Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Koichiro Ootsu"'
Autor:
Koichiro Ootsu, Takashi Houkan, Kazunori Gotoh, Koichi Yukishige, Katsuo Midoro, Kosaku Fujiwara
Publikováno v:
Japanese Journal of Cancer Research. 88:306-315
The antitumor activity of recombinant human interleukin 2 (rIL-2) in combination with 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR) against marine colon carcinoma 26 (Colon 26) was studied. BALB/c mice were treated daily for 15 days with 5'-DFUR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1063a8a76663059f42351275aadc5a8a
https://doi.org/10.1111/j.1349-7006.1997.tb00382.x
https://doi.org/10.1111/j.1349-7006.1997.tb00382.x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2189-2194
New water soluble camptothecin derivatives with excellent antitumor activity have been designed and synthesized. The synthetic approach includes an efficient route to 7-aminoethyl and 7-aminomethyl camptothecins using either N-Boc protected aminoprop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4fe59f82dbc43857e0d1732e36ac1e8
https://doi.org/10.1016/0960-894x(95)00354-v
https://doi.org/10.1016/0960-894x(95)00354-v
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:230-235
Either the alpha- or gamma-carboxyl group of the glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5- yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and its related compound (1a) was replaced with a 1H-tetrazole ring, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f856c9ce3a6bf7dc9515de96128304d3
https://doi.org/10.1248/cpb.43.230
https://doi.org/10.1248/cpb.43.230
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:256-261
Novel pyrrolo[2, 3-d]pyrimidine antifolates (1a, b and 2a, b) with a nitrogen atom in the bridge chain between the 2, 4-diaminopyrrolo[2, 3-d]pyrimidine and phenylene rings were designed and efficiently synthesized. These compounds exhibited more pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2479efbc2a9ecb3555bdb3d7bcd9a76e
https://doi.org/10.1248/cpb.43.256
https://doi.org/10.1248/cpb.43.256
Autor:
Naoru Hamaguchi, Hajime Toguchi, Susumu Iwasa, Kazunori Gotoh, Jun Sato, Kazuhiro Doken, Koichiro Ootsu, Yasuaki Ogawa
Publikováno v:
Biotherapy. 6:225-231
We have investigated biological properties of an immune complex of recombinant interleukin-2 (rIL-2) and a monoclonal antibody against rIL-2 in mice for induction of killer cells and for anti-tumor activity. We have also examined the clearance of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96c8ad0b62388e070f25e16dc3cfd89
https://doi.org/10.1007/bf01878084
https://doi.org/10.1007/bf01878084
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0576722e4304089f396e80535266e82e
https://doi.org/10.1002/chin.199535240
https://doi.org/10.1002/chin.199535240
Publikováno v:
ChemInform. 26
Novel pyrrolo[2, 3-d]pyrimidine antifolates (1a, b and 2a, b) with a nitrogen atom in the bridge chain between the 2, 4-diaminopyrrolo[2, 3-d]pyrimidine and phenylene rings were designed and efficiently synthesized. These compounds exhibited more pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de05ca4dd7dbaa8d91298338f30e1a9e
https://doi.org/10.1002/chin.199535189
https://doi.org/10.1002/chin.199535189
Publikováno v:
ChemInform. 27
New water soluble camptothecin derivatives with excellent antitumor activity have been designed and synthesized. The synthetic approach includes an efficient route to 7-aminoethyl and 7-aminomethyl camptothecins using either N-Boc protected aminoprop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb366691d5c05ca14aa7e04498c625ce
https://doi.org/10.1002/chin.199606243
https://doi.org/10.1002/chin.199606243
Autor:
Yoshio Yoshioka, Koichi Yukishige, Sei Yoshida, Megumi Wajima, Fumio Itoh, Koichiro Ootsu, H. Akimoto
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7685ef63eb1d6e95c866ee31445a08
https://doi.org/10.1002/chin.199711177
https://doi.org/10.1002/chin.199711177
Publikováno v:
ChemInform. 33
A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::065575641438207957e7bfa843079384
https://doi.org/10.1002/chin.200212270
https://doi.org/10.1002/chin.200212270