Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kojiro Mukai"'
Autor:
Toshiki Mori, Takahiro Niki, Yasunori Uchida, Kojiro Mukai, Yoshihiko Kuchitsu, Takuma Kishimoto, Shota Sakai, Asami Makino, Toshihide Kobayashi, Hiroyuki Arai, Yasunari Yokota, Tomohiko Taguchi, Kenichi G. N. Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Sphingomyelin (SM) is a major sphingolipid in mammalian cells. SM is enriched in the extracellular leaflet of the plasma membrane (PM). Besides this localization, recent electron microscopic and biochemical studies suggest the presence of SM
Externí odkaz:
https://doaj.org/article/73e0b0823723421e9a72b1b044b58f5a
Autor:
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, Takuma Kishimoto, Kazuma Tanaka, Yasunari Yokota, Hiroyuki Arai, Kenichi G. N. Suzuki, Tomohiko Taguchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence re
Externí odkaz:
https://doaj.org/article/849720d0fa4c450ab8549105c9a57319
Autor:
Chiaki Inoue, Kojiro Mukai, Tatsuyuki Matsudaira, Jun Nakayama, Nozomu Kono, Junken Aoki, Hiroyuki Arai, Yasunori Uchida, Tomohiko Taguchi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Yes-associated protein (YAP) is a transcriptional coactivator that is essential for the malignancy of various cancers. We have previously shown that YAP activity is positively regulated by phosphatidylserine (PS) in recycling endosomes (REs)
Externí odkaz:
https://doaj.org/article/8d6cacaebed848179498734751cbfd5d
Autor:
Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tetsuya Hirabayashi, Kojiro Mukai, Kohji Kasahara, Keiyo Takubo, Nobuhito Goda, Koichi Honke, Tomohiko Taguchi, Hiroyuki Sorimachi, Noriko Toyama-Sorimachi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role of this interaction is uncertain. Ly49Q, an atypical Ly49 rece
Externí odkaz:
https://doaj.org/article/70ff05ea7c2b4300b918de175f128002
Autor:
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 161-174 (2023)
Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activitie
Externí odkaz:
https://doaj.org/article/96f940d7a0ec4d6eb66092a8c3263bfc
Autor:
Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi
Publikováno v:
Cell Structure and Function, Vol 48, Iss 1, Pp 59-70 (2022)
Stimulator of interferon genes (STING) is an ER-localized transmembrane protein and the receptor for 2',3'-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), which is a second messenger produced by cGAMP synthase (cGAS), a cytosolic do
Externí odkaz:
https://doaj.org/article/107fff2f745949abad01f44bf228cfb1
Publikováno v:
Cell Structure and Function, Vol 47, Iss 1, Pp 19-30 (2022)
Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA or self-DNA leaked from mitochondria/nuclei. In response to the emergence of such DNAs in the cytosol, STING relocates from the endoplasmi
Externí odkaz:
https://doaj.org/article/de66b5ba7b544c8d86b3a2e2143f2845
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of-function mutations in STING have been identified in patients with STI
Externí odkaz:
https://doaj.org/article/8640eba5e72c469bb4823d58e8006b47
Autor:
Kanoko Takahashi, Takahiro Niki, Emari Ogawa, Kiku Fumika, Yu Nishioka, Masaaki Sawa, Hiroyuki Arai, Kojiro Mukai, Tomohiko Taguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from virus or self-DNA from mitochondria/nuclei. In response to emergence of such DNAs in the cytosol, STING translocates from th
Externí odkaz:
https://doaj.org/article/d0e2578f1c324ddc8a46d5d697abf0e7
Autor:
Kojiro Mukai, Emari Ogawa, Rei Uematsu, Yoshihiko Kuchitsu, Fumika Kiku, Takefumi Uemura, Satoshi Waguri, Takehiro Suzuki, Naoshi Dohmae, Hiroyuki Arai, Anthony K. Shum, Tomohiko Taguchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS
Externí odkaz:
https://doaj.org/article/5f2b94b366d546d681b2cdd4058de2b2