Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Koichiro Nishimura"'
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3367-3374
The content of monoclonal antibody (mAb) fragments in pharmaceutical mAb products is a critical quality attribute and should be controlled for safety. Peptide bonds in the hinge region of mAbs are susceptible to hydrolysis, generating Fc-Fab fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f413ec99de5b47a3ada175e34b3ef4a
https://doi.org/10.1016/j.xphs.2021.05.023
https://doi.org/10.1016/j.xphs.2021.05.023
Publikováno v:
Journal of pharmaceutical sciences. 111(12)
The presence of monoclonal antibody (mAb) fragments in pharmaceutical mAb products is a critical quality attribute and should be controlled for safety. Several mAb fragments derived from clip formation in the complementarity determining regions (CDRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8abd8028c0668796d53f49d216a2877
https://pubmed.ncbi.nlm.nih.gov/36007559
https://pubmed.ncbi.nlm.nih.gov/36007559
Autor:
Akira Okazaki, Kumi Yanagisawa, Jun Fukuda, Koichiro Nishimura, Yuki Yagi, Megumi Endo, Katsuyoshi Yamazaki
Publikováno v:
Analytical Sciences. 35:1333-1340
Human antithrombin (AT) has two isoforms of which the predominant α-form is glycosylated on all four possible glycosylation sites and the lower abundant β-isoform lacks the oligosaccharide on Asn135. The main oligosaccharide structure of human AT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687f5827f297afec8766c9e17284a029
https://doi.org/10.2116/analsci.19p181
https://doi.org/10.2116/analsci.19p181
Autor:
Koichiro Nishimura, Toshikazu Saitoh
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1043-1046
The 5-bromo-2-methylamino-8-methoxyquinazoline (1) is a key intermediate in our drug discoveries. Compound 1 bears a monomethylamino group at the 2-position of the quinazoline ring. This compound has been synthesized from 6-bromo-2-fluoro-3-methoxybe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92eff9022c2b445ce30dd442cec67693
https://doi.org/10.1248/cpb.c16-00187
https://doi.org/10.1248/cpb.c16-00187
Autor:
Kyoji Ando, Hiroshi Tsumuki, Koichiro Nishimura, Arata Yanagisawa, Taga Masashi, Shin-ichiro Mohri, Iwao Chujo, Tsuyoshi Taguchi, Toshiyuki Atsumi
Publikováno v:
Organic Process Research & Development. 15:376-381
A short and practical synthesis of the PDE4 inhibitor K-34 (1) was developed. This synthesis was achieved in four steps and with a 58% overall yield. The unique spiro acetal was created with except...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62ed2550db08f9ff9410176407d5f58
https://doi.org/10.1021/op100291g
https://doi.org/10.1021/op100291g
Autor:
Tetsuya Nezu, Shin-ichiro Mohri, Koichiro Nishimura, Wakako Tamaki, Sachiko Kato, Ayako Maki, Eiichiro Imai, Arata Yanagisawa, Kyoji Ando
Publikováno v:
Organic Process Research & Development. 14:1182-1187
A practical and scalable synthesis of a PDE4 inhibitor KW-4490 (1) was developed. This improved synthesis features the construction of the 1-arylcyclohexene (9) by the Diels−Alder reaction followed by a newly established Bronsted acid-promoted hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb4ed6f0107ab8ddb6503e23f5f2f6b
https://doi.org/10.1021/op1001287
https://doi.org/10.1021/op1001287
Publikováno v:
IEEJ Transactions on Industry Applications. 114:910-917
To realize the economical and high performance drive for urban transit, a linear motor is driven as a high performance expensive motor or a economical secondary sheet type linear induction motor (LIM) with relative poor performance which is in practi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67e2ec3f1bea328639eb5cd642c4e7d2
https://doi.org/10.1541/ieejias.114.910
https://doi.org/10.1541/ieejias.114.910
Publikováno v:
2008 Digest of Technical Papers - International Conference on Consumer Electronics.
A partial-response maximum-likelihood (PRML) decode system, which enables to read Blu-ray Disc (BD) and HD DVD, has been developed. This system integrates following two functions; a PRML decoder for BD/HD DVD readout at highspeed, and an improved ada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38265039aafc4ea5d9b1b10797349cc4
https://doi.org/10.1109/icce.2008.4588010
https://doi.org/10.1109/icce.2008.4588010
Publikováno v:
2003 IEEE International Conference on Consumer Electronics, 2003. ICCE..
High speed DVD-RAM and DVD-R recording technologies have been established for the DVD-multi drive system. The developed key components are LSIs, especially a laser diode driver, and an optical pickup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72d12ddee8d7334f9272ed9bdda0c78
https://doi.org/10.1109/icce.2003.1218952
https://doi.org/10.1109/icce.2003.1218952
Publikováno v:
International Symposium on Optical Memory and Optical Data Storage Topical Meeting.
Numerous types of DVD recording equipment have emerged on the market, and there is much demand for such optical storage systems with high speed and large capacity for digital high definition broadcasts. However, it becomes difficult to maintain data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79376362e1e71f4b82f5f5ae03889fbb
https://doi.org/10.1109/omods.2002.1028583
https://doi.org/10.1109/omods.2002.1028583