Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Koji Nagao"'
Publikováno v:
Metabolites, Vol 14, Iss 4, p 201 (2024)
Betaine structural analogs are compounds characterized by the presence of positive and negative charges in a single molecule and have been reported to have physiological properties, such as anti-inflammatory activities. In this study, we performed a
Externí odkaz:
https://doaj.org/article/ff5a50e6f9ae45cd8ee3a73fb671854f
Autor:
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The levels of catalytic subunit of the RNaseH2 enzyme, RNAseH2A, decrease during senescence promoting nucleotide accumulation and a senescence-associated secretory phenotype.
Externí odkaz:
https://doaj.org/article/c3317a7c0604439689709bd59c372b06
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/1d19f7e110e14db89501d7317f734186
Autor:
Shin-Ya Isobe, Shin-ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D. Donaldson, Chikashi Obuse
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109383- (2021)
Summary: DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded
Externí odkaz:
https://doaj.org/article/4755f742828b4ed48e35afdcc3b31afd
Publikováno v:
Molecules, Vol 27, Iss 9, p 2640 (2022)
Edible algae Neopyropia yezoensis is used as “Nori”, its dried sheet product, in Japanese cuisine. Its lipid components reportedly improve hepatic steatosis in obese db/db mice. In this study, we prepared “Nori powder (NP)” and “fermented N
Externí odkaz:
https://doaj.org/article/1316699277954432a2f1b9c2396da03d
Publikováno v:
Metabolites, Vol 12, Iss 1, p 26 (2021)
Dietary sterols are catabolized into various substances in the intestinal tract. Dietary 3-oxo derivatives of cholesterol and plant sterols (e.g., cholest-4-en-3-one and campest-5-en-3-one) have been shown to have anti-obesity effects. In this study,
Externí odkaz:
https://doaj.org/article/d2324a1cf6c046aba9258b35a5ec0639
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 297-307 (2017)
DNA double-strand breaks (DSBs) are repaired by either the homology-directed repair (HDR) or the non-homologous end-joining (NHEJ) pathway. RIF1 (RAP1-interacting factor homolog) was recently shown to stimulate NHEJ through an interaction with 53BP1
Externí odkaz:
https://doaj.org/article/7015b6ffe76a4a358bb5a8168ccc6603
Autor:
Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T Kanemaki, Chikashi Obuse, Eiji Hara
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in e
Externí odkaz:
https://doaj.org/article/e3766fd98b5947d28ef1846c81904cc6
Autor:
Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to DNA methylation sites. However, the involvement of deubiquitylating enzymes (DUBs)
Externí odkaz:
https://doaj.org/article/08433a10a663408cb2881ea8919a7717
Autor:
Haruhiko Asakawa, Tomoko Kojidani, Hui-Ju Yang, Chizuru Ohtsuki, Hiroko Osakada, Atsushi Matsuda, Masaaki Iwamoto, Yuji Chikashige, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008061 (2019)
The nuclear pore complex (NPC) forms a gateway for nucleocytoplasmic transport. The outer ring protein complex of the NPC (the Nup107-160 subcomplex in humans) is a key component for building the NPC. Nup107-160 subcomplexes are believed to be symmet
Externí odkaz:
https://doaj.org/article/15cba3af964a4a68b0c650ec4ed36c2c