Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Koji Urakami"'
Publikováno v:
Analytical Chemistry. 84:2373-2379
Minor N-linked glycans containing N-glycolylneuraminic acid residues and/or α-Gal epitopes (i.e., galactose-α1,3-galactose residues) have been reported to be present in recombinant monoclonal antibody (mAb) therapeutics. These contaminations are du
Autor:
Masayuki Godo, Kazuichi Umemoto, Takahiro Ueno, Koji Urakami, Keisuke Kitamura, Atsuya Higashi
Publikováno v:
YAKUGAKU ZASSHI. 125:807-814
The feasibility of a simple Fourier transform (FT)Raman spectroscopic method for the quantitative determination of unexpected active drug polymorphs or amorphous in drug products was explored. In this study, calibration samples were prepared by ph
Autor:
Koji Urakami
Publikováno v:
Current Pharmaceutical Biotechnology. 6:193-203
A great number of pharmaceutical substances exist in crystalline solid-state. Because of the complexity of their chemical structure many different polymorphs of a given substance can exist. Polymorphic forms of solid pharmaceuticals influence not onl
Publikováno v:
Thermochimica Acta. 424:157-163
The enthalpies of solute transfer from an HPLC mobile phase to the stationary phase were directly determined by flow microcalorimetry, i.e., without preparation of van’t Hoff plots based on the temperature dependence of chromatographic retention da
Publikováno v:
Journal of Chromatography A. 1057:203-210
The influence of the matrix medium used for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography was investigated. The purpose of this paper is to propose a guide for the choice of a matrix medium suitable
Publikováno v:
Thermochimica Acta. 420:19-22
This paper discusses the theory and experimental application of microcalorimetry to the study of solid state reactions of pharmaceutical importance. The practical example selected is that of formulated products containing benzoyl peroxide – a treat
Autor:
Anthony E. Beezer, Koji Urakami
Publikováno v:
Thermochimica Acta. 410:109-117
This paper reports a technique for heat conduction isothermal microcalorimeters, which allows, by means of a lowering apparatus, the sample and reference ampoules to be lowered very slowly from the pre-equilibration position to the measuring position
Autor:
Michael A. A. O'Neill, Koji Urakami, Richard J. Willson, JA Connor, Anthony E. Beezer, Andrew C. Morris
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 73:709-714
Several recent publications from this laboratory have reported developments in the capacity to calculate thermodynamic and kinetic parameters, such as rate constant, enthalpy, order of reaction, from isothermal micro-calorimetric data. To date these
Publikováno v:
Bulletin of the Chemical Society of Japan. 75:1241-1245
The transition temperature for enantiotropic polymorphs of pharmaceutical drugs was estimated by measuring the heat of solution and solubility at 25 °C. Instead of the conventional estimation method using van’t Hoff plots, a thermodynamic formula
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:263-267
A novel method for thermodynamic stability studies of polymorphic drug substances has been developed. In order to estimate the transition temperature for an enantiotropic polymorphic pair, a formula for calculating the temperature at which the solubi