Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Koichi Yabe"'
Autor:
Koichi Yabe, Kazuhiko Mori, Noriko Sasaki, Kazuyoshi Kumagai, Kayoko Ishikawa, Kiyonori Kai, Takanori Maejima, Keiko Okado, Kyohei Yasuno
Publikováno v:
Journal of Toxicologic Pathology
A 40-week-old male spontaneous diabetic Torii rat, an animal model of type 2 diabetes mellitus, was found to have marked urinary calculi with hematuria in the urinary bladder on necropsy. Histological findings in the urinary bladder included a papill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad40e116032b1f5f932f4ac3918812d
https://doi.org/10.1293/tox.2019-0057
https://doi.org/10.1293/tox.2019-0057
Publikováno v:
Toxicologic Pathology. 47:35-43
We characterized pancreatic islet lesions induced by several quinolones using functional and morphological examinations of the pancreatic islets in male rats orally administered gatifloxacin, lomefloxacin, or levofloxacin at 300 mg/kg for 14 consecut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e18874355e681cf238ea30fdac8be7b
https://doi.org/10.1177/0192623318809062
https://doi.org/10.1177/0192623318809062
Autor:
Kazuhiko Mori, Takuma Iguchi, Keiko Okado, Koichi Yabe, Tatsuya Kawaguchi, Kiyonori Kai, Toshihiko Makino, Koichi Nakamura, Ayako Sayama
Publikováno v:
Toxicologic Pathology. 46:193-201
Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53d3295edcb128714ae6796ec5dc8e6
https://doi.org/10.1177/0192623317749469
https://doi.org/10.1177/0192623317749469
Autor:
Yosuke Ando, Koichi Yabe, Chiharu Kuwata, Kazuhiko Mori, Hiroshi Iida, Kazumi Ito, Takuya Matsuyama
Publikováno v:
Drug and Chemical Toxicology. 41:105-112
To clarify the molecular mechanism of ethylene glycol monomethyl ether (EGME)-induced testicular toxicity, the potential for EGME-related changes in transcript levels of genes including spermatocyte-specific genes was evaluated in the testis of rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6ed335b13b70d0c56c5021dc15803
https://doi.org/10.1080/01480545.2017.1320406
https://doi.org/10.1080/01480545.2017.1320406
Autor:
Susan A. Elmore, Brittany E Scott, Beth Mahler, John C. Seely, Sanam L Kavari, Koichi Yabe, Mark J. Hoenerhoff
Publikováno v:
Toxicol Pathol
Congenital abnormalities of the urinary tract are some of the most common human developmental abnormalities. Several genetically engineered mouse models have been developed to mimic these abnormalities and aim to better understand the molecular mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d9bbc8701432ddc55224ce47585146
https://europepmc.org/articles/PMC6814567/
https://europepmc.org/articles/PMC6814567/
Autor:
Tetsuji Noguchi, Yuki Domon, Koichi Yabe, Teppei Fujimoto, Rieko Takano, Yumi Kawase, Kazufumi Kubota, Umezaki Yuma, Miki Yokoyama, Kousei Shimada, Kenjiro Ueda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 36:127790
We identified (5R)-6-methyl-5-phenyl-1,3,4,5,6,7-hexahydro-2,5-methano-2,6-benzodiazonine (DS21980956: 4-(R)) as a novel [5.2.1]bicyclic basic compound. The scaffold was inspired by fentanyl or pethidine, which possess potent analgesic activities. DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134edc323b8d63075394ef43fac0a4d1
https://doi.org/10.1016/j.bmcl.2021.127790
https://doi.org/10.1016/j.bmcl.2021.127790
Publikováno v:
Airway pharmacology and treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a315eeccf62caba96e04c962c7261903
https://doi.org/10.1183/13993003.congress-2018.pa1052
https://doi.org/10.1183/13993003.congress-2018.pa1052
Autor:
Yoshitake Furuta, Makiko Yamada, Nobuhisa Masuda, Minoru Uchiyama, Koichi Yabe, Shin-ichi Inoue, Tsuneo Deguchi
Publikováno v:
Open Forum Infectious Diseases
Background Clostridium difficile infection (CDI) is the most common cause of diarrhea in hospitals. The only available intravenous (IV) therapy for CDI is metronidazole, which showed only a 52.4% cure rate in a prospective observational study. DS1196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b58c612af63454b478bf7df3b8456d
http://europepmc.org/articles/PMC5631360
http://europepmc.org/articles/PMC5631360
Estimation of glomerular filtration rate in dogs by a single-blood sample method involving iodixanol
Autor:
Ryosuke Iwama, Kiyoshi Takasuna, Koichi Yabe, Kazuhisa Furuhama, Yuji Uzuka, Masaaki Katayama, Y. Sasaki, Shunsuke Shimamura, Hiroshi Satoh
Publikováno v:
American journal of veterinary research. 76(9)
OBJECTIVE To establish a simplified single-blood-sample method (SBSM) involving iodixanol to estimate glomerular filtration rate (GFR) in dogs and compare data provided by that procedure with data provided by a conventional multiple-blood-sample meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcb310634ddf1bbd9bf6dc03c924405
https://pubmed.ncbi.nlm.nih.gov/26309112
https://pubmed.ncbi.nlm.nih.gov/26309112
Autor:
Sanae Takada, Yoshikazu Ishii, Yoshimi Tsuchiya, Kazuo T. Suzuki, Koichi Yabe, Toshimasa Jindo, Kazuhisa Furuhama
Publikováno v:
Toxicologic Pathology. 33:561-569
To ascertain the early pathophysiological features in canine renal papillary necrosis (RPN) caused by the neurotransmission enhancer nefiracetam, male beagle dogs were orally administered nefiracetam at 300 mg/kg/day for 4 to 7 weeks in comparison wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd37e0127be9426ba7f38d1dc328743
https://doi.org/10.1080/01926230500222593
https://doi.org/10.1080/01926230500222593