Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Koji Kakihata"'
Autor:
Yutaka Ariyoshi, Koji Kakihata, Jun-ichi Tadokoro, Shuji Masatani, Masahiro Fukuoka, Yuh Sakata, Tomoo Shiozawa, Minoru Shimazaki, Fumie Yamaguchi
Publikováno v:
Japanese Journal of Clinical Oncology. 41:1101-1111
Objective: The actual condition of drug utilization and the adverse drug reactions profile of irinotecan hydrochloride hydrate (irinotecan), an antitumor drug, were examined on the basis of all the case survey results from April 1995 to January 2000.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cdf857410e41369936df02dd07d704
https://doi.org/10.1093/jjco/hyr105
https://doi.org/10.1093/jjco/hyr105
Publikováno v:
The Journal of Toxicological Sciences. 23:561-574
Thirteen-week oral repeated dose toxicity of ecabapide, a gastroprokinetic drug, was investigated in dogs at dosage levels of 50, 175 or 600 mg/kg, and in rats at dosage levels of 25, 100, 400 or 1600 mg/kg. In dogs, vomiting, aqueous salivation, bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23311b8292b4bfb33905f6b2c4775beb
https://doi.org/10.2131/jts.23.supplementiii_561
https://doi.org/10.2131/jts.23.supplementiii_561
Autor:
Koji Fujino, Satoshi Morita, Akihiko Gemma, Jun-ichi Tadokoro, Narikazu Boku, Toshitaka Fujiki, Tomoo Shiozawa, Shuji Masatani, Koji Kakihata
Publikováno v:
Japanese Journal of Clinical Oncology
Objectives This analysis was conducted to clarify risk factors for severe adverse effects and treatment-related deaths reported during a postmarketing survey of irinotecan. Methods The survey covered all patients treated with irinotecan in Japan betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903e5d233910054fe52064b66316a09f
https://pubmed.ncbi.nlm.nih.gov/23536639
https://pubmed.ncbi.nlm.nih.gov/23536639
Autor:
Hisashi Yamamura, Kazuhisa Furuhama, Nami Ishijima, Hiroshi Ohno, Yuri Genda, Yuji Takahashi, Koji Kakihata, Mamoru Nomura
Publikováno v:
The Journal of Toxicological Sciences. 20:47-66
The single-dose intravenous toxicities of iodixanol, a new nonionic iso-osmolar contrast medium, were investigated in mice, rats and monkeys. The LD50 values were estimated to be 17.9 gI/kg for male mice and 16.2 gI/kg for female mice, 18.8 gI/kg for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40080a32883f73f2f7ea39f729a491d
https://doi.org/10.2131/jts.20.supplementi_47
https://doi.org/10.2131/jts.20.supplementi_47
Autor:
Mamoru Nomura, Shigeo Harada, Koji Kakihata, Satoshi Takayama, Makoto Shimada, Kunio Matsuhashi, Yukari Sakaguchi
Publikováno v:
The Journal of Toxicological Sciences. 20:309-317
Sprague-Dawley male rats were administered nefiracetam orally at daily doses of 500 and 1500 mg/kg/day for 4 or 9 weeks. Although the copulation index was not affected by nefiracetam treatment, the fertility index was extremely low in the 1500 mg/kg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9296c969d31b4bb5a2686a47be8972cc
https://doi.org/10.2131/jts.20.309
https://doi.org/10.2131/jts.20.309
Autor:
Tadamichi Suzuki, Noritoshi Yoshii, Masaki Nagashima, Akihiko Gemma, Koji Kakihata, Akira Kon
Publikováno v:
Anti-cancer drugs. 22(6)
Irinotecan-induced interstitial lung disease (ILD) requires accurate diagnosis, followed by prompt and appropriate treatment. This study was conducted to compile information and imaging data to define the characteristics of irinotecan-induced ILD. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e724278405a4ba3a61024ed1604f22e
https://pubmed.ncbi.nlm.nih.gov/21562406
https://pubmed.ncbi.nlm.nih.gov/21562406
Publikováno v:
Fundamental and Applied Toxicology. 20:141-146
Heinz Body Hemolytic Anemia Induced by DQ-2511, a New Anti-ulcer Drug, in Dogs. Ohno, H., Tojo, H., Kakihata, K., Nomura, M., and Takayama, S. (1993). Fundam. Appl. Toxicol. 20, 141-146. DQ-2511, a new anti-ulcer drug, was administered to beagle dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb02fd369d9649f22709ea190ca4d3d
https://doi.org/10.1006/faat.1993.1019
https://doi.org/10.1006/faat.1993.1019
Autor:
Kaichiro, Yamamoto, Michio, Iwahana, Eiji, Kumazawa, Koji, Kakihata, Kunio, Abe, Fuyumi, Hirano, Akiko, Tohgo, Hiroshi, Hoshiai, Kiichiro, Noda
Publikováno v:
Oncology reports. 10(3)
Antitumor activity of combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin was compared to that with CPT-11 and cisplatin. In vitro cytotoxicity of SN-38 (an active metabolite of CPT-11) in combination with nedaplatin or cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b03b2f15975bc82efc3a309c3e591e0
https://pubmed.ncbi.nlm.nih.gov/12684629
https://pubmed.ncbi.nlm.nih.gov/12684629
Publikováno v:
Blood & Vessel. 11:179-185
A polyethylene tubing was installed between the right carotid artery and the jugular vein of the rat to make a loop-shaped arterio-venous shunt. In most of the rats, the vascular shunt was obstructed by white thrombi together with blood clot within 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0bfaf73ba32f4c10580f49d7579bcc0
https://doi.org/10.2491/jjsth1970.11.179
https://doi.org/10.2491/jjsth1970.11.179
Publikováno v:
Thrombosis research. 12(6)
Anti-thrombotic action of Ticlopidine, 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-C]pyridine hydrochloride, was studied by using a lactic acidosis-induced pulmonary thrombosis model in rats. Ticlopidine was highly effective in preventing thrombu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfc46ca88b90de3756771fb5952b285
https://pubmed.ncbi.nlm.nih.gov/694822
https://pubmed.ncbi.nlm.nih.gov/694822