Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Koki Chiba"'
Autor:
Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Koichiro Tanaka, Yasunari Kanda, Takeshi Fukushima, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 3, Pp 154-162 (2022)
Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on cardiohemodynamic, electrocardiographic and echocardiographic variables along with biomarkers of
Externí odkaz:
https://doaj.org/article/fd87e9c0826943c79c0ee21cfceafe87
Autor:
Koki Chiba, Hiroshi Nomoto, Akinobu Nakamura, Kyu Yong Cho, Kumiko Yamashita, Yui Shibayama, Aika Miya, Hiraku Kameda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 2, Pp 176-183 (2021)
Abstract Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are used worldwide because of their multiple benefits for patients with type 2 diabetes. The purpose of this study was to determine the efficacy and safety of SGLT2i in p
Externí odkaz:
https://doaj.org/article/1dbe280944994136a7b013586e954b51
Autor:
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 272-280 (2020)
We analyzed the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action using the chronic atrioventricular block cynomolgus monkeys with a cross
Externí odkaz:
https://doaj.org/article/4d5879b7ed864747b2ffbcbe8292db4c
Autor:
Yoshio Nunoi, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Takeshi Wada, Hiroko Izumi-Nakaseko, Akio Matsumoto, Yoshinori Watanabe, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 1, Pp 56-59 (2020)
Since microminipig is becoming attractive model for various cardiac electropharmacological applications, which may meet consideration of 3Rs. We characterized microminipigs by analyzing how multi-ionic channel inhibitor bepridil may affect their in s
Externí odkaz:
https://doaj.org/article/9bfd317990a54441bb0042f86cddb70a
Autor:
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 4, Pp 172-175 (2020)
It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatmen
Externí odkaz:
https://doaj.org/article/6349e51ab0df4ef293e9e65a4072ce6d
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
The concept of “blood stasis” – called yū xiě in Chinese, Oketsu in Japanese – is one of the unique pathophysiology of traditional medicine that originated in China and inherited in Korea and Japan. This concept is related to the multiple a
Externí odkaz:
https://doaj.org/article/5613958777e540029db9d227f60b7dde
Autor:
Yoshio Nunoi, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Yoshinori Watanabe, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 330-332 (2020)
We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia wi
Externí odkaz:
https://doaj.org/article/6f71c1253a284e9488f82a1ec1612bb6
Autor:
Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Yasunari Kanda, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 1, Pp 86-89 (2019)
Information is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with IKr inhibitor-induced labile repolarization process. We compared the proarrhythmic effects of d-sotalol with those of dl-sotalo
Externí odkaz:
https://doaj.org/article/5a8478524afc4cdf8dd703cf29bee108
Autor:
Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Atsuhiko T. Naito, Yasunari Kanda, Akio Matsumoto, Hiroko Izumi-Nakaseko
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 4, Pp 317-320 (2019)
We investigated the electro-mechanical relationship of human iPS cell-derived cardiomyocyte sheets under arrhythmic condition, which was induced by digitalis intoxication along with the electrical train stimulation (n = 4). We adopted motion vector a
Externí odkaz:
https://doaj.org/article/5dda5c1dbb7c4db8a9b12850f636eac9
Autor:
Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Hiroko Izumi-Nakaseko
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 3, Pp 180-185 (2019)
We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca2+ uptake may affect cardiac electrophysiological properties in vivo by using caldaret which can decrease SR diastolic Ca2+ leak, enhance SR Ca2+ reuptake and inhibit reverse-mode N
Externí odkaz:
https://doaj.org/article/e316ea54747445f99be06ef857c40f71