Výsledky vyhledávání

A Novel Combretastatin A-4 Derivative, AC-7700, Shows Marked Antitumor Activity against Advanced Solid Tumors and Orthotopically Transplanted Tumors

Autor: Yasufumi Sato, Yukio Akiyama, Akira Okano, Katsuyoshi Hori, Toshihiro Hatanaka, Takashi Tsuruo, Kazuo Ohishi, Sachiko Saito, Takashi Tsuji, Yukio Nihei, Yasuyo Suga, Ryusuke Nakagawa, Yoshihiro Morinaga, Koji Ohsumi

Publikováno v: Japanese Journal of Cancer Research : Gann

AC-7700, a novel combretastatin A-4 derivative, suppresses the growth of solid tumors by inhibiting tumor perfusion. We evaluated the antitumor activity of AC-7700 on solid tumors in two experimental models, an advanced tumor model (murine colon 26 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b216d5df7547a8fe75c2648e5cba4c3
https://doi.org/10.1111/j.1349-7006.1999.tb00850.x

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Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity

Autor: Koji Ohsumi, Yukio Nihei, Koichi Fujita, Takashi Tsuji, Toshihiro Hatanaka, Ryusuke Nakagawa, Yasuyo Suga, Yukio Akiyama, Yumiko Fukuda

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:3371-3374

A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173d0d3329eb83eeff0354297f78c67e
https://doi.org/10.1016/s0960-894x(98)00622-2

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Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues

Autor: Takashi Tsuji, Ryusuke Nakagawa, Yoshihiro Morinaga, Koji Ohsumi, Yukio Akiyama, Toshihiro Hatanaka, Yumiko Fukuda, Yukio Nihei, Koichi Fujita, Yasuyo Suga

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:3153-3158

A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb695992ccc5341d403d4b2ae3fdf87
https://doi.org/10.1016/s0960-894x(98)00579-4

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Potentiation of antitumor and antimetastatic activities of adriamycin by a novel N-alkylated dihydropyridine, AC394, and its enantiomers in colon cancer-bearing mice

Autor: Koji Ohsumi, Yoshihiro Morinaga, Ohishi K, Yasuyo Suga, Takashi Tsuji, Ryusuke Nakagawa, Yukio Akiyama, Takashi Tsuruo

Publikováno v: Cancer Chemotherapy and Pharmacology. 38:446-452

Purpose: We have previously shown that a series of N-alkylated 1,4-dihydropyridines potentiate the therapeutic efficacy of vincristine in vincristine-resistant P388 leukemia. The purpose of this study was to investigate the ability of one of the comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfc3121120409555be784c99a955f88
https://doi.org/10.1007/s002800050509

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N-Alkylated 1,4-Dihydropyridines: New Agents to Overcome Multidrug Resistance

Autor: Takaaki Sekiyama, Yoshihiro Morinaga, Kazuo Ohishi, Takashi Tsuji, Koji Ohsumi, Takashi Tsuruo, Yukio Akiyama, Yasuyo Suga, Ryusuke Nakagawa

Publikováno v: Chemical and Pharmaceutical Bulletin. 43:818-828

New N-alkylated 1,4-dihydropyridine derivatives were synthesized and their ability to overcome multidrug resistance was examined in vincristine-resistant P388 cells (P388/VCR cells). Compounds that possessed an arylalkyl substituent on the dihydropyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005e6e0019d544da1c23a41b2ff435d7
https://doi.org/10.1248/cpb.43.818

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ChemInform Abstract: N-Alkylated 1,4-Dihydropyridines: New Agents to Overcome Multidrug Resistance

Autor: Takashi Tsuji, Yukio Akiyama, Yoshihiro Morinaga, Takashi Tsuruo, Koji Ohsumi, Takaaki Sekiyama, Ryusuke Nakagawa, Kazuo Ohishi, Yasuyo Suga

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbc462f1eafa9be9894646100880fa9d
https://doi.org/10.1002/chin.199545168

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ChemInform Abstract: Novel Combretastatin Analogues Effective Against Murine Solid Tumors: Design and Structure-Activity Relationships

Autor: Koji Ohsumi, Yasuyo Suga, Toshihiro Hatanaka, Takashi Tsuji, Yukio Akiyama, Yumiko Fukuda, Yukio Nihei, Kazuo Ohishi, Ryusuke Nakagawa, Yoshihiro Morinaga

Publikováno v: ChemInform. 29

A series of combretastatin A-4 (CA-4) analogues were synthesized, and their cytotoxic effects against murine Colon 26 adenocarcinoma and inhibitory activity on tubulin polymerization were evaluated. Since CA-4 has limited aqueous solubility, the targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b8b1e572eb17af2725e1bf692bffbf0
https://doi.org/10.1002/chin.199848088

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ChemInform Abstract: Novel B-Ring Modified Combretastatin Analogues: Syntheses and Antineoplastic Activity

Autor: Koji Ohsumi, Yumiko Fukuda, Ryusuke Nakagawa, Takashi Tsuji, Yukio Akiyama, Yukio Nihei, Koichi Fujita, Toshihiro Hatanaka, Yasuyo Suga

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c4af049e9046c13afb83380ce3ee7da
https://doi.org/10.1002/chin.199911290

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