Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Koichiro Kodama"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4550-4553
The Pictet–Spengler reaction was applied to the N-terminal labeling of horse heart myoglobin. This was performed in the following two steps: (1) conversion of the N-terminal glycine residue to an α-keto aldehyde by a transamination reaction and (2
Autor:
Takashi Yabuki, Mikako Shirouzu, Seketsu Fukuzawa, Natsuko Matsuda, Kensaku Sakamoto, Koji Takio, Takanori Kigawa, Shigeyuki Yokoyama, Hiroshi Nakayama, Kazuo Tachibana, Koichiro Kodama
Publikováno v:
ChemBioChem. 8:232-238
A new carbon-carbon bond has been regioselectively introduced into a target position (position 32 or 174) of the Ras protein by two types of organopalladium reactions (Mizoroki-Heck and Sonogashira reactions). Reaction conditions were screened by usi
Autor:
Koichiro Kodama, Keiichi Konoki, Seketsu Fukuzawa, Shigeyuki Yokoyama, Kazuo Tachibana, Takuhiro Ito, Shun-ichi Sekine, Haruhiko Ehara, Marie Makino
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(10)
Okadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of protein serine/threonine phosphatases (PP) 1 and 2A, and the structural basis of phosphatase inhibition
Autor:
Hiroshi Nakayama, Koichiro Kodama, Takashi Yabuki, Natsuko Matsuda, Kensaku Sakamoto, Mikako Shirouzu, Takanori Kigawa, Seketsu Fukuzawa, Shigeyuki Yokoyama, Koji Takio, Kazuo Tachibana
Publikováno v:
ChemBioChem. 7:1577-1581
An Escherichia coli suppressor tRNA(Phe) (tRNA(Phe) (CUA)) was misacylated with 4-iodo-L-phenylalanine by using the A294G phenylalanyl-tRNA synthetase mutant (G294-PheRS) from E. coli at a high magnesium-ion concentration. The preacylated tRNA was ad
Autor:
Ichiro Hirao, Taeko Okuni, Tsuyoshi Fujiwara, Tomoko Yokogawa, Takashi Yokogawa, Tsuneo Mitsui, Takashi Yabuki, Shigeyuki Yokoyama, Kazuya Nishikawa, Takanori Kigawa, Takashi Ohtsuki, Koji Takio, Koichiro Kodama, Hiroshi Nakayama
Publikováno v:
Nature Biotechnology. 20:177-182
An unnatural base pair of 2-amino-6-(2-thienyl)purine (denoted by s) and pyridin-2-one (denoted by y) was developed to expand the genetic code. The ribonucleoside triphosphate of y was site-specifically incorporated into RNA, opposite s in a template
Publikováno v:
KAGAKU TO SEIBUTSU. 46:528-530
Autor:
Makoto Kitabatake, Koichiro Kodama, Takashi Yabuki, Koji Takio, Takanori Kigawa, Hiroshi Nakayama, Shigeyuki Yokoyama, Seketsu Fukuzawa, Kensaku Sakamoto
Publikováno v:
Journal of biochemistry. 148(2)
A variety of unique codons have been employed to expand the genetic code. The use of the opal (UGA) codon is promising, but insufficient information is available about the UGA suppression approach, which facilitates the incorporation of non-natural a
Autor:
Takanori, Kigawa, Emi, Yamaguchi-Nunokawa, Koichiro, Kodama, Takayoshi, Matsuda, Takashi, Yabuki, Natsuko, Matsuda, Ryuichiro, Ishitani, Osamu, Nureki, Shigeyuki, Yokoyama
Publikováno v:
Journal of structural and functional genomics. 2(1)
Multi-wavelength anomalous diffraction phasing is especially useful for high-throughput structure determinations. Selenomethionine substituted proteins are commonly used for this purpose. However, the cytotoxicity of selenomethionine drastically redu
Autor:
Koichiro Kodama, Natsuko Matsuda, Kensaku Sakamoto, Kazuo Tachibana, Koji Takio, Mikako Shirouzu, Seketsu Fukuzawa, Shigeyuki Yokoyama, Takanori Kigawa, Hiroshi Nakayama, Takashi Yabuki
Publikováno v:
ChemBioChem. 8:159-159
Palladium-catalyzed reactions have contributed to the advancement of many areas of organic chemistry, in particular, the synthesis of organic compounds such as natural products and polymeric materials. In this study, we have used a Mizoroki-Heck reac
Autor:
Koichiro Kodama, Natsuko Matsuda, Kensaku Sakamoto, Takanori Kigawa, Takashi Yabuki, Mikako Shirouzu, Seketsu Fukuzawa, Shigeyuki Yokoyama, Koji Takio, Kazuo Tachibana, Hiroshi Nakayama
Publikováno v:
ChemBioChem. 7:1-1