Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Koit Aasumets"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101142- (2021)
The correct organization of mitochondrial DNA (mtDNA) in nucleoids and the contacts of mitochondria with the ER play an important role in maintaining the mitochondrial genome distribution within the cell. Mitochondria-associated ER membranes (MAMs) c
Externí odkaz:
https://doaj.org/article/39426409ccb144888c9438378921349f
Autor:
Aleksandr Ianevski, Evgeny Kulesskiy, Klara Krpina, Guofeng Lou, Yahyah Aman, Andrii Bugai, Koit Aasumets, Yevhen Akimov, Daria Bulanova, Kiira Gildemann, Albert F. Arutyunyan, Olga Yu. Susova, Alexei L. Zhuze, Ping Ji, Wei Wang, Toril Holien, Marit Bugge, Eva Zusinaite, Valentyn Oksenych, Hilde Lysvand, Joachim M. Gerhold, Magnar Bjørås, Pål Johansen, Anders Waage, Caroline A. Heckman, Evandro F. Fang, Denis E. Kainov
Publikováno v:
Cancers, Vol 12, Iss 6, p 1694 (2020)
Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that not only invasive RNA or DN
Externí odkaz:
https://doaj.org/article/60febeb3e4294dfcb8c798c07b5bc507
Autor:
Mara Doimo, Sanna Abrahamsson, Valentin L’Hôte, Mama Ndi, Rabindra Nath Das, Koit Aasumets, Andreas Berner, Steffi Goffart, Jaakko L.O. Pohjoismäki, Marcela Dávila López, Erik Chorell, Sjoerd Wanrooij
Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how stalled replication forks lead to mtDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bda214bb0abccd1297c56c02bdab69
https://doi.org/10.1101/2022.06.08.495283
https://doi.org/10.1101/2022.06.08.495283
Autor:
Alexei L. Zhuze, Valentyn Oksenych, Koit Aasumets, Klara Krpina, Evandro Fei Fang, Eva Zusinaite, Denis E. Kainov, Ping Ji, Yahyah Aman, Magnar Bjørås, Pål Johansen, Albert F. Arutyunyan, Marit Bugge, Wei Wang, Caroline A. Heckman, Guofeng Lou, Hilde Lysvand, Kiira Gildemann, Andrii Bugai, Joachim M. Gerhold, Toril Holien, Yevhen Akimov, Anders Waage, Aleksandr Ianevski, Evgeny Kulesskiy, Daria Bulanova, Olga Yu. Susova
Publikováno v:
Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1694, p 1694 (2020)
Volume 12
Issue 6
Cancers, Vol 12, Iss 1694, p 1694 (2020)
Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that not only invasive RNA or DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14f7d0a1503ffc60e1aa98b8b69c2de
http://hdl.handle.net/10852/82462
http://hdl.handle.net/10852/82462
Autor:
Joachim M. Gerhold, Koit Aasumets, Jaakko L. O. Pohjoismäki, Steffi Goffart, Yuliya Basikhina
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101142-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
The correct organization of mitochondrial DNA (mtDNA) in nucleoids and the contacts of mitochondria with the ER play an important role in maintaining the mitochondrial genome distribution within the cell. Mitochondria-associated ER membranes (MAMs) c
Autor:
Sabine Schneider, Sabine Schmitt, Barbara Conradt, Koit Aasumets, Kenji Schorpp, Annette Feuchtinger, Olga Hofmeister, Anita Wagner, Kamyar Hadian, Andreas Maiser, Stéphane G. Rolland, Alexander Wolf, Joachim M. Gerhold, Heinrich Leonhardt, Hans Zischka
Publikováno v:
J. Cell Sci. 132:jcs223891 (2019)
The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among others, demethy
Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2
Autor:
Mika Paloheinä, Joachim M. Gerhold, Anu Hangas, Jaakko L. O. Pohjoismäki, Steffi Goffart, Koit Aasumets, Nina J. Kekäläinen
Publikováno v:
Nucleic Acids Research
Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological forms, although their fu