Výsledky vyhledávání - "Kok Pian Ang"

Abies spectabilis-Mediated Silver Nanoparticles Inhibits Cell Growth and Promotes Apoptosis in Breast Cancer MCF-7 Cells

Autor: Guanghui Ren, Xiaoyan Hao, Shuyi Yan, Jun Chen, Guobin Qiu, Kok Pian Ang, Mohd Islahuddin Mohd Tamrin

Publikováno v: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 41(1)

Breast cancer is the second most cause of mortality among women worldwide due to the uncontrolled proliferation of tumor cells in the mammary epithelial tissues. The silver nanoparticles were formulated from the Abies spectabilis leaf (AS-AgNPs) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3613acd070065bbfa2491bfcd72d0c8
https://pubmed.ncbi.nlm.nih.gov/35378005

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Antiproliferative activity exerted by tricyclohexylphosphanegold(I) n-mercaptobenzoate against MCF-7 and A2780 cell lines: the role of p53 signaling pathways

Autor: Pit Foong Chan, Roslida Abd Hamid, Kok Pian Ang

Publikováno v: BioMetals. 34:141-160

Based on the recent studies depicting the potential of heterometallic gold complexes as potent antiproliferative agents, herein we first reported the preliminary mechanistic data on the in-vitro antiproliferative activity of tricyclohexylphosphanegol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb45353cb6453800f673525c2026a73
https://doi.org/10.1007/s10534-020-00269-7

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Hypoxic-Mediated Oxidative Stress Condition and Hydroxyapatite-Inducing Osteogenic Differentiation of Human Mesenchymal Stem Cells: A Mathematical Modeling Study

Autor: Bala Sundaram Muthuvenkatachalam, Yu Sheng Qiu, Qiong Wu, Palanisamy Arulselvan, Guo Zhong He, Akon Higuchi, Sanjiv Rampal, K. B. Swamy, Rajan Mariappan, Pooi Ling Mok, Yan Chao Cui, Seoh Wei Teh, S. Suresh Kumar, Gang Bu, Zhong Sun, Kong Yong Then, Kok Pian Ang, Antony V. Samrot

Publikováno v: Journal of Biomedical Nanotechnology. 16:910-921

Avascular necrosis (AVN) of the bones remains a major clinical challenge. Fractures in the talus, the scaphoid, and the neck of the femur are especially challenging to heal due to the low blood vessel network and the lack of collateral blood supply.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c899deded1d36990d038dbb5610488c
https://doi.org/10.1166/jbn.2020.2939

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Induction of apoptosis on ovarian adenocarcinoma cells, A2780 by tricyclohexylphosphanegold (I) mercaptobenzoate derivatives via intrinsic and extrinsic pathways

Autor: Kok Pian Ang, Pit Foong Chan, Roslida Abd Hamid

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 26(7)

Tricyclohexylphosphanegold(I) n-mercaptobenzoate (n = 2, 3, 4) labelled as 1–3 were previously reported to significantly suppress thioredoxin reductase (TrxR) activities towards ovarian cancer cells, A2780, in vitro. Herein, we explored the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22183d8994b42e7f7062bc4c446bfe8f
https://pubmed.ncbi.nlm.nih.gov/34476610

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Metabolic utilization of human osteoblast cell line hFOB 1.19 under normoxic and hypoxic conditions: A phenotypic microarray analysis

Autor: Amira Peli, Mohammed Safwan Ali Khan, Badr Alzahrani, Narcisse Joseph, Seoh Wei Teh, Aisha Farhana, Antony V. Samrot, Suresh Kumar Subbiah, Kok Pian Ang, Yan Chao Cui, Yu Sheng Qiu, Avin Ee-Hwan Koh, Pooi Ling Mok, Gang Bu, Qiong Wu

Publikováno v: Exp Biol Med (Maywood)

Osteoblasts play an important role in bone regeneration and repair. The hypoxia condition in bone occurs when bone undergoes fracture, and this will trigger a series of biochemical and mechanical changes to enable bone repair. Hence, it is interestin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbf25cb1d26b88e1cfad80d52e77822
https://pubmed.ncbi.nlm.nih.gov/33535809

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10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities

Autor: Yiqiang Zhu, Qinwen Tai, Fa Fang, Yuanxi Wang, Jinhui Zhang, Junsheng Kang, Feng Zhong, Kok Pian Ang, Feng Gao, Kah Kooi Ooi, Liquan Cai, Yi Gao

Publikováno v: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 38(4)

Early development of liver cancer is usually asymptomatic. The overall survival rate of patients is relatively low due to late diagnosis, despite hepatocellular carcinoma being a common diagnosis. The high mortality rate of liver cancer was due to it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f8dcf1ae75898f7d8660059125515d
https://pubmed.ncbi.nlm.nih.gov/32464002

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10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

Autor: Wenzhi Zhang, Jianxin Zhang, Krystian Pluta, Małgorzata Jeleń, Chen Ming, Kok-Pian Ang, Beata Morak-Młodawska, Kah Kooi Ooi, Abdah Md Akim, Patrick Nwabueze Okechukwu

Publikováno v: Drug Design, Development and Therapy. 11:3045-3063

The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the fundamental chemotherapy provides promising anticancer activities, it is associated with severe side

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e51ecb8cbef777833ebb589473e946f4
https://doi.org/10.2147/dddt.s144415

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G 2 /M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph 3 PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

Autor: Chien Ing Yeo, Kok Pian Ang, Kah Kooi Ooi, Abdah Md Akim, Edward R. T. Tiekink, Theventhiran Mahandaran, Hoi-Ling Seng, Yoke Kqueen Cheah

Publikováno v: Journal of Inorganic Biochemistry. 166:173-181

Phosphanegold(I) thiolates, Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), were previously shown to be significantly cytotoxic toward HT-29 cancer cells and to induce cell death by both intrinsic and extrinsic apoptotic pathways whereby 1 acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fdbad4a8f75d39bc7c2935bb41dfa41
https://doi.org/10.1016/j.jinorgbio.2016.11.008

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Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro

Autor: Muhammad Nazrul Hakim, Lai Yen Fong, Kok Pian Ang, Gwendoline Cheng Lian Ee, Nor Hayuti Mohd Hussain, Nurul Ain Abu Bakar, Chin Theng Ng, Zuraini Ahmad

Publikováno v: The Journal of Physiological Sciences. 66:213-220

Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6918a63956da5335477a8c7e14d140c6
https://doi.org/10.1007/s12576-015-0410-7

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