Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Koichiro Nakahara"'
Publikováno v:
Structures and Infrastructure Systems ISBN: 9781351182805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25431d1704e120fb68c1abab68012c9a
https://doi.org/10.1201/9781351182805-5
https://doi.org/10.1201/9781351182805-5
Autor:
Hitoshi Murai, Tamio Fujiwara, Makoto Kodama, Chiaki Wakasa-Morimoto, Mark R. Underwood, Shigeru Miki, Scott A. Foster, Toshio Fujishita, Edward P. Garvey, Brian A. Johns, Yoshihiro Matsushita, Masanori Kobayashi, Koichiro Nakahara, Akihiko Sato, Takeshi Endoh, Tomokazu Yoshinaga, Eiichi Oosugi, Takahiro Seki, Akemi Suyama, Shinobu Kawauchi
Publikováno v:
Antiviral Research. 80:213-222
Resistance passage studies were conducted with five INIs (integrase inhibitors) that have been tested in clinical trials to date: a new naphthyridinone-type INI S/GSK-364735, raltegravir, elvitegravir, L-870,810 and S-1360. In establishing the passag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed482ff8ae182b9facde2bb58c3491
https://doi.org/10.1016/j.antiviral.2008.06.012
https://doi.org/10.1016/j.antiviral.2008.06.012
Autor:
Ei'ichi Ami, Yoshio Hayashi, Koushi Hidaka, Nobuyuki Ohnishi, Yoshiaki Kiso, Yasuko Hori, Akinori Nagai, Shingo Nakatani, Yoshio Hamada, Akihiko Sato, Tooru Kimura, Koichiro Nakahara, Jeffrey-Tri Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 51:2992-3004
Several non-natural D-amino acid derivatives were introduced as P2/P3 residues in allophenylnorstatine-containing (Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) HIV protease inhibitors. The synthetic analogues exhibited potent inhibitory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f88df6798d758ab3b75b690673737
https://doi.org/10.1021/jm701555p
https://doi.org/10.1021/jm701555p
Autor:
Edward P. Garvey, Brian A. Johns, Margaret J. Gartland, Scott A. Foster, Wayne H. Miller, Robert G. Ferris, Richard J. Hazen, Mark R. Underwood, Eric E. Boros, James B. Thompson, Jason G. Weatherhead, Cecilia S. Koble, Scott H. Allen, Lee T. Schaller, Ronald G. Sherrill, Tomokazu Yoshinaga, Masanori Kobayashi, Chiaki Wakasa-Morimoto, Shigeru Miki, Koichiro Nakahara, Takeshi Noshi, Akihiko Sato, Tamio Fujiwara
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:901-908
The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration ± standard deviation, 8 ± 2 nM). As expected based on the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1ce24916536e22a701ee05912ccf1b
https://doi.org/10.1128/aac.01218-07
https://doi.org/10.1128/aac.01218-07
Autor:
Yoshiaki Kiso, Tooru Kimura, Shingo Nakatani, Koichiro Nakahara, Yoshio Hamada, Ei'ichi Ami, Akihiko Sato, Yoshio Hayashi, Koushi Hidaka, Jeffrey-Tri Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4213-4217
We designed several HIV protease inhibitors with various d-cysteine derivatives as P(2)/P(3) moieties based on the structure of clinical drug candidate, KNI-764. Herein, we report their synthesis, HIV protease inhibitory activity, HIV IIIB cell inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acccea548dcdc016691a2776eb0d8a0d
https://doi.org/10.1016/j.bmcl.2007.05.039
https://doi.org/10.1016/j.bmcl.2007.05.039
Autor:
Takahiro Seki, Erika Akihisa, Akemi Suyama-Kagitani, Mark R. Underwood, Shigeru Miki, Chiaki Wakasa-Morimoto, Tomokazu Yoshinaga, Masanori Kobayashi, Tamio Fujiwara, Koichiro Nakahara, Shinobu Kawauchi-Miki, Akihiko Sato
The recently approved HIV-1 integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) (S/GSK1349572) has overall advantageous activity when tested in vitro against HIV-1 with raltegravir (RAL) and elvitegravir (EVG) resistance signature mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98884bcc75fac06b3d410d516189f452
https://europepmc.org/articles/PMC4394817/
https://europepmc.org/articles/PMC4394817/
Publikováno v:
Structure and Infrastructure Engineering. 2:33-41
In order to establish a rational bridge management program, it is necessary to develop a cost-effective decision-support system for the maintenance of bridges. In this paper, an attempt is made to develop a bridge management system that can provide p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d50a669d2550f720e02588c9ed8013a2
https://doi.org/10.1080/15732470500031040
https://doi.org/10.1080/15732470500031040
Publikováno v:
Doboku Gakkai Ronbunshuu A. 62:656-668
本研究では，長期的視野で複数橋梁の維持管理計画を策定する事で，費用削減が可能である事を示し，遺伝的アルゴリズム(以下，GA)を用いて実用的な維持管理計画策定システムの構築を
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c916a0ed9b2c9f0ecf18705a17c2b3d
https://doi.org/10.2208/jsceja.62.656
https://doi.org/10.2208/jsceja.62.656
Autor:
Koichiro Nakahara, Tsuneaki Sakata
Publikováno v:
The Journal of Gene Medicine. 5:463-471
Background To enhance the antitumor efficacy of IL2 gene therapy, combinations of several other genes, such as p53, a tumor suppressor gene, or lymphotactin, a C-chemokine, and the IL2 gene are attempted, and synergistic effects are observed. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b4a8bbdbf1c8b5d163c0298fdc3f1e
https://doi.org/10.1002/jgm.369
https://doi.org/10.1002/jgm.369
Publikováno v:
Journal of applied mechanics. 6:1141-1148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08167d969298f77c84d75a097a4b1113
https://doi.org/10.2208/journalam.6.1141
https://doi.org/10.2208/journalam.6.1141