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Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1)

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:3662-3666

Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::095c494559927c4501b2a27cf758bee3
https://doi.org/10.1016/j.bmcl.2013.02.083

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A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations

Autor: Tsukasa Inaoka, Taro Yamauchi, Nao Nishida, Ryutaro Ohtsuka, Izumi Naka, Ryosuke Kimura, Yuji Ataka, Kazuhiro Nakayama, Yasuhiro Matsumura, Koki Hikami, Kazumi Natsuhara, Minori Koga, Sadahiko Iwamoto, Jun Ohashi, Minato Nakazawa, Takuro Furusawa, Takafumi Ishida, Naoyuki Tsuchiya

Publikováno v: International Journal of Obesity (2005)

OBJECTIVE:Obesity is a growing health concern in the Oceanic populations. To investigate the genetic factors associated with adult obesity in the Oceanic populations, the association of single nucleotide polymorphisms (SNPs) of the beta-2 adrenergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dc8313d4c82b606700aa225f2c4829
https://doi.org/10.1038/ijo.2012.206

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TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens

Autor: Saomi Murai, Isao Kaieda, Tomohiro Kawamoto, Zhe Nie, Maki Hasegawa, Takashi Sato, Erik Kupperman, Keisuke Kuida, Takashi Ichikawa, Lilly Zhang, Koki Hikami, Hitoshi Miyashita, Sheldon X. Cao, Yuichi Hikichi, Kouhei Honda, Johnny Yang, Noriko Uchiyama

Publikováno v: Molecular Cancer Therapeutics. 11:700-709

Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase involved in key processes during mitosis. Human PLK1 has been shown to be overexpressed in various human cancers, and elevated levels of PLK1 have been associated with poor prognosis, mak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa9636120376ef87977d2c35e5419b4
https://doi.org/10.1158/1535-7163.mct-11-0762

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Association of a functional polymorphism in the 3′-untranslated region of SPI1 with systemic lupus erythematosus

Autor: Koki Hikami, Satoshi Ito, Aya Kawasaki, Ikue Ito, Minori Koga, Isao Matsumoto, Hiroshi Hashimoto, Takayuki Sumida, Taichi Hayashi, Naoyuki Tsuchiya, Makio Kusaoi, Akito Tsutsumi, Yoshinari Takasaki, Tadao Arinami

Publikováno v: Arthritis & Rheumatism. 63:755-763

Objective SPI1, also referred to as PU.1, is an Ets family transcription factor that interacts with IRF2, IRF4, and IRF8. In view of the significance of the type I interferon pathway in systemic lupus erythematosus (SLE), this study was undertaken to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb496c1cfaa625adb3ad77d3481b2e61
https://doi.org/10.1002/art.30188

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Association of a functional polymorphism in theIRF5region with systemic sclerosis in a Japanese population

Autor: Kazuhiko Takehara, Yasushi Kawaguchi, Shinichi Sato, Manabu Fujimoto, Koki Hikami, Aya Kawasaki, Ikue Ito, Manabu Kawamoto, Masako Hara, Minoru Hasegawa, Naoyuki Tsuchiya, Jun Ohashi

Publikováno v: Arthritis & Rheumatism. 60:1845-1850

Objective Interferon regulatory factor 5, an established susceptibility factor for systemic lupus erythematosus (SLE), plays a role in type I interferon and proinflammatory cytokine induction. A recent study showed association of a functional single-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62dcac1b6fb7ad60f67cd37e562f3a9
https://doi.org/10.1002/art.24600

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Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis

Autor: Koki Hikami, Yukikazu Ehara, Kazuhiko Takehara, Katsushi Tokunaga, Takanori Oka, Masaki Matsushita, Shinichi Sato, Manabu Fujimoto, Minoru Hasegawa, Naoyuki Tsuchiya

Publikováno v: Biochemical and biophysical research communications. 373(3):403-407

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Interleukin-10 (IL-10) signaling has been suggested to play a role in systemic sclerosis (SSc). IL10RB codes for IL-10 receptor 2 (IL-10R2), a component shared in receptor complexes for IL-10, IL-22, IL-26 and interferon (IFN)-λ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf6200e699fd70cb9642bb51567806
https://tsukuba.repo.nii.ac.jp/records/16805

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Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis

Autor: Koki Hikami, Hiroto Kita, Hiroyuki Mutoh, Koichi Tsuneyama, Hiroko Hoshino, Yuichi Hikichi, Kentaro Sugano, Zheng-Guo Cui, Hirohide Ohnishi, Hiroyuki Osawa, Hironori Yamamoto, Christopher L. Bowlus

Publikováno v: Journal of Gastroenterology. 41:1053-1063

Flat adenomas in the colon are associated with a relatively higher potential for malignancy. Distinct genes may be involved in the development of flat adenoma. The aim of this study was to profile gene expression changes in flat adenomas in the colon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a8a06714c1a1e4aba44be158368bf0
https://doi.org/10.1007/s00535-006-1894-y

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Molecular genetic analyses of human NKG2C (KLRC2) gene deletion

Autor: Toru Fukazawa, Naoyuki Tsuchiya, Risa Miyashita, Kimiko Kuroki, Toshio Yabe, Marc Bijl, Katsushi Tokunaga, Cees G. M. Kallenberg, Koki Hikami, Hiroshi Hashimoto

Publikováno v: International immunology, 16(1), 163-168

Human NKG2A, NKG2C and NKG2E genes are located on 12p13 in the NK gene complex. We recently identified deletion of NKG2C in a Japanese population. This study was performed to identify the breakpoint, and to examine the association of NKG2C deletion w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5453fc045844100b087d3f2d2110e2
https://hdl.handle.net/11370/5d1b2b6b-355a-4793-acf3-50560c9ecb53

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Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms

Autor: Yoshinari Takasaki, Hiroshi Hashimoto, Katsushi Tokunaga, Chieko Kyogoku, Makio Kusaoi, Aya Kawasaki, Timothy W. Behrens, Risa Miyashita, Naoyuki Tsuchiya, Koki Hikami, Jun Ohashi

Publikováno v: Arthritis and rheumatism. 58(3)

Objective To determine whether the IRF5 gene, which encodes interferon regulatory factor 5, is associated with systemic lupus erythematosus (SLE) in a Japanese population. Methods A case–control study was performed in 277 SLE patients and 201 healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33db61a7306af7f77f3a00856abb781
https://pubmed.ncbi.nlm.nih.gov/18311811

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Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population

Autor: Katsushi Tokunaga, Toshio Yabe, Koki Hikami, Naoyuki Tsuchiya

Publikováno v: Genes and immunity. 4(2)

CD94 and NKG2 are members of the NK cell receptor families, and are encoded in the natural killer gene complex (NKC) on human chromosome 12p12–13, one of the candidate chromosomal regions for rheumatic diseases. To examine a possible association be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4649827573f817bd101f60a054a5b1
https://pubmed.ncbi.nlm.nih.gov/12618865

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