Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kok Hao Chen"'
Autor:
Xinrui Zhou, Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract High-dimensional, spatially resolved analysis of intact tissue samples promises to transform biomedical research and diagnostics, but existing spatial omics technologies are costly and labor-intensive. We present Fluorescence In Situ Hybridi
Externí odkaz:
https://doaj.org/article/284aa504ea2f42378e48e19f18aca8a9
Autor:
Xinrui Zhou, Wan Yi Seow, Norbert Ha, Teh How Cheng, Jiang Lingfan, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen
High-dimensional, spatially resolved analysis of intact tissue samples promises to transform biomedical research and diagnostics, but existing spatial omics technologies are costly and labor-intensive. We present FISHnCHIPs for highly sensitivein sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3e73d055f6b444c794949941846147
https://doi.org/10.1101/2023.04.11.536345
https://doi.org/10.1101/2023.04.11.536345
Autor:
Vipul Singhal, Nigel Chou, Joseph Lee, Jinyue Liu, Wan Kee Chock, Li Lin, Yun-Ching Chang, Erica Teo, Hwee Kuan Lee, Kok Hao Chen, Shyam Prabhakar
Each cell type in a solid tissue has a characteristic transcriptome and spatial arrangement, both of which are observable using modern spatial omics assays. However, the common practice is still to ignore spatial information when clustering cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2640f6ec7bf100378628ae358922646
https://doi.org/10.1101/2022.04.14.488259
https://doi.org/10.1101/2022.04.14.488259
Autor:
Nigel Chou, Kok Hao Chen, Jolene Jie Lin Goh, Yun Ching Chang, Wan Yi Seow, Norbert Ha, Ziqing W. Zhao, Chung Pui Paul Cheng
Publikováno v:
Nature Methods. 17:689-693
We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to achieve enhanced specificity. Split-FISH reduces off-target background fluorescence, decreases false positives and enables accurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d3afbd2621e5f61695013711648a46
https://doi.org/10.1038/s41592-020-0858-0
https://doi.org/10.1038/s41592-020-0858-0
Autor:
Huipeng Li, Elise T. Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J. K. Wee, Axel M. Hillmer, Iain Beehuat Tan, Paul Robson, Shyam Prabhakar
Publikováno v:
Nature Genetics. 55:166-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea8f50686371a3591e5684dac4475739
https://doi.org/10.1038/s41588-022-01281-y
https://doi.org/10.1038/s41588-022-01281-y
Autor:
Jolene Jie Lin, Goh, Nigel, Chou, Wan Yi, Seow, Norbert, Ha, Chung Pui Paul, Cheng, Yun-Ching, Chang, Ziqing Winston, Zhao, Kok Hao, Chen
Publikováno v:
Nature methods. 17(7)
We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to achieve enhanced specificity. Split-FISH reduces off-target background fluorescence, decreases false positives and enables accurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f26f2899b99a257ebe16eb8b2455d192
https://pubmed.ncbi.nlm.nih.gov/33214708
https://pubmed.ncbi.nlm.nih.gov/33214708
Autor:
Kok Hao Chen1, Boettiger, Alistair N.1, Moffitt, Jeffrey R.1, Siyuan Wang1, Xiaowei Zhuang1,2 zhuang@chemistry.harvard.edu
Publikováno v:
Science. 4/24/2015, Vol. 348 Issue 6233, p1-14. 15p.
Autor:
Nigel Chou, Kok Hao Chen, Jolene Jie Lin Goh, Yun Ching Chang, Chung Pui Paul Cheng, Norbert Ha, Ziqing W. Zhao, Wan Yi Seow
Publikováno v:
Nature Methods. 18:114-114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cccae9136ed403bad76028565ae5a96a
https://doi.org/10.1038/s41592-020-01019-w
https://doi.org/10.1038/s41592-020-01019-w
Autor:
Jolene Jie Lin Goh, Nigel Chou, Wan Yi Seow, Norbert Ha, Chung Pui Paul Cheng, Yun-Ching Chang, Ziqing Winston Zhao, Kok Hao Chen
Publikováno v:
Nature Methods. 17:947-947
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74719cf7d0e04909e3571aed15aae99
https://doi.org/10.1038/s41592-020-0931-8
https://doi.org/10.1038/s41592-020-0931-8
Autor:
Iain Beehuat Tan, Axel M. Hillmer, Lim Kiat Hon, Debarka Sengupta, Shyam Prabhakar, Wah Siew Tan, Yuliana Tan, Kok Hao Chen, Clarinda Chua, Jolene Jie Lin Goh, Paul Jongjoon Choi, Lawrence J K Wee, Paul Robson, Mark T. C. Wong, Say Li Kong, Elise T. Courtois, Huipeng Li
Publikováno v:
Nature genetics. 49(5)
Intratumoral heterogeneity is a major obstacle to cancer treatment and a significant confounding factor in bulk-tumor profiling. We performed an unbiased analysis of transcriptional heterogeneity in colorectal tumors and their microenvironments using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec4dd1c578d0c0a63c4774868884e2c
https://pubmed.ncbi.nlm.nih.gov/30420650
https://pubmed.ncbi.nlm.nih.gov/30420650