Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Koji NISHI"'
Autor:
Kindness Lomotey Commey, Airi Enaka, Ryota Nakamura, Asami Yamamoto, Kenji Tsukigawa, Koji Nishi, Masaki Otagiri, Keishi Yamasaki
Publikováno v:
Toxins, Vol 16, Iss 7, p 316 (2024)
The characteristic accumulation of circulating uremic toxins, such as indoxyl sulfate (IS), in chronic kidney disease (CKD) further exacerbates the disease progression. The gut microbiota, particularly gut bacterial-specific enzymes, represents a sel
Externí odkaz:
https://doaj.org/article/b847bccec066409f99b9381cd3db9e67
Autor:
Kindness L. Commey, Airi Enaka, Ryota Nakamura, Asami Yamamoto, Kenji Tsukigawa, Koji Nishi, Daisuke Iohara, Fumitoshi Hirayama, Masaki Otagiri, Keishi Yamasaki
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 82 (2024)
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs)
Externí odkaz:
https://doaj.org/article/339c5314131e47499ce83800b725a500
Autor:
Akito Kawai, Yoshihiro Kobashigawa, Kenshiro Hirata, Hiroshi Morioka, Shuhei Imoto, Koji Nishi, Victor Tuan Giam Chuang, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
ACS Omega, Vol 7, Iss 34, Pp 29944-29951 (2022)
Externí odkaz:
https://doaj.org/article/2ad5220966ff41829eaa98be47046a04
Autor:
Kindness L. Commey, Akari Nakatake, Airi Enaka, Ryota Nakamura, Koji Nishi, Kenji Tsukigawa, Hirohito Ikeda, Koki Yamaguchi, Daisuke Iohara, Fumitoshi Hirayama, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15091 (2023)
4-phenylbutyrate (PB) and structurally related compounds hold promise for treating many diseases, including cancers. However, pharmaceutical limitations, such as an unpleasant taste or poor aqueous solubility, impede their evaluation and clinical use
Externí odkaz:
https://doaj.org/article/2859208fb89746b3823f4ef019660ac5
Autor:
Kenshiro Hirata, Akito Kawai, Victor Tuan Giam Chuang, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4413-4419 (2022)
Externí odkaz:
https://doaj.org/article/f99ee7371bde438d8a3267907352f9af
Autor:
Satoshi Gondaira, Koji Nishi, Jumpei Fujiki, Hidetomo Iwano, Reina Watanabe, Ayako Eguchi, Yuki Hirano, Hidetoshi Higuchi, Hajime Nagahata
Publikováno v:
Veterinary Research, Vol 52, Iss 1, Pp 1-11 (2021)
Abstract Mycoplasma bovis (M. bovis) is a significant worldwide pathogen of cattle. Neutrophils have an important role in the innate immune response during infection with M. bovis. However, even though neutrophils accumulate in M. bovis infection, th
Externí odkaz:
https://doaj.org/article/8ddcb3337aa141579beedb5632bd7079
Autor:
Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, Tuoping Luo, Lei Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the
Externí odkaz:
https://doaj.org/article/358be672ffd24c55bc5303397e78ae42
Publikováno v:
Biochemistry and Biophysics Reports, Vol 14, Iss C, Pp 155-160 (2018)
It is well known that various physiological factors such as pH, endogenous substances or post-translational modifications can affect the conformational state of human serum albumin (HSA). In a previous study, we reported that both pH- and long chain
Externí odkaz:
https://doaj.org/article/74794110fec0470899bbbb0dd6cbf49b
Autor:
Kenshiro Hirata, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Tuan Giam Chuang, Yuji Uchida, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
Toxins, Vol 13, Iss 11, p 811 (2021)
The binding of drugs to plasma protein is frequently altered in certain types of renal diseases. We recently reported on the effects of oxidation and uremic toxins on the binding of aripiprazole (ARP) to human serum albumin. In our continuing investi
Externí odkaz:
https://doaj.org/article/5521bd7ff6104aa1a466933dd37f6b68
Autor:
Kenji Tsukigawa, Shuhei Imoto, Keishi Yamasaki, Koji Nishi, Toshihiko Tsutsumi, Shoko Yokoyama, Yu Ishima, Masaki Otagiri
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 22 (2020)
In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable,
Externí odkaz:
https://doaj.org/article/c199fb612efc4135a939a495c239d2ad