Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kojo Arita"'
Publikováno v:
International Journal of Hematology. 114:8-17
Oral iron preparations are used as first-line treatment for iron deficiency anemia (IDA), but their gastrointestinal side effects prevent patients from appropriate adherence. We recently conducted a randomized, double-blind, phase 3 non-inferiority s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb506f22df4d35b90f8a3ff4f450c8a3
https://doi.org/10.1007/s12185-021-03123-9
https://doi.org/10.1007/s12185-021-03123-9
Autor:
Akihiro Nomura, Kojo Arita, Paul D. Crowe, Kazuyuki Hirata, Makoto Shiozaki, Keisuke Ito, Naoki Miyagawa, Yoshiaki Katsuda, Kota Asahina, Hiromasa Hashimoto, Yoshihiro Suwa, Masayuki Kotoku, Haiyan Tao, Yasunori Hase, Yokota Masahiro, Seki Noriyoshi, Fujioka Shingo, Satoki Doi, Tsuyoshi Adachi, Masato Noguchi, Scott M. Thacher, Takayoshi Suzuki, Taku Ikenogami, Takaki Maeba
Publikováno v:
Journal of medicinal chemistry. 62(5)
Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial motifs in conjunction with scaffold hopping was examined, resulting in discovery of the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d47ae0da2d592b09541af2e19b99f9f
https://pubmed.ncbi.nlm.nih.gov/30776227
https://pubmed.ncbi.nlm.nih.gov/30776227
Publikováno v:
The Kobe journal of medical sciences. 62(4)
Psoriasis is a chronic inflammatory skin disease mediated by dysregulated auto-reactive immune system. In this study, in order to confirm and further extend the pharmacological basis of topical steroids in psoriasis therapy, we investigated the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8fd610507ff2978936bf411f4b1ce86
https://pubmed.ncbi.nlm.nih.gov/28239073
https://pubmed.ncbi.nlm.nih.gov/28239073
Autor:
Kojo Arita, Tomonori Kaifu, Masanobu Satake, Kazuyoshi Kohu, Toshiyuki Takai, Kohji Kitaguchi, Hidetaka Ohmori, Akira Nakamura, Shota Endo
Publikováno v:
The Journal of Immunology. 186:7050-7059
Cells in the immune system are regulated positively or negatively by sets of receptor pairs that conduct balanced, activating, or inhibitory intracellular signaling. One such receptor pair termed paired Ig-like receptor (PIR) is composed of the inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda0a42c5e7990c2429240903ced723
https://doi.org/10.4049/jimmunol.1001302
https://doi.org/10.4049/jimmunol.1001302
Autor:
Naoki Miyagawa, Kota Asahina, Shintaro Hirashima, Scott Thacher, Satoki Doi, Masayuki Kotoku, Yukihiro Nomura, Katsuya Maeda, Shingo Obika, Haiyan Tao, Erin Bradley, Yoshiaki Katsuda, Paul Crowe, Seki Noriyoshi, Ruo Steensma, Takahiro Hata, Tsuyoshi Adachi, Robert Babine, Sakai Takayuki, Makoto Shiozaki, Kojo Arita, Masato Noguchi, Takaki Maeba, Xiaolin Li, Yasunori Hase, Morgan Fenn, Kazuyuki Hirata, Masafumi Kamada, Yusuke Aratsu, Akimi Hori, Takayuki Yamaguchi, Hiromasa Hashimoto
A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a980bfa040ac0bdac6e9c6c9a5fd8c0
https://europepmc.org/articles/PMC4716592/
https://europepmc.org/articles/PMC4716592/
