Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Koji Hase"'
Autor:
Neil A. Mabbott, Koji Hase
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/017f85d2374c43aca733b51bc29c55cc
Autor:
Yusuke Kinashi, Keisuke Tanaka, Shunsuke Kimura, Masato Hirota, Seiga Komiyama, Tomoko Shindo, Akinori Hashiguchi, Daisuke Takahashi, Shinsuke Shibata, Shin-Ichiro Karaki, Hiroshi Ohno, Koji Hase
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105256- (2024)
Summary: Background: Intestinal epithelial cells (IECs) serve as robust barriers against potentially hostile luminal antigens and commensal microbiota. Epithelial barrier dysfunction enhances intestinal permeability, leading to leaky gut syndrome (LG
Externí odkaz:
https://doaj.org/article/8ccf4f716dee42168b9fba259ad46b8a
Autor:
Motoyoshi Nagai, Takuma Okawa, Kazuaki Nakata, Daisuke Takahashi, Reina Miyajima, Hiroaki Shiratori, Daisuke Yamanaka, Atsuo Nakamura, Chinatsu Oyama, Shin-Ichiro Takahashi, Noriko Toyama-Sorimachi, Koichiro Suzuki, Wakana Ohashi, Taeko Dohi, Yuki I. Kawamura, Koji Hase
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114490- (2024)
Summary: Although oral tolerance is a critical system in regulating allergic disorders, the mechanisms by which dietary factors regulate the induction and maintenance of oral tolerance remain unclear. To address this, we explored the differentiation
Externí odkaz:
https://doaj.org/article/55b12c9964a04ec7ade407251c127f30
Autor:
Hiroaki Shiratori, Hiroyuki Oguchi, Yosuke Isobe, Kyu-Ho Han, Akira Sen, Kyosuke Yakebe, Daisuke Takahashi, Michihiro Fukushima, Makoto Arita, Koji Hase
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Commensal bacteria-derived metabolites are critical in regulating the host immune system. Although the impact of gut microbiota-derived hydrophilic metabolites, such as short-chain fatty acids, on immune cell functions and development has be
Externí odkaz:
https://doaj.org/article/85741347bd59403a969ba6cc230932e8
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Iodine-containing formulations have been widely used to treat iodine deficiency and as antiseptics. Lecithin-bound iodine (LBI) has been approved to treat allergic diseases in Japan; however, its underlying mechanism remains unknown. In this
Externí odkaz:
https://doaj.org/article/75cad2e71dff494dbe216b44cb6a3716
Autor:
Kisara Hattori-Muroi, Hanako Naganawa-Asaoka, Yuma Kabumoto, Kei Tsukamoto, Yosuke Fujisaki, Yumiko Fujimura, Seiga Komiyama, Yusuke Kinashi, Miki Kato, Shintaro Sato, Daisuke Takahashi, Koji Hase
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Peyer’s patches (PPs) are specialized gut-associated lymphoid tissues that initiate follicular helper T (Tfh)-mediated immunoglobulin A (IgA) response to luminal antigens derived from commensal symbionts, pathobionts, and dietary sources. IgA-produ
Externí odkaz:
https://doaj.org/article/1c11f392771d4f18985ffebdf94bdbfe
Autor:
Ryuji Ohue-Kitano, Hazuki Nonaka, Akari Nishida, Yuki Masujima, Daisuke Takahashi, Takako Ikeda, Akiharu Uwamizu, Miyako Tanaka, Motoyuki Kohjima, Miki Igarashi, Hironori Katoh, Tomohiro Tanaka, Asuka Inoue, Takayoshi Suganami, Koji Hase, Yoshihiro Ogawa, Junken Aoki, Ikuo Kimura
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Medium-chain triglycerides (MCTs), which consist of medium-chain fatty acids (MCFAs), are unique forms of dietary fat with various health benefits. G protein–coupled 84 (GPR84) acts as a receptor for MCFAs (especially C10:0 and C12:0); however, GPR
Externí odkaz:
https://doaj.org/article/ecafa7ca37954e389e6d0e6f51ad1a89
Autor:
Ryo Aoki, Masayoshi Onuki, Koya Hattori, Masato Ito, Takahiro Yamada, Kohei Kamikado, Yun-Gi Kim, Nobuhiro Nakamoto, Ikuo Kimura, Julie M. Clarke, Takanori Kanai, Koji Hase
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in the gut microbiome have been implicated in the development of NAFL
Externí odkaz:
https://doaj.org/article/e4bd897f0a5a498bbc7dc919d7381d93
Autor:
Narumi Ishihara, Yutaka Nakamura, Kyosuke Yakabe, Seiga Komiyama, Yumiko Fujimura, Tsuneyasu Kaisho, Shunsuke Kimura, Koji Hase
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Food allergy is a type I allergic reaction induced by mast cells and is mainly activated by allergen-specific immunoglobulin (Ig)E. Spi-B is an E26-transformation-specific (Ets) family transcription factor essential for the differentiation and functi
Externí odkaz:
https://doaj.org/article/53b2f1b39ea94fc8a85cc97a3437b6fd
Autor:
Seiga Komiyama, Takahiro Yamada, Nobuyuki Takemura, Norihiro Kokudo, Koji Hase, Yuki I. Kawamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Liver cancer is the fourth leading cause of cancer-related death. Hepatocellular carcinoma (HCC) is a primary liver cancer that results from chronic hepatitis caused by multiple predisposing factors such as viral infection, alcohol consumpti
Externí odkaz:
https://doaj.org/article/2228e235924542448d0773e953da3928