Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Koichiro Haruwaka"'
Autor:
Kana Ozaki, Daisuke Kato, Ako Ikegami, Akari Hashimoto, Shouta Sugio, Zhongtian Guo, Midori Shibushita, Tsuyako Tatematsu, Koichiro Haruwaka, Andrew J. Moorhouse, Hideto Yamada, Hiroaki Wake
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA)
Externí odkaz:
https://doaj.org/article/979f3c83c7a34bd2aeab127d90ed220a
Autor:
Koichiro Haruwaka, Ako Ikegami, Yoshihisa Tachibana, Nobuhiko Ohno, Hiroyuki Konishi, Akari Hashimoto, Mami Matsumoto, Daisuke Kato, Riho Ono, Hiroshi Kiyama, Andrew J. Moorhouse, Junichi Nabekura, Hiroaki Wake
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although it is known that microglia respond to injury and systemic disease in the brain, it is unclear if they modulate blood–brain barrier (BBB) integrity, which is critical for regulating neuroinflammatory responses. Here authors demonstrate that
Externí odkaz:
https://doaj.org/article/e5cc6bbdb30641829f5b58b0a8df2eaf
Autor:
Ukpong B. Eyo, Koichiro Haruwaka, Mingshu Mo, Antony Brayan Campos-Salazar, Lingxiao Wang, Xenophon S. Speros, IV, Sruchika Sabu, Pingyi Xu, Long-Jun Wu
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109080- (2021)
Summary: Although an imbalance between neuronal excitation and inhibition underlies seizures, clinical approaches that target these mechanisms are insufficient in containing seizures in patients with epilepsy, raising the need for alternative approac
Externí odkaz:
https://doaj.org/article/6a81ac030e704f67b3ee479bc6230a3b
Autor:
Koichiro Haruwaka, Yanlu Ying, Yue Liang, Anthony D. Umpierre, Min-Hee Yi, Vaclav Kremen, Tingjun Chen, Tao Xie, Hailong Dong, Gregory A. Worrell, Long-Jun Wu
Microglia are resident immune cells of the central nervous system (CNS) and play key roles in brain homeostasis. During anesthesia, microglia increase their dynamic process surveillance and interact more closely with neurons. However, the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30fe41a6f684339aef0a69df540b1e31
https://doi.org/10.1101/2022.11.08.515728
https://doi.org/10.1101/2022.11.08.515728
Autor:
Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A. Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C. Ikezu, Zonghua Li, Axel D. Meneses, Yunjung Jin, Joshua A. Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L. Smith, Manling Xie, Yong U. Liu, Anthony D. Umpierre, Koichiro Haruwaka, Zachary S. Quicksall, Peter Storz, Yan W. Asmann, Long-Jun Wu, Guojun Bu
Publikováno v:
Journal of Experimental Medicine. 219
TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer’s disease (AD). As microglial responses modulated by TREM2 are central to AD pathogenesis, enhancing TREM2 signaling has been explored as an A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff47cd46285efea4757fe778fe1d7ac
https://doi.org/10.1084/jem.20212479
https://doi.org/10.1084/jem.20212479
Publikováno v:
Neurosci Bull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cbb9ef5b0f47cd3070f6969f5414c6
https://doi.org/10.1007/s12264-022-00846-5
https://doi.org/10.1007/s12264-022-00846-5
Autor:
Zhongtian Guo, Shouta Sugio, Hideto Yamada, Ako Ikegami, Akari Hashimoto, Kana Ozaki, Tsuyako Tatematsu, Midori Shibushita, Daisuke Kato, Andrew J. Moorhouse, Hiroaki Wake, Koichiro Haruwaka
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40
https://doi.org/10.1038/s41598-020-78294-2
https://doi.org/10.1038/s41598-020-78294-2
Publikováno v:
Neuropathology.
Microglia, the sole immune cells in the brain, are the key player for synaptic regulation required for our brain function in both developing and adult brain. They have highly motile processes to detect synaptic functions. Recent accumulated studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee678824f30ba1650b9984cedb09b9e
https://doi.org/10.1111/neup.12560
https://doi.org/10.1111/neup.12560
Publikováno v:
Neuropathology : official journal of the Japanese Society of Neuropathology. 39(3)
Microglia, the sole immune cells in the brain, are the key player for synaptic regulation required for our brain function in both developing and adult brain. They have highly motile processes to detect synaptic functions. Recent accumulated studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6843c82c726dfb28306cae817cf030c
https://pubmed.ncbi.nlm.nih.gov/31131941
https://pubmed.ncbi.nlm.nih.gov/31131941
Autor:
Sruchika Sabu, Ukpong B. Eyo, Mingshu Mo, Long Jun Wu, Koichiro Haruwaka, Lingxiao Wang, Antony Brayan Campos-Salazar, Pingyi Xu, Xenophon S. Speros
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 5, Pp 109080-(2021)
Cell Reports, Vol 35, Iss 5, Pp 109080-(2021)
SUMMARY Although an imbalance between neuronal excitation and inhibition underlies seizures, clinical approaches that target these mechanisms are insufficient in containing seizures in patients with epilepsy, raising the need for alternative approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21b4fac36fb9758de44fa5b30624f0c
http://europepmc.org/articles/PMC8164475
http://europepmc.org/articles/PMC8164475