Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Koichiro Irie"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract We aimed to investigate the relationship between the risk of oral frailty and awareness of oral frailty among Japanese adults in an adult dental health field study conducted in Kanagawa Prefecture. Questionnaire data from a total of 5051 ind
Externí odkaz:
https://doaj.org/article/0a412e1c61f649c1822dc7b73b581fa9
Publikováno v:
Dentistry Journal, Vol 11, Iss 8, p 194 (2023)
Oral microbiota play a pivotal role in maintaining homeostasis, safeguarding the oral cavity, and preventing the onset of disease. Oral dysbiosis has the potential to trigger pro-inflammatory effects and immune dysregulation, which can have a negativ
Externí odkaz:
https://doaj.org/article/2af3eaa0f4b7491698576fd5bab62d9a
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The evolution of humans brought about a co-occurring evolution of the human brain, which is far larger and more complex than that of many other organisms. The brain has evolved characteristically in humans in many respects, including macro-and micro-
Externí odkaz:
https://doaj.org/article/67982d9d295045cd827d27efd080b38f
Autor:
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109124- (2021)
Summary: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a spe
Externí odkaz:
https://doaj.org/article/0fed81b11b5247d3a98746060e307b29
Autor:
Koichiro Irie
Publikováno v:
Journal of Epidemiology, Vol 27, Iss 2, Pp 69-74 (2017)
Background: Development of periodontal disease (PD) may be affected by socioeconomic status. This study examined the relationship between occupational status and PD in a 5-year prospective cohort of Japanese workers. Methods: In total, 19,633 partic
Externí odkaz:
https://doaj.org/article/0226264814cf435c86195418a7fc2d50
Autor:
Tetsuji Azuma, Koichiro Irie, Kazutoshi Watanabe, Fumiko Deguchi, Takao Kojima, Akihiro Obora, Takaaki Tomofuji
Publikováno v:
International Journal of Dentistry, Vol 2019 (2019)
An association between physical illness and sleep has been suggested. Disordered chewing might be a physical factor that is associated with sleep issues. This cross-sectional study aimed to determine whether chewing problems are associated with sleep
Externí odkaz:
https://doaj.org/article/6d9fb96453714064a6ba9ca203690fb2
Autor:
Keita Tsujimura, Koichiro Irie, Hideyuki Nakashima, Yoshihiro Egashira, Yoichiro Fukao, Masayuki Fujiwara, Masayuki Itoh, Masahiro Uesaka, Takuya Imamura, Yasukazu Nakahata, Yui Yamashita, Takaya Abe, Shigeo Takamori, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1887-1901 (2015)
Rett syndrome (RTT) is a neurodevelopmental disorder caused by MECP2 mutations. Although emerging evidence suggests that MeCP2 deficiency is associated with dysregulation of mechanistic target of rapamycin (mTOR), which functions as a hub for various
Externí odkaz:
https://doaj.org/article/686c56aae0c14514844775a62c0f01ca
Autor:
Yoko Uchida, Koichiro Irie, Daiki Fukuhara, Kota Kataoka, Takako Hattori, Mitsuaki Ono, Daisuke Ekuni, Satoshi Kubota, Manabu Morita
Publikováno v:
Molecules, Vol 23, Iss 7, p 1517 (2018)
Recent studies suggest that the commensal microbiota affects not only host energy metabolism and development of immunity but also bone remodeling by positive regulation of osteoclast activity. However, the mechanism of regulation of bone cells by the
Externí odkaz:
https://doaj.org/article/49d59bbc80f7425e9b188bc151965493
Autor:
Takaaki Tomofuji, Koichiro Irie, Toshihiro Sanbe, Tetsuji Azuma, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Manabu Morita
Publikováno v:
Japanese Dental Science Review, Vol 45, Iss 1, Pp 46-51 (2009)
Reactive oxygen species (ROS) are products of normal cellular metabolism. However, excessive production of ROS oxidizes DNA, lipids and proteins, inducing tissue damage. Studies have shown that periodontitis induces excessive ROS production in period
Externí odkaz:
https://doaj.org/article/93d7512c52914eafa235783dce0a0371
VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome.
Autor:
Weixiang Guo, Keita Tsujimura, Maky Otsuka I, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100215 (2014)
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disord
Externí odkaz:
https://doaj.org/article/f5c2536904d84b9a826d98f080248c89