Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Koji Sugiura"'
Autor:
Natsumi MARUYAMA, Isuzu FUKUNAGA, Tomoaki KOGO, Tsutomu ENDO, Wataru FUJII, Masami KANAI-AZUMA, Kunihiko NAITO, Koji SUGIURA
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 6, Pp 328-336 (2023)
Senescent cells play a detrimental role in age-associated pathogenesis by producing factors involved in senescence-associated secretory phenotype (SASP). The present study was conducted to examine the possibility that senescent cells are present in a
Externí odkaz:
https://doaj.org/article/eff58900710e4b729aaf3ea407fecaab
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 5, Pp 270-278 (2023)
The signals of the transforming growth factor β (TGF-β) superfamily play a critical role in follicular development in mammals. ACVR1B/TGFBR1/ACVR1C receptors mediate the signaling of several TGF-β superfamily ligands in granulosa cells. Although t
Externí odkaz:
https://doaj.org/article/84d386a84e5f407b9a3c87f721ea760e
Autor:
Haruka Ito, Chihiro Emori, Mei Kobayashi, Natsumi Maruyama, Wataru Fujii, Kunihiko Naito, Koji Sugiura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Forkhead box L2 (FOXL2) plays a critical role in the development and function of mammalian ovaries. In fact, the causative effects of FOXL2 misregulations have been identified in many ovarian diseases, such as primary ovarian insufficiency a
Externí odkaz:
https://doaj.org/article/37d9679921134fe1be3503b9dbe514c3
Autor:
Chihiro EMORI, Takuya KANKE, Haruka ITO, Yuki AKIMOTO, Wataru FUJII, Kunihiko NAITO, Koji SUGIURA
Publikováno v:
The Journal of Reproduction and Development, Vol 68, Iss 2, Pp 137-143 (2022)
The cooperative effects of estrogen and oocyte-derived paracrine factors (ODPFs) play critical roles in the normal development of ovarian follicles; however, the mechanism underlying this cooperation has not been well studied. The present study aimed
Externí odkaz:
https://doaj.org/article/fdc1ead1304b46518cf666bf452f5879
Publikováno v:
Reproductive Medicine and Biology, Vol 22, Iss 1, Pp n/a-n/a (2023)
Abstract Background Development of ovarian follicles is regulated by a complex interaction of intra‐ and extra‐follicular signals. Oocyte‐derived paracrine factors (ODPFs) play a central role in this process in cooperation with other signals. M
Externí odkaz:
https://doaj.org/article/97b47c91a85e4dd2b740d84c72934cd5
Publikováno v:
The Journal of Reproduction and Development, Vol 65, Iss 5, Pp 407-412 (2019)
Exportin 6, which functions specifically in the nuclear export of actin family proteins, has been reported to be absent in immature Xenopus oocytes, which have a huge nucleus containing a large amount of actin. In mammalian oocytes, however, the pres
Externí odkaz:
https://doaj.org/article/cdd65bf23d7c4da193cfe1a052dfbacb
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217760 (2019)
Extracellular vesicles such as exosomes contain several types of transcripts, including mRNAs and micro RNAs (miRNAs), and have emerged as important mediators of cell-to-cell communication. Exosome-like vesicles were identified in the ovarian follicl
Externí odkaz:
https://doaj.org/article/b753058e9b4c4eef9bcc193598be71f7
Publikováno v:
WIT Transactions on The Built Environment.
Publikováno v:
Molecular reproduction and developmentREFERENCES. 89(7)
The expansion of cumulus cells associated with oocytes is an essential phenomenon in normal mammalian ovulation. Indeed, attenuated expression of cumulus expansion-related genes, including Has2, Ptgs2, Ptx3, and Tnfaip6, results in ovulation failure,
Publikováno v:
Biology of Reproduction. 103:85-93
Cumulus cells and mural granulosa cells (MGCs) play distinct roles during follicular development, and normal development of these cell lineages is critical for the female fertility. Transcriptomic diversification between the two cell lineages is obvi