Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Koji, Itahana"'
Autor:
Javier Yu Peng Koh, Yoko Itahana, Alexander Krah, Habib Mostafa, Mingmin Ong, Sahana Iwamura, Dona Mariya Vincent, Sabhashina Radha Krishnan, Weiying Ye, Pierre Wing Chi Yim, Tushar M. Khopade, Kunihiko Chen, Pui San Kong, Lin-Fa Wang, Roderick W. Bates, Yasuhisa Kimura, Rajesh Viswanathan, Peter J. Bond, Koji Itahana
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibi
Externí odkaz:
https://doaj.org/article/a204bbaa5a074bcea4992233927d498b
Autor:
N Suhas Jagannathan, Javier Yu Peng Koh, Younghwan Lee, Radoslaw Mikolaj Sobota, Aaron T Irving, Lin-fa Wang, Yoko Itahana, Koji Itahana, Lisa Tucker-Kellogg
Publikováno v:
eLife, Vol 13 (2024)
Bats have unique characteristics compared to other mammals, including increased longevity and higher resistance to cancer and infectious disease. While previous studies have analyzed the metabolic requirements for flight, it is still unclear how bat
Externí odkaz:
https://doaj.org/article/7ab045543ac841e5b6c2b6512e26abdd
Autor:
Jagannathan, N. Suhas, Yu Peng Koh, Javier, Younghwan Lee, Sobota, Radoslaw Mikolaj, Irving, Aaron T., Lin-fa Wang, Yoko Itahana, Koji Itahana, Tucker-Kellogg, Lisa
Publikováno v:
eLife; 7/22/2024, p1-31, 31p
Autor:
Javier Koh, Yoko Itahana, Ian H. Mendenhall, Dolyce Low, Eunice Xin Yi Soh, Alvin Kunyao Guo, Yok Teng Chionh, Lin-Fa Wang, Koji Itahana
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the AB
Externí odkaz:
https://doaj.org/article/5e6e7ed316d54035a1bd7923fee4f815
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Obesity is increasing in prevalence and has become a global public health problem. The main cause of obesity is a perturbation in energy homeostasis, whereby energy intake exceeds energy expenditure. Although mitochondrial dysfunction has be
Externí odkaz:
https://doaj.org/article/a5a94b07e7564e258279b3d0426682af
Autor:
N. Suhas Jagannathan, Javier Yu Peng Koh, Younghwan Lee, Radoslaw M Sobota, Aaron Irving, Lin-Fa Wang, Yoko Itahana, Koji Itahana, Lisa Tucker-Kellogg
Bats have unique characteristics compared to other mammals, including increased longevity and higher resistance to cancer and infectious disease. While previous studies have analyzed the metabolic requirements for flight, it is still unclear how bat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521fff94c4817bd7dfcaddb81b40814e
https://doi.org/10.1101/2023.05.08.537600
https://doi.org/10.1101/2023.05.08.537600
Autor:
Patrick Tan, Koji Itahana, Boon Huat Bay, Puay Hoon Tan, Qiang Yu, Pieter Mathijs Voorhoeve, Steve Rozen, Anuradha Pandey, Aye Aye Thike, Shen Li Zhang, Yingnan Yu, Yonghui Wu, Na-Yu Chia, Zheng Deng Lei, Yoko Itahana, Lai Ling Cheng
PDF file - 484K, Table S1. Clinical Characteristics of the GC Cohort Analyzed in this Study. Table S2. Differentially-Regulated Genes in DZNep-Sensitive and Resistant Lines after DZNep Treatment. Table S3. Genomic Status of TP53 in Gastric Cancer Cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5fb2fe62c86e2682f5a2baa9a556e0
https://doi.org/10.1158/1078-0432.22445472
https://doi.org/10.1158/1078-0432.22445472
Autor:
Patrick Tan, Koji Itahana, Boon Huat Bay, Puay Hoon Tan, Qiang Yu, Pieter Mathijs Voorhoeve, Steve Rozen, Anuradha Pandey, Aye Aye Thike, Shen Li Zhang, Yingnan Yu, Yonghui Wu, Na-Yu Chia, Zheng Deng Lei, Yoko Itahana, Lai Ling Cheng
Purpose: DZNep (3-deazaneplanocin A) depletes EZH2, a critical component of polycomb repressive complex 2 (PRC2), which is frequently deregulated in cancer. Despite exhibiting promising anticancer activity, the specific genetic determinants underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d379e440c52982e0e6f8d9cb08b5b141
https://doi.org/10.1158/1078-0432.c.6520488
https://doi.org/10.1158/1078-0432.c.6520488
Publikováno v:
Journal of Cell Science. 135
Accelerated aerobic glycolysis is a distinctive metabolic property of cancer cells that confers dependency on glucose for survival. However, the therapeutic strategies targeting this vulnerability are still inefficient and have unacceptable side effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf1e4d5ce3b057bd7dd07410102d492
https://doi.org/10.1242/jcs.259090
https://doi.org/10.1242/jcs.259090
Autor:
Shi Yun Yeo, Yoko Itahana, Alvin Kunyao Guo, Rachel Han, Kozue Iwamoto, Hung Thanh Nguyen, Yi Bao, Kai Kleiber, Ya Jun Wu, Boon Huat Bay, Mathijs Voorhoeve, Koji Itahana
Publikováno v:
eLife, Vol 5 (2016)
Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling a
Externí odkaz:
https://doaj.org/article/81cca80787a441dfb2b58c6e42a290ba