Výsledky vyhledávání - "Koki Hirashima"

Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect

Autor: Jun Ishihara, Tadashi Matsuda, Koki Hirashima, Mizuki Watanabe, Satoshi Shuto, Kohei Ishimura, Ryuta Muromoto, Yuto Murakami, Hayato Fukuda, Koichi Fujiwara

Publikováno v: ACS Med Chem Lett

[Image: see text] RvE1 (1) is an endogenous lipid mediator with very potent anti-inflammatory activity, which is due to the inhibition of neutrophil chemotaxis and inflammatory cytokine production and the promotion of macrophage phagocytosis. On the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0744efd940946db500b5e587a247c3
http://hdl.handle.net/2115/83926

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Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17–induced IκB-ζ expression

Autor: Yuka Saino, Ami Sato, Jun-ichi Kashiwakura, Yui Ohgakiuchi, Yuichi Kitai, Ryuta Muromoto, Koki Hirashima, Yuki Komori, Kenji Oritani, Tadashi Matsuda

Publikováno v: Biochemical and Biophysical Research Communications. 521:957-963

The signaling elicited by the cytokine interleukin-17A (IL-17) is important for antimicrobial defense responses, whereas excessive IL-17 production leads to autoimmune diseases such as psoriasis and multiple sclerosis. IL-17-induced stabilization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75033d98009e4d7ba33956d09dcce160
https://doi.org/10.1016/j.bbrc.2019.11.036

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IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17–Regulated mRNA Stabilization

Autor: Ami Sato, Yui Ohgakiuchi, Yuichi Kitai, Kenji Oritani, Kazuya Shimoda, Hiroya Minoguchi, Yuka Saino, Koki Hirashima, Ryuta Muromoto, Keisuke Tawa, Tadashi Matsuda, Jun-ichi Kashiwakura

Publikováno v: ImmunoHorizons. 3(5):172-185

Cytokine IL-17A (IL-17) acts on various cell types, including epidermal keratinocytes, and induces antimicrobial peptide and chemokine production to elicit antibacterial and antifungal defense responses. Excess IL-17 leads to inflammatory skin diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e7d07d45c1a730987f4f202a5d9089
http://hdl.handle.net/2115/82064

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Synthesis of Resolvin E3, a Proresolving Lipid Mediator, and Its Deoxy Derivatives: Identification of 18-Deoxy-resolvin E3 as a Potent Anti-Inflammatory Agent

Autor: Haruka Aoki-Saito, Koichi Fujiwara, Jun Ishihara, Koki Hirashima, Hayato Fukuda, Hiroyuki Ikeda, Satoshi Shuto, Mizuki Watanabe, Tadashi Matsuda, Kohei Ishimura, Takeshi Hisada, Ryuta Muromoto

Publikováno v: The Journal of organic chemistry. 85(21)

We synthesized RvE3 and its deoxy derivatives, 17-deoxy-RvE3 and 18-deoxy-RvE3, by a common route via Sonogashira coupling as a key step. The evaluation of their anti-inflammatory activities revealed that 18-deoxy-RvE3 was remarkably more potent than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f30345bd962890880671c61b0d1137
https://pubmed.ncbi.nlm.nih.gov/32942849

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Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents

Autor: Tadashi Matsuda, Satoshi Shuto, Jun Ishihara, Koki Hirashima, Hayato Fukuda, Kohei Ishimura, Yuto Murakami, Ryuta Muromoto, Koichi Fujiwara, Mizuki Watanabe

Publikováno v: ACS Med Chem Lett

[Image: see text] Resolvins (Rvs) are highly potent anti-inflammatory lipid mediators that are chemically and biologically unstable because of their polyunsaturated structures. To address this issue, we designed benzene congeners of RvE2, i.e., o-, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dfa44f444142286ef3e2776be54b9f
https://pubmed.ncbi.nlm.nih.gov/32292553

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A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3

Autor: Shigeyuki Kon, Naoki Matsumoto, Sumihito Togi, Ryuta Muromoto, Osamu Ikeda, Taichiro Okayama, Yuichi Sekine, Koki Hirashima, Yuichi Kitai, Tadashi Matsuda, Kenji Oritani

Publikováno v: Journal of Biological Chemistry (JBC). 291(21):11161-11171

Signal transducer and activator of transcription 3 (STAT3) is involved in cell proliferation, differentiation, and cell survival during immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3 activity is regulated by a va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3e71c7eb92d9ec413df1c9f95abce8
http://hdl.handle.net/2115/65506

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IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes

Autor: Koki Hirashima, Yuichi Kitai, Shigeyuki Kon, Keisuke Tawa, Ryuta Muromoto, Toru Hirao, Tadashi Matsuda

Publikováno v: International Immunology. 28:443-452

In psoriasis lesions, a diverse mixture of cytokines is up-regulated that influence each other generating a complex inflammatory situation. Although this is the case, the inhibition of IL-17A alone showed unprecedented clinical results in patients, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30914669130be446e1a2b2b8d03c3f6f
https://doi.org/10.1093/intimm/dxw011

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Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1

Autor: Tadashi Matsuda, Osamu Ikeda, Yuichi Kitai, Kenji Oritani, Eri Kawanishi, Ryuta Muromoto, Teruhito Yasui, Koki Hirashima, Yosuke Hatano, Shigeyuki Kon, Sumihito Togi

Publikováno v: FEBS Letters. 590:808-818

Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676f086a89cc2a97df08438ca73e8296
https://doi.org/10.1002/1873-3468.12119

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The mechanism of Tyk2 deficiency-induced immunosuppression in mice involves robust IL-10 production in macrophages

Autor: Jun-ichi Kashiwakura, Tadashi Matsuda, Tomohiro Matsumoto, Kazuya Shimoda, Kenji Oritani, Yuichi Kitai, Ryuta Muromoto, Hiroya Minoguchi, Koki Hirashima

Publikováno v: Cytokine. 130:155077

Macrophages are highly plastic in their pro-inflammatory/anti-inflammatory roles. Type I and II interferons (IFNs) are known to modulate macrophage activation. Tyrosine kinase 2 (Tyk2) has an intimate relationship with type I and II IFN signaling. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5adc08a33f380c67d5f8a238f8f008
http://hdl.handle.net/2115/82117

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