelle Genetik, Technische Universität München, 85350 Freising-Weihenstephan, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Franks PW; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Skåne University Hospital, 221 00 Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200 Copenhagen, Denmark., Holmes E; Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK., Frost G; Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK., Pearson ER; Population Health & Genomics, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Aug 13; Vol. 109 (9), pp. e1697-e1707.

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

Autor: Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy MI, Brunak S, ID Consortium

Publikováno v: Yearbook of Paediatric Endocrinology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53ee9c785e3efcf69df00756cae59ff
https://doi.org/10.1530/ey.19.15.4

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Autor: Atabaki-Pasdar, N, Ohlsson, M, Vinuela, A, Frau, F, Pomares-Millan, H, Haid, M, Jones, AG, Thomas, EL, Koivula, RW, Kurbasic, A, Mutie, PM, Fitipaldi, H, Fernandez, J, Dawed, AY, Giordano, GN, Forgie, IM, McDonald, TJ, Rutters, F, Cederberg, H, Chabanova, E, Dale, M, Masi, FD, Thomas, CE, Allin, KH, Hansen, TH, Heggie, A, Hong, M-G, Elders, PJM, Kennedy, G, Kokkola, T, Pedersen, HK, Mahajan, A, McEvoy, D, Pattou, F, Raverdy, V, Haussler, RS, Sharma, S, Thomsen, HS, Vangipurapu, J, Vestergaard, H, 't Hart, LM, Adamski, J, Musholt, PB, Brage, S, Brunak, S, Dermitzakis, E, Frost, G, Hansen, T, Laakso, M, Pedersen, O, Ridderstrale, M, Ruetten, H, Hattersley, AT, Walker, M, Beulens, JWJ, Mari, A, Schwenk, JM, Gupta, R, McCarthy, MI, Pearson, ER, Bell, JD, Pavo, I, Franks, PW

Publikováno v: PLoS Medicine, 17(6):e1003149. Public Library of Science
PLoS Medicine
Atabaki-Pasdar, N, Ohlsson, M, Viñuela, A, Frau, F, Pomares-Millan, H, Haid, M, Jones, A G, Louise Thomas, E, Koivula, R W, Kurbasic, A, Mutie, P M, Fitipaldi, H, Fernandez, J, Dawed, A Y, Giordano, G N, Forgie, I M, McDonald, T J, Rutters, F, Cederberg, H, Chabanova, E, Dale, M, de Masi, F, Thomas, C E, Allin, K H, Hansen, T H, Heggie, A, Hong, M G, Elders, P J M, Kennedy, G, Kokkola, T, Pedersen, H K, Mahajan, A, McEvoy, D, Pattou, F, Raverdy, V, Häussler, R S, Sharma, S, Thomsen, H S, Vangipurapu, J, Vestergaard, H, T Hart, L M, Adamski, J, Musholt, P B, Brage, S, Brunak, S, Dermitzakis, E, Frost, G, Hansen, T, Laakso, M, Pedersen, O, Ridderstråle, M, Ruetten, H, Hattersley, A T, Walker, M, Beulens, J W J, Mari, A, Schwenk, J M, Gupta, R, McCarthy, M I, Pearson, E R, Bell, J D, Pavo, I & Franks, P W 2020, ' Predicting and elucidating the etiology of fatty liver disease : A machine learning modeling and validation study in the IMI DIRECT cohorts ', PLoS Medicine, vol. 17, no. 6, e1003149 . https://doi.org/10.1371/journal.pmed.1003149
Atabaki-Pasdar, N, Ohlsson, M, Viñuela, A, Frau, F, Pomares-Millan, H, Haid, M, Jones, A G, Thomas, E L, Koivula, R W, Kurbasic, A, Mutie, P M, Fitipaldi, H, Fernandez, J, Dawed, A Y, Giordano, G N, Forgie, I M, McDonald, T J, Rutters, F, Cederberg, H, Chabanova, E, Dale, M, Masi, F D, Thomas, C E, Allin, K H, Hansen, T H, Heggie, A, Hong, M G, Elders, P J M, Kennedy, G, Kokkola, T, Pedersen, H K, Mahajan, A, McEvoy, D, Pattou, F, Raverdy, V, Häussler, R S, Sharma, S, Thomsen, H S, Vangipurapu, J, Vestergaard, H, 't Hart, L M, Adamski, J, Musholt, P B, Brage, S, Brunak, S, Dermitzakis, E, Frost, G, Hansen, T, Laakso, M, Pedersen, O, Ridderstråle, M, Ruetten, H, Hattersley, A T, Walker, M, Beulens, J W J, Mari, A, Schwenk, J M, Gupta, R, McCarthy, M I, Pearson, E R, Bell, J D, Pavo, I & Franks, P W 2020, ' Predicting and elucidating the etiology of fatty liver disease : A machine learning modeling and validation study in the IMI DIRECT cohorts ', PLoS Medicine, vol. 17, no. 6, pp. e1003149 . https://doi.org/10.1371/journal.pmed.1003149
PLoS Medicine, Vol 17, Iss 6, p e1003149 (2020)
PLoS Medicine, 17(6). PUBLIC LIBRARY SCIENCE

Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c1bc926a99b5302cc30d7245d0440117
https://research.vumc.nl/en/publications/f7988584-4096-47b4-b939-809f82641881

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.

Autor: Brown AA; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom., Fernandez-Tajes JJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom., Hong MG; Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Solna, SE-171 21, Sweden., Brorsson CA; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2100, Denmark., Koivula RW; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, United Kingdom., Davtian D; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom., Dupuis T; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom., Sartori A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland., Michalettou TD; Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 4EP, United Kingdom., Forgie IM; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom., Adam J; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Allin KH; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark., Caiazzo R; University of Lille, Inserm, Lille Pasteur Institute, Lille, France., Cederberg H; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., De Masi F; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Elders PJM; Department of General Practice, Amsterdam UMC- location Vumc, Amsterdam Public Health research institute, Amsterdam, The Netherlands., Giordano GN; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Malmö, Sweden., Haid M; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Hansen T; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark., Hansen TH; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark., Hattersley AT; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, EX25DW, United Kingdom., Heggie AJ; Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Howald C; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland., Jones AG; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, EX25DW, United Kingdom., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Laakso M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom., Mari A; Institute of Neuroscience, National Research Council, Padova, 35127, Italy., McDonald TJ; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, EX2 5DW, United Kingdom., McEvoy D; Diabetes Research Network, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Mourby M; Nuffield Department of Population Health, Centre for Health, Law and Emerging Technologies (HeLEX), University of Oxford, Oxford, OX2 7DD, United Kingdom., Musholt PB; Global Development, Sanofi-Aventis Deutschland GmbH, Hoechst Industrial Park, Frankfurt am Main, 65926, Germany., Nilsson B; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Pattou F; University of Lille, Inserm, Lille Pasteur Institute, Lille, France., Penet D; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland., Raverdy V; University of Lille, Inserm, Lille Pasteur Institute, Lille, France., Ridderstråle M; Department of Clinical Science, Lund University, Malmö, Sweden., Romano L; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland., Rutters F; Epidemiology and Data Science, VUMC, Amsterdam, The Netherlands., Sharma S; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany.; Food Chemistry and Molecular and Sensory Science, Technical University of Munich, München, Germany., Teare H; Centre for Health Law and Emerging Technologies, Department of Population Health, University of Oxford, Old Road Campus, Oxford, OX3 7DQ, United Kingdom., 't Hart L; Epidemiology and Data Science, VUMC, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Biomedical Data Sciences, Molecular Epidemiology section, Leiden University Medical Center, Leiden, The Netherlands., Tsirigos KD; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Vangipurapu J; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Vestergaard H; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark., Brunak S; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2100, Denmark., Franks PW; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Malmö, Sweden., Frost G; Nutrition and Dietetics Research Group, Imperial College London, London, SW7 2AZ, United Kingdom., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Jablonka B; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, 65926, Germany., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.; GENENTECH, 1 DNA Way, San Francisco, CA, 94080, USA., Pavo I; Eli Lilly Regional Operations Ges.m.b.H, Vienna, 1030, Austria., Pedersen O; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2100, Denmark., Ruetten H; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, 65926, Germany., Walker M; Translational and Clinical Research Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom., Adamski J; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Schwenk JM; Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Solna, SE-171 21, Sweden., Pearson ER; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland. emmanouil.dermitzakis@unige.ch.; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland. emmanouil.dermitzakis@unige.ch.; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland. emmanouil.dermitzakis@unige.ch., Viñuela A; Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 4EP, United Kingdom. ana.vinuela@newcastle.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Aug 21; Vol. 14 (1), pp. 5062. Date of Electronic Publication: 2023 Aug 21.