Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kok Wai, Lam"'
Autor:
Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaludin, Kok Meng Chan
Publikováno v:
Genes and Environment, Vol 46, Iss 1, Pp 1-16 (2024)
Abstract Background Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, we further investigat
Externí odkaz:
https://doaj.org/article/6990a6906cfe4de2afd19b71f4a463bd
Autor:
Hilwan Yuda Teruna, Kamal Rullah, Rudi Hendra, Rahayu Utami, Deri Islami, Siti Munirah Mohd Faudzi, Mohd Fadhlizil Fasihi Mohd Aluwi, Kok Wai Lam
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2024 (2024)
Pinocembrin (PCB), a flavonoid known for its anti-inflammatory properties, has been approved for various clinical trial applications. To evaluate deeper into the anti-inflammatory potential of the specific enantiomer of natural PCB, we conducted the
Externí odkaz:
https://doaj.org/article/5ec484ec3c8f4286ab9756e217389bef
Autor:
Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaluddin, Kok Meng Chan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to o
Externí odkaz:
https://doaj.org/article/e4e3cc0d2d5e48809206806d4b379242
Autor:
Poh Yen, Khor, Stanslas, Johnson, Zhang, Tianshu, Li, Hongyuan, Wang, Xiaohui, Kok Meng, Chan, Kok Wai, Lam
Publikováno v:
In Bioorganic & Medicinal Chemistry September 2021
Autor:
Zi Han Loh, Huey Chong Kwong, Kok Wai Lam, Soek Sin Teh, Gwendoline Cheng Lian Ee, Ching Kheng Quah, Anthony Siong Hock Ho, Siau Hui Mah
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 627-639 (2021)
A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives posses
Externí odkaz:
https://doaj.org/article/b426022c0bd84b398e44a85d921c2c58
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity, inflammatory bowel disease, chronic obstructive pulmonary disease, ne
Externí odkaz:
https://doaj.org/article/a32c47fe91ad4de1a568e114c840659a
Publikováno v:
Metabolites, Vol 13, Iss 1, p 113 (2023)
The current therapeutic approach for gout is through the inhibition of the xanthine oxidase (XO) enzyme. Allopurinol, a clinically used XO inhibitor, causes many side effects. This study aimed to investigate the interaction between XO and inhibitors
Externí odkaz:
https://doaj.org/article/ed40c12072f54e0c800ea4408da47619
Autor:
Nur Zahirah Abd Rani, Endang Kumolosasi, Malina Jasamai, Jamia Azdina Jamal, Kok Wai Lam, Khairana Husain
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Moringa oleifera Lam. is a commonly used plant in herbal medicine and has various reported bioactivities such as antioxidant, antimicrobial, anticancer and antidiabetes. It is rich in nutrients and polyphenols. The plant also has
Externí odkaz:
https://doaj.org/article/40244482874b4cd58e89d8fff43ed1af
Publikováno v:
Insect Molecular Biology. 32:143-159
In Southeast Asia, Conopomorpha cramerella (Snellen) which is commonly known as the cocoa pod borer (CPB) moth has been identified as the most detrimental pest of Theobroma cacao L. Apart from the various side effects on human health and non-target o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbba6278ba1bff9404b9488450941138
https://doi.org/10.1111/imb.12820
https://doi.org/10.1111/imb.12820
Autor:
Kamal Rullah, Miah Roney, Zalikha Ibrahim, Nur Farisya Shamsudin, Deri Islami, Qamar Uddin Ahmed, Kok Wai Lam, Mohd Fadhlizil Fasihi Mohd Aluwi
Publikováno v:
Journal of Computational Biophysics and Chemistry. 22:77-97
This study explored a series of reported 5-lipoxygenase-activating protein (FLAP) inhibitors to understand their structural requirements and identify potential new inhibitor scaffolds through automated unbiased procedures. Docking studies have reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ac87d065dab3930c559deef3cce6a3
https://doi.org/10.1142/s2737416523500059
https://doi.org/10.1142/s2737416523500059