Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Koichi Yasumura"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1721-1724
For the purpose of developing new antiseptics, we searched for compounds having high biocidal activity covering both gram-positive and gram-negative bacteria. Accordingly, we designed 1,5-disubstituted biguanides and synthesized them using two altern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7ea7b68fd2bb261f1754fd3f930db1
https://doi.org/10.1016/s0960-894x(97)00297-7
https://doi.org/10.1016/s0960-894x(97)00297-7
Autor:
Shintaro Ishikawa, Katsuyuki Yanagisawa, Koichi Yasumura, Zenji Makita, Wataru Fujii, Sakurako Nakamura, Tetsuya Kawata, Takao Koike
Publikováno v:
Diabetes. 46:895-899
Levels of tissue advanced glycation end products (AGEs) that result from nonenzymatic reactions of glucose and proteins are high in both diabetic and aging people. Irreversible AGE formation is based on increases in AGE-derived protein-to-protein cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1831eed4d1685222b9079aca15441b6c
https://doi.org/10.2337/diab.46.5.895
https://doi.org/10.2337/diab.46.5.895
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:963-966
Cephalosporins with catechol-containing (pyridinium-4′-thio)methyl groups at C-3 have been synthesized and examined their antibacterial activity. They were found to have high potency against gram-negative bacteria including Pseudomonas aeruginosa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaf5324eea64a6453928b4c9fa96bb41
https://doi.org/10.1016/0960-894x(95)00143-h
https://doi.org/10.1016/0960-894x(95)00143-h
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1147-1152
A convenient synthesis of new optically active 2-oxaisocephems with (N-alkylpyridinium-4′-thio)methyl groups at the 3-position and their biological activities are described. In particular, 10b and 10d having [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bbe58542b338271efbc2c347d76208f
https://doi.org/10.1016/s0960-894x(01)80245-6
https://doi.org/10.1016/s0960-894x(01)80245-6
Autor:
Koichi Tsuji, Shinji Nishitani, Koichi Yasumura, Nobuhito Tada, Hiroshi Ishikawa, Jun-ichi Minamikawa, Hidetsugu Tsubouchi
Publikováno v:
Tetrahedron: Asymmetry. 5:441-452
Asymmetric annelation of the disilylated imine 3 generated in situ from D-threonine 2 with arid chlorides 4 and triethylamine followed by esterificadon provided cis-β-lactams 5 and 6 in excellent yields with high diastereoselectivity under mild cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f92292320b4c8baf1fc4cf89454c3e
https://doi.org/10.1016/s0957-4166(00)86216-3
https://doi.org/10.1016/s0957-4166(00)86216-3
Autor:
Hiroshi Ishikawa, Nobuhito Tada, Shinji Nishitani, Hidetsugu Tsubouchi, Koichi Yasumura, Koichi Tsuji, Jun-ichi Minamikawa
Publikováno v:
ChemInform. 25
Asymmetric annelation of the disilylated imine 3 generated in situ from D-threonine 2 with arid chlorides 4 and triethylamine followed by esterificadon provided cis-β-lactams 5 and 6 in excellent yields with high diastereoselectivity under mild cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483630a6a075313913cde1dd7a28b6a2
https://doi.org/10.1002/chin.199435283
https://doi.org/10.1002/chin.199435283
Publikováno v:
ChemInform. 25
A convenient synthesis of new optically active 2-oxaisocephems with (N-alkylpyridinium-4′-thio)methyl groups at the 3-position and their biological activities are described. In particular, 10b and 10d having [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d405da0a2991adebee553133a80b71
https://doi.org/10.1002/chin.199444224
https://doi.org/10.1002/chin.199444224
Publikováno v:
ChemInform. 26
A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a 2-aminothiazol-4-yl moiety at the 7-position was synthesized via benzyl 3-acetyloxymethyl-7-azido-8- oxo-1-aza-4-oxabicyclo[4.2.0]oct-2-ene-2-carboxylate (2), de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb67a6ec1f72897e8175463d100a583f
https://doi.org/10.1002/chin.199523240
https://doi.org/10.1002/chin.199523240
Publikováno v:
Bioorganicmedicinal chemistry. 4(12)
A series of cephalosporins, 2-isocephems, and 2-oxaisocephems with C-3′ catechol-containing (pyridinium-4-thio)methyl groups and 2-isocephems with C-7 catechol related aromatics have been prepared and evaluated for antimicrobial activity. It turns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6152f3c1547be34c085305c191bed8d4
https://pubmed.ncbi.nlm.nih.gov/9022977
https://pubmed.ncbi.nlm.nih.gov/9022977
Autor:
Makoto Matsumoto, Takuya Shitsuta, Koichi Yasumura, Koichi Tsuji, Hidetsugu Tsubouchi, Hiroshi Ishikawa
Publikováno v:
Journal of medicinal chemistry. 38(12)
The preparation and biological evaluation of a series of 7-[2-(2-aminothiazol-4-yl)-2-(Z)-[(cyclopentyloxy)imino]acetamido] optically active 2-oxaisocephems, substituted at the 3-position with [(N-alkylpyridinium-4'-yl)thio]methyl groups, are describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7cdfc18c95726ef7e0c7d6177deb08
https://pubmed.ncbi.nlm.nih.gov/7783146
https://pubmed.ncbi.nlm.nih.gov/7783146